Correlations Between the Level of High-Sensitivity C-Reactive Protein and Cardiovascular Risk Factors in Korean Adults with Cardiovascular Disease or Diabetes Mellitus: The CALLISTO Study

Seo, Suk Min; Baek, Sang Hong; Jeon, Hui Kyung; Kang, Seok-Min; Kim, Dong-Soo; Kim, Woo-Shik; Kim, Hyung Seop; Rha, Seung Woon; Park, Jong Seon; Seong, In Whan; Ahn, Young Keun; Yoon, Jung Han; Joon, Tae

doi:10.5551/jat.16089

Cited by 26 publications

(23 citation statements)

References 31 publications

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“…These results converge with the previous report of Seo et al [90] which showed that levels of hs-CRP are significantly correlated with the level of glycosylated hemoglobin, LDL/HDL ratio, LDL/total cholesterol (TC) ratio, and TC/TG ratio in diabetic patients or patients with CVD. Furthermore, Bahceci et al [91] observed positive correlation between serum hs-CRP and glycated hemoglobin in T2DM with or without CHD.…”

Section: Fig 2: Correlation Between Different Metabolic Parameters Asupporting

confidence: 92%

Clinical Significance of Procalcitonin and C-Reactive Protein in the Prediction of Cardiovascular Complications in Patients With Type 2 Diabetes Mellitus

Ahmed

Shousha

El-mezayen

et al. 2017

Asian J Pharm Clin Res

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Objective: This work was delineated to assess procalcitonin (PCT) and C-reactive protein (CRP) as prognostic markers for cardiovascular complication in type 2 diabetic patients.Methods: Forty diabetic patients without cardiovascular disease (CVD), 40 diabetic patients with CVD, and 20 healthy control counterparts were participated in this study. Serum PCT and CRP levels were assayed and correlated with metabolic parameters. Receiver operating characteristic (ROC) curve analysis was done for each biochemical marker. Results:The mean level of PCT was 707.17±99.19 ng/l in diabetic patients versus 881.30±123.56 ng/l for the cardio-diabetic patients (p<0.0001). The mean value of CRP was 34.43±17.27 mg/l in diabetic patients versus 50.32±20.19 mg/l for the cardio-diabetic patients (p=0.0003). PCT levels were significantly amplified in the cardio-diabetic patients with increasing CRP, triglycerides (TG), fasting blood glucose (FBG), and cholesterol (p=0.004, 0.0005, 0.002, and 0.01, respectively). CRP levels were significantly enhanced in the cardio-diabetic patients with increasing TG, FBG, cholesterol, and microalbumin (p=0.002, 0.047, 0.003, and 0.001 respectively). ROC curve analysis for PCT and CRP revealed that the area under curve (AUC) was 0.878 and 0.727, respectively. These findings indicate the good validity of the above biomarkers especially PCT as a prognostic marker for cardiovascular complication in type 2 diabetic patients. Conclusion:This study evidences the usefulness of measuring serum levels of PCT and CRP in diagnosis of cardiovascular complication in type 2 diabetic patients.

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Section: Fig 2: Correlation Between Different Metabolic Parameters Asupporting

confidence: 92%

Clinical Significance of Procalcitonin and C-Reactive Protein in the Prediction of Cardiovascular Complications in Patients With Type 2 Diabetes Mellitus

Ahmed

Shousha

El-mezayen

et al. 2017

Asian J Pharm Clin Res

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“…High-sensitivity C-reactive protein (hs-CRP) is produced by hepatocytes and is involved in inflammation. Clinical studies have demonstrated that hs-CRP levels can be used as predictors of cardiovascular disease (5). Matrix metalloproteinase 9 (MMP-9, also known as gelatinase B), which has numerous substrates, is involved in a wide range of physiological functions, including regulation of protease and cytokine activity (6).…”

Section: Introductionmentioning

confidence: 99%

Correlation between the severity of coronary artery lesions and levels of estrogen, hs-CRP and MMP-9

