Correlations between umbilical and maternal serum adiponectin levels and neonatal birthweights

Chan, Te-Fu; Yuan, Shyng‐Shiou F.; Chen, Hung-Sheng; Guu, Chen-Feng; Wu, Lee-Chen; Yeh, Yao‐Tsung; Chung, Yueh-Fang; Jong, Shiang-Bin; Su, Jui Hsin

doi:10.1111/j.0001-6349.2004.0298.x

Cited by 81 publications

(92 citation statements)

References 12 publications

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“…Furthermore, umbilical vein serum adiponectin levels were three-fold higher than maternal serum adiponectin levels in normal pregnancy [14]. When adiponectin levels were measured in cord vein, a striking increase in plasma adiponectin concentrations with gestational age was noted [15]; concentrations at term were more than 20-fold higher compared with 24 weeks of gestation [15].…”

Section: Introductionmentioning

confidence: 88%

Secretion of adiponectin by human placenta: differential modulation of adiponectin and its receptors by cytokines

et al. 2006

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Aims/hypothesis: Pregnancy, a state of insulin resistance, is associated with elevated levels of cytokines and profound alterations in metabolism. Serum adiponectin, an adipokine with anti-inflammatory and insulinsensitising properties, has been shown to be lower in patients with gestational diabetes mellitus, a state of greater insulin resistance than normal pregnancies. Hypothesising that the human placenta is a source of adiponectin, we investigated its expression and secretion, and the regulation by cytokines of adiponectin and its receptors. Methods: Real-time RT-PCR, radioimmunoassay, Western blotting, radioligand binding and immunofluorescent analyses were applied to demonstrate the expression, secretion and functionality of placental adiponectin. Results: Adiponectin gene expression and protein were found in the human term placenta, with expression primarily in the syncytiotrophoblast. RIA of conditioned media from explant experiments revealed that the placenta can secrete adiponectin in vitro. Addition of conditioned media to HEK-293 cells transfected with the gene for adiponectin receptor-1 (ADIPOR1) altered the phosphorylation status of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase, an effect abolished after preabsorption with adiponectin antibody. Cytokines, including TNF-α, IFN-γ, IL-6 and leptin, differentially modulated placental adiponectin receptors as well as adiponectin gene expression and secretion. Interestingly, in placentae from women with gestational diabetes mellitus, we observed significant downregulation of adiponectin mRNA, significant upregulation of ADIPOR1 expression, and a non-significant increase in ADIPOR2 expression.Conclusions/ interpretation: Our results indicate that the human placenta produces and secretes adiponectin, and that adiponectin and its receptors are differentially regulated by cytokines and their expression altered in women with gestational diabetes mellitus. Collectively, our novel data suggest that adiponectin may play a role in adapting energy metabolism at the materno-fetal interface.

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Section: Introductionmentioning

confidence: 88%

Secretion of adiponectin by human placenta: differential modulation of adiponectin and its receptors by cytokines

et al. 2006

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“…Maternal adiponectin has a high molecular weight; therefore, it probably does not pass through the placental barrier; its concentration in the umbilical cord is of fetal origin (14,15). The origin of adiponectin in the fetus is not clearly understood (13).…”

Section: G Estational Diabetes Mellitus (Gdm) Is Impairedmentioning

confidence: 99%

“…In adults, adiponectin concentration is inversely related to adiposity, but its association with adiposity is poorly understood (9,11,13). Some studies indicate a positive correlation between cord plasma adiponectin concentration and adiposity in infants (8,12,14,(16)(17)(18)(19)(20) and some have found no significant correlation (9,15).…”

Section: G Estational Diabetes Mellitus (Gdm) Is Impairedmentioning

confidence: 99%

Relation between fetal anthropometric parameters and cord blood adiponectin and high-sensitivity C-reactive protein in gestational diabetes mellitus

Aramesh

Dehdashtian

Malekian

et al. 2017

Arch. Endocrinol. Metab.

