Correlation with Clinical Examination, Mammography, Cytology and Histology

Wållberg, Helena; Alveryd, A; Nasiell, K; Sundelin, P.; Bergvall, U.; Troell, S.

doi:10.1177/028418518502600203

Cited by 13 publications

(7 citation statements)

References 17 publications

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“…͑The literature is often vague in distinguishing transillumination/lightscanning from diaphan-ography. Typically, transillumination refers to white-light illumination, whereas diaphanography refers to red and NIR illumination.͒ Some studies, most notably those of Bartrum and Crow, 3 Wallberg et al, 4 and Budred et al, 5 have shown very favorable results comparing optical and radiological devices as screening tools. Other studies, most notably by Drexler, Davis, and Schofield, 6 Monsees, Destouet, and Gersell, 7 and Alveryd et al 8 have shown quite the opposite.…”

Section: History Of Early Breast Opticsmentioning

confidence: 99%

“…Knowledge of the absorption spectrum provides the information needed to solve a weighted least-squares problem to recover the concentrations of the four principal NIR absorbers in tissues: Hb-R, 4 . Since it is difficult to quantify lipids in terms of a concentration, the molar extinction coefficients were used as cm 2 Kg…”

Section: Calculation Tissue Physiology: Absorptionmentioning

confidence: 99%

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Spectroscopy enhances the information content of optical mammography

et al. 2002

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Abstract. Near-infrared (NIR) diffuse optical spectroscopy and imaging may enhance existing technologies for breast cancer screening, diagnosis, and treatment. NIR techniques are based on quantitative measurements of functional contrast between healthy and diseased tissue. In this study we measured the spectral dependence of tissue absorption ( a ) and reduced scattering ( s Ј) in the breasts of 30 healthy women and one woman with a fibroadenoma using a sevenwavelength frequency-domain photon migration probe. Subjects included pre-and postmenopausal women between the ages of 18 and 64. Multi-spectral measurements were used along with a fourcomponent fit to determine the concentrations of de-oxy and oxyhemoglobin, water and lipids in breast. The scattering spectral shape was also quantified. Our measurements demonstrate that the measured concentrations of NIR analytes correlate well with known breast physiology. Although the tissue scattering at a single wavelength was found to have little value as a functional parameter, the dependence of the scattering on wavelength provided key insights into breast composition and physiology. Lipids and scattering spectra in the breast were found to increase and decrease, respectively, with increasing body mass index. Simple calculations are also provided to demonstrate potential penalties from ignoring the contributions of water and lipids in breast measurements. Finally, water is shown to be a possible indicator for detecting a fibroadenoma, whereas the hemoglobin saturation was found to be a poor indicator. Multi-spectral measurements, compared to measurements restricted to one or two wavelengths, provide additional information that may be useful in managing breast disease.

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Section: History Of Early Breast Opticsmentioning

confidence: 99%

Section: Calculation Tissue Physiology: Absorptionmentioning

confidence: 99%

Spectroscopy enhances the information content of optical mammography

et al. 2002

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“…Optical methods applied to breast imaging in the 1980s consisted of trans-illumination and diaphanography, which used continuous-wave visible and NIR light, respectively, to visualize lesions [3]. These qualitative approaches did not account for the strongly scattering nature of NIR light propagation in tissue that led to high false negative and false positive rates and contradictory findings [4][5][6][7][8][9]. Advances in the understanding of light transport through turbid media during the 1990s led to the development of technologies based on DOS and diffuse optical imaging (DOI).…”

Section: Basic Principles Of Near-infrared Diffuse Optical Spectroscopymentioning

confidence: 99%

The Role of Diffuse Optical Spectroscopy in the Clinical Management of Breast Cancer

et al. 2004

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Diffuse optical spectroscopy (DOS) of breast tissue provides quantitative, functional information based on optical absorption and scattering properties that cannot be obtained with other radiographic methods. DOS-measured absorption spectra are used to determine the tissue concentrations of deoxyhemoglobin (Hb-R), oxyhemoglobin (Hb-O2), lipid, and water (H2O), as well as to provide an index of tissue hemoglobin oxygen saturation (StO2). Tissue-scattering spectra provide insight into epithelial, collagen, and lipid contributions to breast density. Clinical studies of women with malignant tumors show that DOS is sensitive to processes such as increased tissue vascularization, hypoxia, and edema. In studies of healthy women, DOS detects variations in breast physiology associated with menopausal status, menstrual cycle changes, and hormone replacement. Current research involves using DOS to monitor tumor response to therapy and the co-registration of DOS with magnetic resonance imaging. By correlating DOS-derived parameters with lesion pathology and specific molecular markers, we anticipate that composite “tissue optical indices” can be developed that non-invasively characterize both tumor and normal breast-tissue function.

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“…One of the reasons for this could be that fibroadenomas might have increased concentrations of erythrocytes even if the average concentration in carcinoma is reported to be higher (15). Also, inflammatory breast diseases, hema tomas, necroses, and cysts with bloody contents m a y mark edly reduce the transmittance of light, thus mimicking a malignant lesion (16).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Accuracy of Lightscanning and Mammography in Women with Dense Breasts

Jarlman¹,

Andersson²,

Balldin³

et al. 1992

Acta Radiol

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The diagnostic accuracy of lightscanning and mammography in 610 breasts with mammographically dense parenchymal patterns was investigated. Lightscanning identified 31 out of 36 cancers and mammography 32. Lightscanning and mammography were in agreement in 28 cases of cancer. One noninvasive lobular carcinoma was not identified by either modality. Four cancers were not cor rectly identified with lightscanning alone and 3 cancers with mam mography alone. Of the 574 breasts without cancer, lightscanning falsely denoted 101 (18%) as possibly being cancerous (false-posi tives). The corresponding figure for mammography was 25 (4%). Thus, lightscanning, as performed in this study, has the same sensi tivity as mammography in detecting cancer in mammographically dense breasts. However, its usefulness is limited by a low predictive value of a positive test (high rate of false-positives).

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Correlation with Clinical Examination, Mammography, Cytology and Histology

Cited by 13 publications

References 17 publications

Spectroscopy enhances the information content of optical mammography

Spectroscopy enhances the information content of optical mammography

The Role of Diffuse Optical Spectroscopy in the Clinical Management of Breast Cancer

Diagnostic Accuracy of Lightscanning and Mammography in Women with Dense Breasts

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