Correlations between C-reactive protein, interleukin-6, tumor necrosis factor-α and body mass index during senile osteoporosis

Maugeri, D.; Russo, Marco; Franze, Carmela; Motta, Vinı́cius; Motta, Massimo; Destro, G; Speciale, Salvatore; Sant’Angelo, Antonino; Panebianco, P.; Malaguarnera, Mariano

doi:10.1016/s0167-4943(98)00110-1

Cited by 25 publications

(16 citation statements)

References 4 publications

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“…Since IL-6 circulating levels are correlated with functional status, plasma levels of this cytokine have been proposed as a good biomarker of healthy ageing, because of the importance of IL-6 in both non-specific and specific responses (Pawelec et al 2002). However, the increase in circulating inflammatory molecules that we found (both cytokines and chemokines), is far from the levels evident during acute inflammation, thus indicating that ageing is associated with a chronic low-grade inflammatory response, which can be involved not only in autoimmune response (Brod 2000) but also in atherosclerosis and Alzheimer disease, for example, or in osteoporosis where increased levels of IL-6, TNF-a and C reactive protein has been described (Maugeri et al 1998).…”

Section: Discussioncontrasting

confidence: 64%

Simultaneous evaluation of circulating chemokine and cytokine profiles in elderly subjects by multiplex technology: relationship with zinc status

Mariani

Cattini²,

Neri³

et al. 2006

Biogerontology

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Cellular components of both adaptive and innate immune systems produce different chemokines and cytokines, involved in different signalling pathways among cells, and modulate effector function during immune response, playing a key role in the regulation of the type and extent of the immune response in the elderly. We evaluated the circulating concentration of selected chemokines: MCP-1, MIP-1alpha, IL-8, RANTES together with IL-6 and TNF-alpha in plasma obtained from a group of healthy old subjects, in order to highlight possible differences in the synthesis of these factors, assuming that both the cytokine and the chemokine networks are remodelled with ageing. The simultaneous evaluation was performed by a multiplex analysis system. In addition, since micronutrient deficiency may underlie an inflammatory response, the association between chemokine levels and a nutritional element such as zinc was also evaluated, since the immune system is the first system to be affected by changing zinc levels, due to its high cell turnover. A progressive age-related increase of plasma concentrations of all soluble factors was observed. The increment was particularly evident for IL-6, IL-8, MCP-1 and TNF-alpha in the over 85-year-old group in concomitance with increasing percentages of subjects with low circulating levels of zinc. In conclusion, the remodelling of chemokine profiles, skewed to Th2 response by both advanced ages and circulating levels of zinc, might reflect different states of activation and/or responsiveness of the human immune cell/mediator network, thus influencing the ability to develop rapid innate and long-lasting adaptive immune responses with advancing age.

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Section: Discussioncontrasting

confidence: 64%

Simultaneous evaluation of circulating chemokine and cytokine profiles in elderly subjects by multiplex technology: relationship with zinc status

Mariani

Cattini²,

Neri³

et al. 2006

Biogerontology

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“…In the pathogenesis of postmenopausal osteoporosis, estrogen deficiency results in a significant increase of inflammatory factors, such as TNF-a, IL-1b, and IL-6 [10,11]. In this experiment, accompanied with a decrease in the serum estrogen level (Ovx-1), an increase in the serum TNF-a concentration was observed, which was also demonstrated by other researchers [27,28]. Furthermore, lots of studies have showed that TNF-a contributed to inflammatory pain and pathological pain [15,29].…”

Section: Discussionsupporting

confidence: 84%

Blocking TNF-α with infliximab alleviates ovariectomy induced mechanical and thermal hyperalgesia in rats

