Correlations between Risk Factors for Breast Cancer and Genetic Instability in Cancer Patients—A Clinical Perspective Study

Paz, Márcia Fernanda Correia Jardim; Alencar, Marcus Viní­cius Oliveira Barros de; Junior, Antonio Luiz Gomes; Machado, Keylla da Conceição; Islam, Muhammad Torequl; Ali, Eunüs S.; Shill, Manik Chandra; Ahmed, Mohammad Bashir; Uddin, Shaikh Jamal; Mata, Ana M.; Carvalho, Rezanio Martins; Machado, Kátia da Conceição; Sobral, André Luiz Pinho; Silva, Felipe Cavalcanti Carneiro da; Souza, João Marcelo de Castro e; Arcanjo, Daniel Dias Rufino; Ferreira, Paulo Michel Pinheiro; Mishra, Siddhartha; Silva, Juliana da; Melo‐Cavalcante, Ana Amélia de Carvalho

doi:10.3389/fgene.2017.00236

Cited by 13 publications

(10 citation statements)

References 68 publications

(76 reference statements)

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“…Abnormal activity of this process may lead to cancer susceptibility (Huang et al, ). Genomic instability caused by DNA lesions may contribute to the inefficiency of DNA repair genes (Paz et al, ). Therefore, studying genetic variants such as SNPs and their causes of leading to diseases will likely result in clinical advancements, through the identification of sensitive genetic markers and the development of disease prevention and therapy (Saenko & Rogounovitch, ).…”

Section: Introductionmentioning

confidence: 99%

Effect of the thymine‐DNA glycosylase rs4135050 variant on Saudi smoker population

Almutairi

Alhadeq

Almeer

et al. 2019

Molec Gen & Gen Med

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Background Thymine‐DNA glycosylase (TDG) is an essential DNA‐repair enzyme which works in both epigenetic regulation and genome maintenance. It is also responsible for efficient correction of multiple endogenous DNA lesions which occur commonly in mammalian genomes. Research of genetic variants such as SNPs, resulting in disease, is predicted to yield clinical advancements through the identification of sensitive genetic markers and the development of disease prevention and therapy. To that end, the main objective of the present study is to identify the possible interactions between cigarette smoking and the rs4135050 variant of the TDG gene, situated in the intron position, among Saudi individuals. Methods TDG rs4135050 (A/T) was investigated by genotyping 239, and 235 blood specimens were obtained from nonsmokers and smokers of cigarette respectively. Results T allele frequency was found which showed a significant protective effect on Saudi male smokers (OR = 0.64, p = 0.0187) compared to nonsmoking subjects, but not in female smokers. Furthermore, smokers aged less than 29 years, the AT and AT+TT genotypes decreased more than four times the risk of initiation of smoking related‐diseases compare to the ancestral AA homozygous genotype. Paradoxically, the AT (OR = 3.88, p = 0.0169) and AT+TT (OR = 2.86, p = 0.0420) genotypes were present at a higher frequency in smoking patients aged more than 29 years as compared to nonsmokers at the same ages. Conclusion Depending on the gender and age of patients, TDG rs4135050 may provide a novel biomarker for the early diagnosis and prevention of several diseases caused by cigarette smoking.

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Section: Introductionmentioning

confidence: 99%

Effect of the thymine‐DNA glycosylase rs4135050 variant on Saudi smoker population

Almutairi

Alhadeq

Almeer

et al. 2019

Molec Gen & Gen Med

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“…It is also the second most common cause of death among women [2]. Over 1.7 million cases of breast cancer are diagnosed annually [3]. Numerous clinical and epidemiological studies have been conducted to better understand the etiology and molecular basis of the disease but the search for effective cancer therapies continues.…”

Section: Introductionmentioning

confidence: 99%

Expression profiling of genes modulated by rosmarinic acid (RA) in MCF-7 breast cancer cells

et al. 2018

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Objectives: Cancer is the second most common cause of death, with breast cancer (BC) as the most frequently diagnosed neoplasm among females. The origin of BC is multifactorial and depends on environmental and genetic factors. The disease presents a significant challenge due to its drug resistance and frequent metastasis. Thus, new effective therapies and metastasis prevention are much needed. Rosmarinic acid (RA) is a natural polyphenol which possesses the ability to inhibit BC cell proliferation and demonstrates cytotoxic properties against those cells. In our study, we examined the effect of RA on the expression of ZEB1, MDM2, ABCB1, PTEN and TWIST1 genes in MCF-7 breast cancer cells. Material and methods: MCF-7 cell cultures were treated with 0.2 µM doxorubicin (DOX) and 1.5, 15 or 50 µM of RA. Real-time PCR reaction was performed to analyze gene expression levels. Results: PCR analysis showed a significant increase of the ZEB1 gene expression, which was about 3-fold for DOX 0.2 µM, 9-fold for 0.2 µM DOX + 1.5 µM RA and 0.2 µM DOX + 15 µM RA (p < 0.05), and about 6.5-fold for 0.2 µM DOX + 50 µM RA (p < 0.05). Furthermore, a decrease of the MDM2 gene expression was observed in all of the examined variants and was about 40-75% (p < 0.05). No influence of DOX and RA combined with DOX on the ABCB1, TWIST1 and PTEN genes was found. Conclusions: The results of our study suggest that RA might be used as an adjuvant therapeutic factor in BC treatment.

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“…The was no significant correlation (P=0.542) and thus both are considered independent parameters. A study conducted by Paz et al [14] has shown the mean of 50 years at the time of diagnosis of carcinoma breast among the 100 cases studied. A study conducted by Cherry Bansal et al [15] has shown the mean of 55 years among the 45 cases studied.…”

Section: Discussionmentioning

confidence: 96%

Expression of Calretinin in Carcinoma Breast in Correlation with Various Histological and Molecular Subtypes

Hansini

Ganapathy

2021

JPRI

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Breast carcinoma is the second most common cancer following lung cancer. The incidence of cancer accounts for 24.2% and cancer death is about 15% among females. There are various prognostic and predictive factors for assessing the patient encountering carcinoma breast. Among the various prognostic factors, histological subtype and molecular subtype play a key role. The calretinin expression in carcinoma breast was seen in high-grade breast carcinomas and basal like subtype of carcinoma breast. Calretinin expression was predominantly noted in high grade II and III carcinomas as in other studies and other histological subtypes like metastatic carcinomas which are considered high grade tumours. The present study aimed to correlate the various clinicopathological parameters with the calretinin expression. The expression of Calretinin was seen mainly in grade II and grade III IDC- NST and metaplastic carcinomas. Among the molecular subtypes, the Basal like subtype and the Luminal B subtype showed calretinin expression. The calretinin expression was associated with tumours with a high proliferative index with Ki67 index >14%. This implies the importance of prognostic significance of calretinin expression, as cases with a high proliferative index are likely to have poor prognosis.

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Correlations between Risk Factors for Breast Cancer and Genetic Instability in Cancer Patients—A Clinical Perspective Study

Cited by 13 publications

References 68 publications

Effect of the thymine‐DNA glycosylase rs4135050 variant on Saudi smoker population

Effect of the thymine‐DNA glycosylase rs4135050 variant on Saudi smoker population

Expression profiling of genes modulated by rosmarinic acid (RA) in MCF-7 breast cancer cells

Expression of Calretinin in Carcinoma Breast in Correlation with Various Histological and Molecular Subtypes

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