Guo

Zhang

Jun-biao

et al. 2014

Experimental and Therapeutic Medicine

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The aim of this study was to investigate the correlation between the severity of coronary artery lesions in patients with acute coronary syndromes (ACS) and levels of estrogen, high-sensitivity C-reactive protein (hs-CRP) and matrix metalloproteinase-9 (MMP-9). A total of 65 patients with ACS, 33 patients with stable angina pectoris (SAP) and 36 healthy controls were randomly enrolled. Patients with ACS were subdivided into two groups: Acute myocardial infarction (AMI; n=30) and unstable angina pectoris (UAP; n=35). Serum levels of estrogen, hs-CRP and MMP-9 were detected in the four groups of subjects. Serum estrogen levels in patients with AMI, UAP and SAP were significantly lower than those in the control group (P<0.05). Estrogen levels were also significantly different among the AMI, UAP and SAP groups (P<0.05), with a progressive increase across the three respective groups. Compared with healthy subjects, patients with AMI had the highest levels of hs-CRP and MMP-9, followed in descending order by those with UAP and SAP (P<0.05). Levels of hs-CRP and MMP-9 were also significantly different among the AMI, UAP and SAP groups (P<0.05). Serum estrogen levels were negatively correlated with hs-CRP and MMP-9 levels (r=−0.6634 and −0.6878, respectively; both P<0.05). hs-CRP and MMP-9 levels correlated positively (r=0.7208, P<0.05). The number of stenosed coronary vessels was negatively correlated with estrogen levels (r=−0.6467, P<0.05), and positively correlated with hs-CRP and MMP-9 levels (r=0.6519 and 0.6835, respectively; both P<0.05). In conclusion, serum estrogen, hs-CRP and MMP-9 levels were significantly correlated with the severity of coronary artery lesions. There was also a significant correlation between serum estrogen, hs-CRP and MMP-9 levels. These data indicate that serum estrogen, hs-CRP and MMP-9 have the potential to be used as biomarkers for evaluating the severity of coronary artery lesions and the stability of coronary artery plaques.

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“…Among patients without diabetes mellitus who were not receiving statin therapy, approximately 30% had CRP levels ≥3 mg/L, and approximately 50% had CRP levels ≥2 mg/L, including those at intermediate levels of traditionally estimated cardiovascular risk. Also, Seo SM, et al (53) found that the levels of hs-CRP were significantly increased from the low to the very high risk group (0.15, 0.23, 0.27 and 0.47, respectively) and were significantly correlated with age, BMI, the levels of HDL-ch, LDL-ch/HDL-ch ratio, the LDL-ch/total cholesterol (TC) ratio, the HDL-ch/TC ratio, the HDL-C/triglyceride (TG) ratio and the TC/TG ratio. In a multivariate regression analysis, age, the HDL-C level, the LDL-C/TC ratio and BMI were found to be independently correlated with the hs-CRP level.…”

Section: Discussionmentioning

confidence: 98%

Study the Correlation between Anthropometric Parameters and Biochemical Cardiovascular Risk Markers in Elderly Hypertensive Egyptian Patients

M.D¹,

Mahmood²

2015

JMSCR

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Correlations Between the Level of High-Sensitivity C-Reactive Protein and Cardiovascular Risk Factors in Korean Adults with Cardiovascular Disease or Diabetes Mellitus: The CALLISTO Study

Cited by 26 publications

References 31 publications

Clinical Significance of Procalcitonin and C-Reactive Protein in the Prediction of Cardiovascular Complications in Patients With Type 2 Diabetes Mellitus

Clinical Significance of Procalcitonin and C-Reactive Protein in the Prediction of Cardiovascular Complications in Patients With Type 2 Diabetes Mellitus

Correlation between the severity of coronary artery lesions and levels of estrogen, hs-CRP and MMP-9

Study the Correlation between Anthropometric Parameters and Biochemical Cardiovascular Risk Markers in Elderly Hypertensive Egyptian Patients

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