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Objectives:The objectives were to evaluate the relation between fetal anthropometric parameters and cord blood concentration of adiponectin and high sensitivity C-reactive protein (hs-CRP). Subjects and methods: A total of 104 pregnant women (52 with gestational diabetes mellitus [GDM], 52 with normal glucose tolerance (NGT) participated. Venous cord blood samples were obtained at delivery, centrifuged and the plasma was stored at -20°C. The samples were assessed for adiponectin and hs-CRP using the ELISA method. Statistical analysis was done using SPSS software. Results: The adiponectin concentration was higher in the GDM group than in the NGT group (11.05 ± 4

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“…6,7 Some investigators have reported a significant positive relationship between birth weight, as a proxy mirror of the intrauterine environment, and cord blood adiponectin levels. [8][9][10] Our previous study demonstrated that the serum adiponectin levels on the first day of life were significantly higher in appropriate-for-gestational-age birth weight (AGA) than in small-for-gestational-age birth weight (SGA) term neonates. 11 Although adiponectin levels in the cord blood of term infants are extensively higher than in children or adults, its exact physiological role in regulating intrauterine fetal growth has not been fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

“…11 Although adiponectin levels in the cord blood of term infants are extensively higher than in children or adults, its exact physiological role in regulating intrauterine fetal growth has not been fully elucidated. 8,9,12 On the other hand, epidemiological studies have revealed that there is a relationship between fetal growth retardation and the subsequent development of insulin resistance later in life. 13,14 Single-nucleotide polymorphisms (SNPs) in the adiponectin gene (ADIPOQ) have been associated with adiponectin levels, changes in insulin sensitivity and risk for type 2 diabetes mellitus and coronary artery disease.…”

Section: Introductionmentioning

confidence: 99%

Association of adiponectin polymorphism with cord blood adiponectin concentrations and intrauterine growth

et al. 2011

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To assess whether adiponectin gene (ADIPOQ) polymorphism is associated with intrauterine fetal growth and cord blood adiponectin, we investigated eight single-nucleotide polymorphisms (SNPs; rs182052, rs710445, rs16861205, rs12495941, rs1501299, rs3774261, rs2082940 and rs266729) in ADIPOQ and birth weight and cord blood adiponectin in 526 healthy neonates. We found that the neonates carrying the G allele of rs266729 had a significantly greater birth weight s.d. score than those homozygous for the C allele (CC: À0.06 ± 0.75 versus CG: 0.20 ± 0.64 versus GG: 0.07 ± 0.78; P¼1.65Â10 À3 , adjusted P¼9.90Â10 À3 ). However, this difference was not significant after adjustment for cord blood adiponectin (P¼0.04, adjusted P¼0.26). The rs266729 SNP was strongly associated with cord blood adiponectin; neonates with rs266729 GG had the highest adiponectin (CC: 34.1 ± 20.2 versus CG: 44.3 ± 26.1 versus GG: 54.1 ± 36.7 lg ml -1 , P¼2.80Â10 À9 , adjusted P¼1.68Â10 À8 ). This association remained after adjustment for birth weight s.d. score (P¼6.63Â10 À8 , adjusted P¼3.98Â10 À7 ). Our results suggest that the influence of the rs266729 SNP in ADIPOQ on birth weight may be dependent on circulating adiponectin.

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Correlations between umbilical and maternal serum adiponectin levels and neonatal birthweights

Cited by 81 publications

References 12 publications

Secretion of adiponectin by human placenta: differential modulation of adiponectin and its receptors by cytokines

Secretion of adiponectin by human placenta: differential modulation of adiponectin and its receptors by cytokines

Relation between fetal anthropometric parameters and cord blood adiponectin and high-sensitivity C-reactive protein in gestational diabetes mellitus

Association of adiponectin polymorphism with cord blood adiponectin concentrations and intrauterine growth

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