Correlations between Physical and Drug Release Characteristics of Polyethylene Glycol Suppositories

Kellaway, I.W.; Marriott, Christopher

doi:10.1002/jps.2600640706

Cited by 18 publications

(4 citation statements)

References 10 publications

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“…The first type consists of simple placement of the suppository in a flask or beaker (Whitworth & LaRocca 1959;Pagay et al 1974). The second type utilizes an existing tablet dissolution apparatus with a wire-mesh basket for holding the sample (Kellaway & Marriott 1975;Parrott 1975). The third and fourth types employ a membrane; the third consists of a sample chamber separated from a reservoir by a membrane Correspondence: M. Asikoglu, Pharmaceutical Technology Department, Faculty of Pharmacy, Ege University, Izmir, Turkey.…”

mentioning

confidence: 99%

The Release of Isoconazole Nitrate from Different Suppository Bases: In-vitro Dissolution, Physicochemical and Microbiological Studies

Aşıkoğlu

Ertan

Cosar³

1995

Journal of Pharmacy and Pharmacology

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The influence of the suppository base on the in-vitro release of isoconazole nitrate was studied by dissolution, physicochemical diffusion and microbiological disk-diffusion methods. Vaginal suppository formulations containing 25 mg isoconazole nitrate for local treatment of vaginitis were prepared by a fusion method, using different hydrophilic and lypophilic suppository bases (PEG 6000, PEG 4000, PEG 1500, Witepsol H15, Novata BD and Cremao). In-vitro release rates were examined by dissolution, physicochemical diffusion and microbiological disk-diffusion methods. In the physicochemical investigations the pH indicators (pH 1-14) erythrosin B, thymol blue, bromocresol green, chlorophenol red, phenol red, and alkali blue were added to agar gels. The discs were placed onto the agar gels and 21 h later, the coloured zone diameters were measured. In the microbiological investigations, the discs were put on the inoculated plates with the suspension of Candida albicans (Institute Pasteur 628). The inoculated plates were incubated at 37 degrees C for 3 days, then the diameters of inhibition zones were measured. In the dissolution investigations release rates were in the order PEG 6000> PEG 4000 > PEG 1500 > > Witepsol H15 > Cremao > Novata BD. The diffusion distance of isoconazole nitrate in the physicochemical investigation was in the order polyethylene glycols > Witepsol H15 > Novata BD. In the microbiological studies release rates were found with polyethylene glycols > Witepsol H15 > Novata BD > Cremao. The findings in the in-vitro studies suggested that polyethylene glycols are suitable bases for vaginal suppositories.

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confidence: 99%

The Release of Isoconazole Nitrate from Different Suppository Bases: In-vitro Dissolution, Physicochemical and Microbiological Studies

Aşıkoğlu

Ertan

Cosar³

1995

Journal of Pharmacy and Pharmacology

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“…The formulations generally use both categories of Macrogols, for compensatory purposes, mixed in various proportions as required to obtain a inished product of satisfactory hardness and dissolution time (Raymond et al, 2006;Berkó, 2002;Kellaway and Marriott, 1975). Different PEG ratios of low and high molecular weight can be used to alter the time to disintegrate the hardness of the suppository (Raymond et al, 2006;Kellaway and Marriott, 1975;Chatterjee et al, 2014). Figure 4 shows the iso-résponses curves of the different combinations of Macrogol for both responses each taken alone.…”

Section: Determination Of the Optimal Formula By Maximizing The Multimentioning

confidence: 99%

“…Figure 4 shows the iso-résponses curves of the different combinations of Macrogol for both responses each taken alone. The PEG 6000, which has a higher molecular weight, will be tougher than the PEG 4000, but both can break and delay disintegration, whereas the addition of PEG 400 and 600 makes the suppositories hard, elastic and In view of drug incompatibilities, it is advantageous to minimize the proportions of low molecular weight PEGs because they have higher OH-values (Kellaway and Marriott, 1975;Chatterjee et al, 2014;Duangjit et al, 2014).…”

