Correlations between corneal hysteresis, intraocular pressure, and corneal central pachymetry

Touboul, David; Roberts, Cynthia R.; Kérautret, J.; Garra, C.; Maurice-Tison, S.; Saubusse, Élodie; Colin, Joseph

doi:10.1016/j.jcrs.2007.11.051

Cited by 255 publications

(220 citation statements)

References 13 publications

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“…Although CH is moderately correlated with CCT, CH and corneal compensated IOP measurements are less affected by corneal oedema than are GAT measurements. 33,37,38 Furthermore, IOPcc may be one of the most appropriate measures of IOP before and after keratorefractive procedures and in eyes with keratoconus or corneal oedema. 14,[33][34][35][36]39 In light of these and other findings, the ORA is an appealing tool for the measurement of IOP and ocular biomechanical characteristics.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of agreement between intraocular pressure measurements using Goldmann applanation tonometry and Goldmann correlated intraocular pressure by Reichert's ocular response analyser

Ehrlich

Haseltine

Shimmyo

et al. 2010

Eye

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Purpose To compare agreement of intraocular pressure (IOP) measurements using Goldmann applanation tonometry (GAT) and Goldmann correlated intraocular pressure generated (IOPg) by the Reichert ocular response analyser (ORA). Methods Consecutive patients presenting for glaucoma evaluation underwent ORA assessment followed by examination including GAT. For each ORA assessment, measurements were taken until a waveform score (WS) of 6.5 was obtained or until five measurements were obtained per eye. The relationship between GAT and IOPg and the influence of the WS upon this relationship was evaluated. A Bland-Altman plot and linear regression were used to determine agreement between GAT and IOPg. Results A total of 518 eyes of 260 patients were included in the final analysis. Increasing WS was found to predict a smaller difference between GAT and IOPg (b ¼ À0.2, Pp0.001). Selecting the highest WS among ORA assessments of each eye, WS continued to predict concordance between GAT and IOPg (b ¼ À0.2, P ¼ 0.006). The mean IOP difference between methods was 0.1 mm Hg (±0.3), which was found to be statistically insignificant (P ¼ 0.391). This relationship between GAT and IOPg was successfully validated using a second distinct data set of 100 eyes. GAT and IOPg measurements varied by 2 mm Hg or less in 53.9% of eyes and 5 mm Hg or less in 92.3% of eyes. Conclusion In clinical practice IOPg is strongly related to GAT. Although higher WS is indicative of greater IOPg/GAT concordance, its influence is minimal. This study does not support the use of a specific WS cutoff to determine quality of an IOPg measurement.

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Section: Discussionmentioning

confidence: 99%

Evaluation of agreement between intraocular pressure measurements using Goldmann applanation tonometry and Goldmann correlated intraocular pressure by Reichert's ocular response analyser

Ehrlich

Haseltine

Shimmyo

et al. 2010

Eye

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“…The mean (SD) CCT was similar between dystrophy (542 [31] μm) and control groups (537 [11] μm) (P=0.65). The mean (SD) corneal hysteresis in the dystrophy and control groups were 11.2 (1.5) mmHg and 9.7 (1.2) mmHg, respectively (P=0.04).…”

Section: Resultsmentioning

confidence: 93%

“…More recently, corneal biomechanical properties have been evaluated using the Ocular Response Analyzer (ORA), which measures the corneal hysteresis (CH) -an estimation of the viscous damping properties of the cornea (10,11) . The ORA and the dynamic contour tonometry (DCT) can provide cornealcompensated IOP measurements.…”

Section: Introductionmentioning

confidence: 99%

Intraocular pressure, corneal thickness, and corneal hysteresis in Steinert's myotonic dystrophy

Filho

Prata

Sousa

et al. 2011

Arq. Bras. Oftalmol.