Chen

Xie

et al. 2011

Neurol Sci

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Studies have proved an increased expression of tumor necrosis factor alpha (TNF-α) in estrogen deficiency animals, and TNF-α also plays a role in inflammation and neuropathic pain. This study aimed to explore the relationship between TNF-α and ovariectomy induced hyperalgesia. 36 female Sparague-Dawley were included, estrogen depletion models were established by ovariectomy. Then infliximab (a TNF-α blocker) was administrated to the ovariectomized rats for 8 weeks. Pain behavioral tests were performed once a week. The bone mineral density (BMD), serum estradiol and TNF-α level were determined at the 8th week after ovariectomy. The expression of TNF-α in lumbar 5 dorsal root ganglions (L5 DRGs) was examined by immunofluorescence method. Significant hyperalgesia to mechanical and thermal stimuli in groups Ovx-1 and Ovx-2 was observed 1 week after the operation. After treated with infliximab, the pain threshold of Ovx-2 was partially restored, although still lower than the Sham group. The serum TNF-α level of Ovx-1 was significantly higher than Sham and Ovx-2. TNF-α immunofluorescence indicated a significant increase in the expression of TNF-α at L5 DRGs in group Ovx-1 when compared with groups Sham and Ovx-2. The BMD of group Ovx-2 was significantly higher than group Ovx-1 and lower than group Sham. In conclusion, TNF-α plays an important role in estrogen deficiency induced mechanical and thermal hyperalgesia, and DRG may be one site on which TNF-α acts to cause hyperalgesia. Blocking the effect of TNF-α could partially alleviate the estrogen deficiency induced hyperalgesia in rats. Thus, TNF-α may contribute to chronic pain in postmenopausal women.

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“…The positive association between CRP and increased mortality in the elderly may be directly associated with the physiological immune response associated with the ageing process [29] or be mediated by a broad range of inflammatory and thrombotic conditions, such as atherosclerosis [30] and cardiovascular diseases [31,32]. As well, augmented hs-CRP levels are associated with an increased risk of decreased muscle function [33], disability and functional decline [34], osteoporotic and non-traumatic fractures [35,36], visceral adiposity [37], and hospitalization [38]. …”

Section: Discussionmentioning

confidence: 99%

C-Reactive Protein and B-Type Natriuretic Peptide Yield Either a Non-Significant or a Modest Incremental Value to Traditional Risk Factors in Predicting Long-Term Overall Mortality in Older Adults

Boersma

Diniz

et al. 2013

PLoS ONE

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BackgroundNew biomarkers may aid in preventive and end-of-life decisions in older adults if they enhance the prognostic ability of traditional risk factors. We investigated whether C-reactive protein (CRP) and/or B-type natriuretic peptide (BNP) improve the ability to predict overall mortality among the elderly of the Bambuí, Brazil Study of Aging when added to traditional risk factors.MethodsFrom 1997 to 2007, 1,470 community-dwelling individuals (≥60 years) were followed-up. Death was ascertained by continuous verification of death certificates. We calculated hazard ratios per 1 standard deviation change (HR) of death for traditional risk factors only (old model), and traditional risk factors plus CRP and/or BNP (new models) and assessed calibration of the models. Subsequently, we compared c-statistic of each of the new models to the old one, and calculated integrated discriminative improvement (IDI) and net reclassification improvement (NRI).Results544 (37.0%) participants died in a mean follow-up time of 9.0 years. CRP (HR 1.28, 95% CI 1.17-1.40), BNP (HR 1.31 95% CI 1.19-1.45), and CRP plus BNP (HR 1.26, 95% CI 1.15-1.38, and HR 1.29, 95% CI 1.16-1.42, respectively) were independent determinants of mortality. All models were well-calibrated. Discrimination was similar among the old (c-statistic 0.78 [0.78-0.81]) and new models (p=0.43 for CRP; p=0.57 for BNP; and p=0.31 for CRP plus BNP). Compared to the old model, CRP, BNP, and CRP plus BNP models led to an IDI of 0.009 (p<0.001), -0.005 (p<0.001) and -0.003 (p=0.84), and a NRI of 0.04 (p=0.24), 0.07 (p=0.08) and 0.06 (p=0.10), respectively.ConclusionsDespite being independent predictors of long-term risk of death, compared to traditional risk factors CRP and/or BNP led to either a modest or non-significant improvement in the ability of predicting all-cause mortality in older adults.

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Correlations between C-reactive protein, interleukin-6, tumor necrosis factor-α and body mass index during senile osteoporosis

Cited by 25 publications

References 4 publications

Simultaneous evaluation of circulating chemokine and cytokine profiles in elderly subjects by multiplex technology: relationship with zinc status

Simultaneous evaluation of circulating chemokine and cytokine profiles in elderly subjects by multiplex technology: relationship with zinc status

Blocking TNF-α with infliximab alleviates ovariectomy induced mechanical and thermal hyperalgesia in rats

C-Reactive Protein and B-Type Natriuretic Peptide Yield Either a Non-Significant or a Modest Incremental Value to Traditional Risk Factors in Predicting Long-Term Overall Mortality in Older Adults

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