Correlations between long-term quality of life and patient needs and concerns following head and neck cancer treatment and the impact of psychological distress. A multicentric cross-sectional study

Elaldi, Roxane; Roussel, L.; Gal, Jocelyn; Scheller, Boris; Chamorey, Emmanuel; Schiappa, Renaud; Lasne-Cardon, Audrey; Louis, Marie-Yolande; Culié, Dorian; Dassonville, O.; Poissonnet, G.; Saâda, Esma; Bénézery, Karen; Babin, E.; Bozec, A.

doi:10.1007/s00405-020-06326-8

Cited by 22 publications

(23 citation statements)

References 30 publications

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“…Median survey follow-up time was 34. 4 To assess for nonresponse bias, we compared baseline characteristics of the responders with the 104 nonresponders and found no significant differences in follow-up time (had the survey been completed by the end of the study), age, sex, ASA class, disease subsite, disease pathologic characteristics, overall stage, and type of flap (eTable in the Supplement).…”

Section: Patient Characteristicsmentioning

confidence: 99%

“…1 Owing to fear of disease recurrence, functional deficits, and aesthetic changes, up to 40% of these patients may develop depression at some point in their treatment course. [2][3][4] Ablative surgery is a necessary step in oncologic control but often disturbs nearby structures that are necessary for self-expression and social interaction. 5 Patients subsequently undergoing head and neck reconstruction emphasize altered facial appearance as a key contributor to impaired psychosocial functioning.…”

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confidence: 99%

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Patient-Reported Aesthetic and Psychosocial Outcomes After Microvascular Reconstruction for Head and Neck Cancer

Zebolsky

Patel

Heaton

et al. 2021

JAMA Otolaryngol Head Neck Surg

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IMPORTANCE Aesthetic outcomes are key determinants of psychosocial functioning among surgically treated patients with head and neck cancer (HNC); however, long-term aesthetic outcomes after microvascular free tissue transfer (MFTT) are not well described.OBJECTIVE To examine risk factors for impaired long-term aesthetic satisfaction and appearance-related psychosocial functioning after HNC ablation with MFTT. DESIGN, SETTING, AND PARTICIPANTSA cross-sectional, web-based survey was conducted at an academic tertiary care center.

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Section: Patient Characteristicsmentioning

confidence: 99%

mentioning

confidence: 99%

Patient-Reported Aesthetic and Psychosocial Outcomes After Microvascular Reconstruction for Head and Neck Cancer

Zebolsky

Patel

Heaton

et al. 2021

JAMA Otolaryngol Head Neck Surg

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“…Fear of cancer recurrence (FCR) is “ the fear, worry or concern that cancer will return or progress ” 1 . It is one of the most important concerns 2–4 and unmet needs for help 2,5,6 amongst patients with head and neck cancer (HNC). Across disease phases, 31% to 83% of HNC patients report mild to high levels of FCR 7–12 .…”

Section: Introductionmentioning

confidence: 99%

Prospective longitudinal study on fear of cancer recurrence in patients newly diagnosed with head and neck cancer: Course, trajectories, and associated factors

Deuning-Smit¹,

Custers²,

Miroševič

et al. 2022

Head & Neck

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Background This study assessed the course of fear of cancer recurrence (FCR) in patients newly diagnosed with head and neck cancer (HNC), identified FCR trajectories and factors associated with FCR trajectories. Methods Six hundred and seventeen HNC patients from the NET‐QUBIC cohort study completed the Cancer Worry Scale‐6 at diagnosis, 3 and 6 months post‐treatment. FCR trajectories were identified using Latent Class Growth Analysis. Associations were explored between FCR trajectories and baseline demographic and medical variables, coping and self‐efficacy. Results Overall, FCR decreased slightly between baseline and 3 months post‐treatment and remained stable up to 6 months. Two FCR trajectories were identified: “high stable” (n = 125) and “low declining” (n = 492). Patients with high stable FCR were younger, reported more negative adjustment, passive coping, and reassuring thoughts, and less avoidance. Conclusions The majority of HNC patients have low declining FCR after diagnosis, but one in five patients experience persistent high FCR up to 6 months post‐treatment.

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“…Gender was found to influence the QLQ-C30 SumSc at 1 year of follow-up. A suggested reason for this could be a difference in coping and interpretation of symptoms, which has also been described by Elaldi et al and Sehlen et al [ 20 , 21 ] When evaluating individual symptom scores of the C30 and BN20, several remarkable observations were made, as they showed contradictory behavior to the global QoL scores. Visual disorder scores showed a trend to improve over time, although this was not significant.…”

Section: Discussionmentioning

confidence: 87%

A Prospective Study on Health-Related Quality of Life and Patient-Reported Outcomes in Adult Brain Tumor Patients Treated with Pencil Beam Scanning Proton Therapy

Kroeze

Mackeprang

Angelis

et al. 2021

Cancers

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Proton therapy (PT) is delivered to complex brain tumors to obtain an optimal curative treatment with limited toxicity. Value-based oncological medicine is increasingly important, particularly when long-term survival is to be expected. This study aims to evaluate health-related quality of life (HRQOL) and patient reported outcomes (PROs) in patients treated with PT for brain tumors. Adult patients with brain tumors treated with PT filled out the EORTC-QLQ-C30 and BN20 questionnaires up to three years following PT. Toxicity was scored using the CTCAE v4.03. QoL and PRO were correlated to clinical factors. Three-year overall survival, distant brain control and local control rates were 98%, 97% and 84%, respectively. No ≥G3 acute toxicity was observed. Late PT-related ≥G3 severe toxicity occurred in seven patients (5.7%). Lower global QoL scores after PT were significantly correlated to low Karnofsky performance status (KPS) before PT (p = 0.001), surgical complications before PT (p = 0.04) and progressive disease (p = 0.017). A low QLQ-30 summary score at one year follow-up was correlated to sex (p = 0.015), low KPS before PT (p < 0.001), and central nervous system symptoms before PT (p = 0.018). Reported QLQ-BN20 neurological symptoms were correlated to lower KPS at baseline (p < 0.001) and surgical complications before PT (p = 0.03). PT-related toxicity only influenced reported symptoms directly following PT, but not QoL. Although global QoL temporarily decreased after treatment, it improved again from one year onwards. Global QoL and reported symptoms over time were not correlated with the proton therapy and were more related to preexisting symptoms and progressive disease. This study assists in improving patient support in patients with brain tumors receiving PT.

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Correlations between long-term quality of life and patient needs and concerns following head and neck cancer treatment and the impact of psychological distress. A multicentric cross-sectional study

Cited by 22 publications

References 30 publications

Patient-Reported Aesthetic and Psychosocial Outcomes After Microvascular Reconstruction for Head and Neck Cancer

Patient-Reported Aesthetic and Psychosocial Outcomes After Microvascular Reconstruction for Head and Neck Cancer

Prospective longitudinal study on fear of cancer recurrence in patients newly diagnosed with head and neck cancer: Course, trajectories, and associated factors

A Prospective Study on Health-Related Quality of Life and Patient-Reported Outcomes in Adult Brain Tumor Patients Treated with Pencil Beam Scanning Proton Therapy

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