Correlations between Apparent Diffusion Coefficient Values and Prognostic Factors of Breast Cancer

Abstract

Purpose: We investigated possible correlations between apparent diŠusion coe‹cient (ADC) values and prognostic factors of breast cancer.Methods: We retrospectively evaluated 81 patients who underwent magnetic resonance (MR) imaging of the breast and were diagnosed pathologically with invasive ductal carcinoma (IDC) not otherwise speciˆed with invasive foci one cm or larger. We excluded ductal carcinoma in situ and IDC with invasive foci smaller than one cm because small lesions decrease the reliability of signal intensity of diŠusion-weighted imaging (DWI). We also excluded special type cancers. We used t-test to compare the mean ADC values of cancers of Stage pT1 (Ã2 cm) versus pT2 or 3 (À2 cm), cancers with versus without vascular invasion, axillary lymph node (N)-positive versus N-negative cancers, estrogen receptor (ER)-positive versus ER-negative cancers, and progesterone receptor (PgR)-positive versus PgRnegative cancers. We analyzed correlations between the ADC value with nuclear grade (NG) and human epidermal growth factor receptor 2 (HER2) score by rank test using Spearman's correlation coe‹cient.Results: The mean ADC value was signiˆcantly higher for N-positive (n＝28; 0.97±0.20 ×10 -3 mm 2 /s) than N-negative cancers (n＝53; 0.87±0.17×10 Conclusion: ADC values were higher for N-positive and ER-negative breast cancers than N-negative and ER-positive cancers.

Diagnostic Value of Diffusion-weighted Imaging and Apparent Diffusion Coefficient Values in the Differentiation of Breast Lesions, Histpathologic Subgroups and Correlatıon with Prognostıc Factors using 3.0 Tesla MR

“…Choi et al (30) did not report a correlation between the Her2 and ADC values in their study with 335 patients with invasive ductal carcinoma. Similarly, Kamitani et al (36) did not report a correlation between the Her2 and ADC values in their study with 81 patients with invasive breast cancer. Although we found no statistical significance in terms of ER and PR values and Her2 values compared with the literature, the mean ADC values were much lower in patients with negative ER, PR and Her2 than in the patients with positive ER, PR and Her2.…”

“…The results of the studies reported in the literature are inconsistent. The mean ADC values with very small differences were significant in some studies but not significant in others (31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41). Therefore, we believe large series with the participation of more patients are needed in this regard.…”

“…Various studies have investigated the relationship between tumor prognostic factors and DWI (30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41). Some studies concluded that there was a relationship between tumor grade and ADC values.…”

Comparison of diffusion-weighted imaging findings in brain metastases of different origin

“…Previously, it has been reported that positive breast cancer had significantly higher ADC values in comparison to Her2 negative carcinomas [16,17]. However, Kamitani et al showed no correlation of ADC and Her2 status [18].…”

Diagnostic Significance of Apparent Diffusion Coefficient Values with Diffusion Weighted MRI in Breast Cancer: a Meta-Analysis

“…Additionally, as for the step of screening, a flow chart of the study selection process was displayed in Figure 1. Initially, a total of 603 papers were selected from the 9 databases through screening the title and key words (Nakajo et al, 2010;Razek et al, 2010;Jeh et al, 2011;Nakai et al, 2011;Choi et al, 2012;Fornasa et al, 2012;Luo et al, 2012;Kamitani et al, 2013;Luo et al, 2013). Followed by excluding the duplicates (n=2), letters, reviews or meta-analysis (n=128), non-human studies (n=137), and the studies not related to research topics (n=145), the left studies (n=191) were reviewed and additional 179 studies were excluded in that they were not case-control or cohort study (n=48), not relevant to diffusion MRI (n=62), or not relevant to BC (n=69).…”