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Purpose: Low intraocular pressure (IOP) measured by Goldmann applanation tonometry (GAT) is one of the ocular manifestations of Steinert's myotonic dystrophy. The goal of this study was to evaluate the corneal-compensated IOP as well as corneal properties (central corneal thickness and corneal hysteresis) in patients with myotonic dystrophy. Methods: A total of 12 eyes of 6 patients with Steinert's myotonic dystrophy (dystrophy group) and 12 eyes of 6 age-, race-, and gender-matched healthy volunteers (control group) were included in the study. GAT, Dynamic Contour Tonometry (DCT-Pascal) and Ocular Response Analyzer (ORA) were used to assess the IOP. Central corneal thickness was obtained by ultrasound pachymetry, and corneal hysteresis was analyzed using the ORA device. In light of the multiplicity of tests performed, the significance level was set at 0.01 rather than 0.05. Results:The mean (standard deviation [SD]) GAT, DCT, and corneal-compensated ORA IOP in the dystrophy group were 5.4 (1.4) mmHg, 9.7 (1.5) mmHg, and 10.1 (2.6) mmHg, respectively. The mean (SD) GAT, DCT, and corneal-compensated ORA IOP in the control group was 12.6 (2.9) mmHg, 15.5 (2.7) mmHg, and 15.8 (3.4) mmHg, respectively. There were significant differences in IOP values between dystrophy and control groups obtained by GAT (mean, -7.2 mmHg; 99% confidence interval [CI], -10.5 to -3.9 mmHg; P<0.001), DCT (mean, -5.9 mmHg; 99% CI, -8.9 to -2.8 mmHg; P<0.001), and corneal-compensated ORA measurements (mean, -5.7 mmHg; 99% CI, -10.4 to -1.0 mmHg; P=0.003). The mean (SD) central corneal thickness was similar in the dystrophy (542 [31] μm) and control (537 [11] μm) groups (P=0.65). The mean (SD) corneal hysteresis in the dystrophy and control groups were 11.2 (1.5) mmHg and 9.7 (1.2) mmHg, respectively (P=0.04). Conclusions: Patients with Steinert's myotonic dystrophy showed lower Goldmann and corneal-compensated IOP in comparison with healthy individuals. Since central corneal thickness and corneal hysteresis did not differ significantly between groups, the lower IOP readings documented in this dystrophy seem not to be related to changes in corneal properties. 12,6 (2,9) mmHg, 15,5 (2,7) mmHg e 15,8 (3,4) mmHg, respectivamente. Houve diferença significativa nos valores da pressão intraocular entre os grupos distrofia e controle obtidas pela TAG (média,2 mmHg; intervalo de confiança (IC) de 99%,9 mmHg; P<0,001), TCD (média,9 mmHg; IC de 99%,8 mmHg; P<0,001) e ORA compensada para córnea (média,7 mmHg; IC de 99%,0 mmHg; P=0,003 Keywords

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“…When other covariates were considered, this correlation lost its significance. Comparing CH values in POAG patients with and without acquired pits of the ONH, Bochmann et al 36 42 was not assessed in that study. On the other hand, Wells et al 13 correlated higher CH values (but not CCT) with greater changes in ONH topography after IOP increase.…”

Section: Discussionmentioning

confidence: 94%

“…40,41 CH is correlated with CCT, and seems not to be associated with refractive error or axial length. 42,43 CH as measured by the ORA is described in greater detail elsewhere. 40,41,44 For this study, four measurements were obtained for each eye and the average was considered as the final value for analysis.…”

Section: Methodsmentioning

confidence: 99%

Factors associated with topographic changes of the optic nerve head induced by acute intraocular pressure reduction in glaucoma patients

Prata

Lima

Moraes

et al. 2010

Eye

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Purpose To investigate factors associated with changes in optic nerve head (ONH) topography after acute intraocular pressure (IOP) reduction in patients with primary open-angle glaucoma (POAG). Methods Untreated POAG patients (IOP 421 mm Hg) were prospectively enrolled. Systemic and ocular information were collected, including central corneal thickness (CCT) and corneal hysteresis (CH). All patients underwent confocal scanning laser ophthalmoscopy and tonometry (Goldmann) before and 1 h after pharmacological IOP reduction. The mean of three measurements was considered for analysis. Changes in each ONH topographic parameter were assessed (one eye was randomly selected), and those that changed significantly were correlated with patient's systemic and ocular characteristics. Results A total of 42 patients were included (mean age, 66.7 ± 11.8 years). After a mean IOP reduction of 47.3±11.9%, significant changes were observed in cup area and volume, and in rim area and volume (Po0.01), but not in mean cup depth (P ¼ 0.80). Multiple regression analysis (controlling for baseline IOP and magnitude of IOP reduction) showed that CH (r 2 ¼ 0.17, Po0.01) and diabetes diagnosis (r 2 X0.21, Po0.01) were negatively correlated with the magnitude of changes in ONH parameters, whereas the cup-to-disc ratio was positively correlated (r 2 ¼ 0.30, Po0.01). Age, race, disc area, and CCT were not significant (PX0.12). Including all significant factors in a multivariable model, only the presence of diabetes remained significantly associated with all ONH parameters evaluated (Po0.01). Conclusions Different systemic and ocular factors, such as diabetes, CH, and the relative size of the cup, seem to be associated with the magnitude of changes in ONH topography after acute IOP reduction in POAG patients. These associations partially explain the ONH changes observed in these patients and suggest that other factors are possibly implicated in an individual susceptibility to IOP.

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Correlations between corneal hysteresis, intraocular pressure, and corneal central pachymetry

Abstract: Corneal hysteresis, a new corneal parameter, had a moderate dependence on IOP and CCT US. Weaker corneas could be screened with ORA parameters, and low CH could be considered a risk factor for underestimation of IOP. The CCT US should continue to be considered a useful parameter.

Cited by 255 publications

References 13 publications

Evaluation of agreement between intraocular pressure measurements using Goldmann applanation tonometry and Goldmann correlated intraocular pressure by Reichert's ocular response analyser

Evaluation of agreement between intraocular pressure measurements using Goldmann applanation tonometry and Goldmann correlated intraocular pressure by Reichert's ocular response analyser

Intraocular pressure, corneal thickness, and corneal hysteresis in Steinert's myotonic dystrophy

Factors associated with topographic changes of the optic nerve head induced by acute intraocular pressure reduction in glaucoma patients

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