Correlations between plasma strontium concentration, components of calcium and phosphate metabolism and renal function in type 2 diabetes mellitus

Berkhof, Yvette Sophie van den; Gant, Christina M.; Maatman, R.; Graaf, A. De; Navis, Gerjan; Bakker, Stephan J. L.; Laverman, Gozewijn D.

doi:10.1111/eci.12987

Cited by 6 publications

(8 citation statements)

References 24 publications

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“…That Sr is also excessively reabsorbed across the renal tubular epithelium is a sound hypothesis, albeit not documented. Subsequently, patients with HELIX syndrome may have a higher than normal serum Sr concentration, all the more so since serum Sr level increases when GFR decreases 82 . Thus, a higher serum Sr level may result in a higher deposition of Sr in bone and tooth.…”

Section: Discussionmentioning

confidence: 99%

“…It is much lower than normal glomerular filtration rate, indicating that Sr excreted in urine is only a tiny fraction of filtered Sr: therefore, most of Sr filtered at the glomerulus is reabsorbed along the renal tubule, as Ca and Mg are. 82,83 Patients with HELIX syndrome have very low urinary calcium and magnesium excretion in urine, despite normal serum Ca and high serum Mg levels, indicative of increased tubular Ca and Mg reabsorption. 32 That Sr is also excessively reabsorbed across the renal tubular epithelium is a sound hypothesis, albeit not documented.…”

Section: Discussionmentioning

confidence: 99%

“…Subsequently, patients with HELIX syndrome may have a higher than normal serum Sr concentration, all the more so since serum Sr level increases when GFR decreases. 82 Thus, a higher serum Sr level may result in a higher deposition of Sr in bone and tooth. Future studies are needed to investigate whether abnormal levels of Sr are also identified in bones of HELIX syndrome patients and, more broadly, how the kidney dysfunction associated with the HELIX syndrome impacts plasma and urine Sr concentrations.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Impact of claudin‐10 deficiency on amelogenesis: Lesson from a HELIX tooth

Obtel

Cabec

Nguyen

et al. 2022

Annals of the New York Academy of Sciences

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HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of claudin‐10 deficiency on amelogenesis: Lesson from a HELIX tooth

Obtel

Cabec

Nguyen

et al. 2022

Annals of the New York Academy of Sciences

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“…Fibroblast growth factor-23 (FGF-23) is a hormone that plays an important role in vitamin D and phosphate homeostasis [ 77 ]. In patients with T2DM and CKD, increased serum FGF-23 levels were associated with macroalbuminuria and creatinine levels [ 77 , 78 , 79 , 80 ]. In addition, serum FGF-23 levels predicted an increased risk for DKD progression [ 81 ].…”

Section: Fibroblast Growth Factor-23mentioning

confidence: 99%

Novel Cardiovascular Risk Factors in Patients with Diabetic Kidney Disease

Kourtidou

Stangou

Marinaki

et al. 2021

IJMS

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Patients with diabetic kidney disease (DKD) are at very high risk for cardiovascular events. Only part of this increased risk can be attributed to the presence of diabetes mellitus (DM) and to other DM-related comorbidities, including hypertension and obesity. The identification of novel risk factors that underpin the association between DKD and cardiovascular disease (CVD) is essential for risk stratification, for individualization of treatment and for identification of novel treatment targets.In the present review, we summarize the current knowledge regarding the role of emerging cardiovascular risk markers in patients with DKD. Among these biomarkers, fibroblast growth factor-23 and copeptin were studied more extensively and consistently predicted cardiovascular events in this population. Therefore, it might be useful to incorporate them in risk stratification strategies in patients with DKD to identify those who would possibly benefit from more aggressive management of cardiovascular risk factors.

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“…For example, researchers suggested that serum strontium was associated with an increased risk of renal insufficiency ( 13 , 14 ). Besides, serum strontium has been proven to be negatively related to the estimated glomerular filtration rate (eGFR) in the diabetic population ( 15 ). Another study showed that patients with high serum strontium were at an increased risk for acute kidney injury after cardiac surgery ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

The correlation of urinary strontium with the risk of chronic kidney disease among the general United States population

Zhang,

Hu,

et al. 2023

Front. Public Health

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BackgroundThis study sought to illustrate whether urinary strontium levels were related to developing chronic kidney disease (CKD) in the United States population.MethodsA total of 5,005 subjects were identified from the National Health and Nutrition Examination Survey 2011–2016. Survey-weighted logistic regression analysis, multivariate linear regression analysis, restricted cubic spline (RCS) plots curve and stratified analyses were undertaken to explicate the correlation between urinary strontium and CKD.ResultsWith the increase of urinary strontium, the incidence rate of CKD and urinary albumin to creatinine ratio (UACR) levels gradually decreased, and estimated glomerular filtration rate (eGFR) levels gradually increased. After controlling all confounders, only urinary strontium in the fourth quartile was correlated to a lower CKD prevalence (OR: 0.59; 95% CI, 0.44–0.79) compared to the lowest quartile. Multivariate linear regression analysis showed that urinary strontium was positively correlated with eGFR but negatively with UACR. RCS curve suggested a nonlinear relationship between urinary strontium and CKD (P for non-linearity <0.001). Stratified analyses indicated no significant difference in the correlation between urinary strontium and CKD among different subgroups.ConclusionUrinary strontium was strongly correlated with a low risk of CKD, and this association was non-linear among the US population.

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Correlations between plasma strontium concentration, components of calcium and phosphate metabolism and renal function in type 2 diabetes mellitus

Cited by 6 publications

References 24 publications

Impact of claudin‐10 deficiency on amelogenesis: Lesson from a HELIX tooth

Impact of claudin‐10 deficiency on amelogenesis: Lesson from a HELIX tooth

Novel Cardiovascular Risk Factors in Patients with Diabetic Kidney Disease

The correlation of urinary strontium with the risk of chronic kidney disease among the general United States population

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