Section: Determination Of the Optimal Formula By Maximizing The Multimentioning

confidence: 99%

Application of design mixture and desirability function in the optimization of pharmaco-technical parameters of macrogols-based suppositories

Benomar

Yanisse

Charkaoui

et al. 2020

ijrps

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The objective of this work is to (i) study the effect of variations in the proportions of four Macrogols on the pharmaco-technical characteristics of suppositories, (ii) define the optimal formula for a suppository with immediate effect; maximum disintegration and a minimum of hardness as defined in the European Pharmacopoeia. The lattice design mixture has been proposed as an optimization technique, the formulation factors are presented by the proportions of PEG 400 (X1), PEG 600 (X2), PEG 4000 (X3) and PEG 6000 (X4) and the response variables are (i) the disintegration time (Y1) (ii) the hardness (Y2). The second-degree empirical model was postulated to model the variations of the two response variables using the least-squares method. The selected model explained about 67% and 84% of the variation for Y1 and Y2, respectively. All four factors had significant effects on the properties of the suppository. Interactions negatively affected both responses. The numerical desirability method gave the following optimal formula: PEG400 (28.71334 %); PEG600 (24.23773%), PEG4000 (35.00944%) and PEG6000 (12.03949%) for a disintegration of 25.839 (+/-2.3) min and hardness =2147.321 (+/- 50) g.

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“…Polyethylene glycol 1500 (PEG) is a water soluble suppository base which is widely used as excipients in a variety of pharmaceutical formulations, such as oral tablets and caplets, solutions and syrups, topical, rectal and vaginal preparations, ophthalmic, dental and parenteral systems (19,20).…”

Section: Introductionmentioning

confidence: 99%

Comparative bone uptake study of alendronate sodium from vaginal suppositories prepared with polyethylene glycol and massa estarinum bases

Özdemir¹,

Köseoğlu²,

Aşıkoğlu³

2013

mpj

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The unique properties like rich blood supply and the large surface area makes vagina an important area for systemic drug delivery (15). The advan-ABSTRACT: The aim of this study was to compare the bone uptake of alendronate sodium (ALD) from vaginal suppositories prepared with massa estarinum AB (ME) and polyethylene glycol 1500 (PEG) bases. For this purpose, ALD was radiolabeled with 99m Tecnetium Pertechnetate ( 99m Tc) by direct method. Radiochemical purity and stability of 99m Tc-ALD was performed with chromatographic studies. 99m Tc-ALD containing suppositories were prepared with ME and PEG bases. Physical properties of suppositories were evaluated. The physicochemical diffusion study was carried out to compare the release of ALD from different suppository bases. The bone uptake of 99m Tc-ALD was observed by gamma scintigraphy studies. 99m Tc-ALD containing suppositories were administrated to rabbits via vaginal route. The scintigraphic images were obtained with a gamma camera at different time intervals up to 240 minutes. According to our studies, radiochemical purity of 99m Tc-ALD was observed more than 95% up to 6 hours. At 240 minutes of physicochemical diffusion studies, released ALD has 0.620 ± 0.091 mm and 10.465 ± 0.651 mm diameter zone from ME and PEG base suppositories respectively. According to the gamma scintigraphy studies, although no bone uptake observed after ME suppositories application, rabbit's bones were clearly visible after PEG suppositories applied. The results of physicochemical diffusion and gamma scintigraphy studies were found compatible in each other.

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Correlations between Physical and Drug Release Characteristics of Polyethylene Glycol Suppositories

Cited by 18 publications

References 10 publications

The Release of Isoconazole Nitrate from Different Suppository Bases: In-vitro Dissolution, Physicochemical and Microbiological Studies

The Release of Isoconazole Nitrate from Different Suppository Bases: In-vitro Dissolution, Physicochemical and Microbiological Studies

Application of design mixture and desirability function in the optimization of pharmaco-technical parameters of macrogols-based suppositories

Comparative bone uptake study of alendronate sodium from vaginal suppositories prepared with polyethylene glycol and massa estarinum bases

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