Correlations of adiponectin level with insulin resistance and atherosclerosis in Japanese male populations

Higashiura, Katsuhiro; Ura, Nobuyuki; Ohata, Junichi; Togashi, Nobuhiko; Takagi, Satoru; Saitoh, Shigeyuki; Murakami, Hideyuki; Takagawa, Yoshitoki; Shimamoto, Kazuaki

doi:10.1111/j.1365-2265.2004.02165.x

Cited by 59 publications

(39 citation statements)

References 42 publications

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“…Adiponectin is exclusively secreted by adipocytes, circulates at relatively high levels in the bloodstream and appears to play an important role in pathophysiology of obesity, type 2 diabetes and coronary artery disease (1)(2)(3)(4)(5)(6)(7). Adiponectin levels are decreased in obesity and are inversely correlated to insulin resistance (5,(8)(9)(10)(11). Furthermore, low serum adiponectin levels are associated with a markedly increased risk of atherosclerotic disease like coronary artery disease (4)(5)(6)(7)(8)12).…”

Section: Introductionmentioning

confidence: 99%

Elevated serum levels of adiponectin in children, adolescents and young adults with type 1 diabetes and the impact of age, gender, body mass index and metabolic control: a longitudinal study

Galler¹,

Gelbrich²,

Kratzsch³

et al. 2007

eur j endocrinol

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Objective: Adiponectin plays an important role in pathophysiology of obesity, type 2 diabetes and cardiovascular disease. The aim of this study was to determine adiponectin concentrations in children and adolescents with type 1 diabetes in a longitudinal manner and to study the impact of age, gender, body mass index (BMI) and metabolic control. Research design and methods: In this study, 88 children and adolescents with type 1 diabetes were followed longitudinally. At baseline and during follow-up, serum levels of adiponectin were measured by enzyme-linked immunoassay and correlated with clinical data, HbA1c and lipids. Healthy children (nZ259) were chosen as a control group. Results: Serum adiponectin levels were significantly higher in children with type 1 diabetes compared with healthy children (13.1 vs 9.1 mg/ml at baseline, P!0.001). Adiponectin concentrations inversely correlated with BMI S.D.s (P!0.001). No significant difference of adiponectin levels regarding gender, diabetes duration or HbA1c was seen. Adiponectin concentrations decreased in males with type 1 diabetes during puberty (PZ0.03) while there was no significant change in females. In a subgroup of patients with new onset type 1 diabetes, adiponectin concentrations were not different from adiponectin levels in control subjects but increased during follow-up (PZ0.007). Stepwise multiple regression analysis showed that most important predictors of adiponectin levels in type 1 diabetes at the end of the study were adiponectin concentration at baseline (bZ0.574, P!0.001) and BMI S.D.s (bZK0.302, PZ0.001, r 2 Z0.56). Conclusions: Children and adolescents with type 1 diabetes have BMI-dependent elevated serum concentrations of adiponectin compared with healthy children.European Journal of Endocrinology 157 481-489

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Section: Introductionmentioning

confidence: 99%

Elevated serum levels of adiponectin in children, adolescents and young adults with type 1 diabetes and the impact of age, gender, body mass index and metabolic control: a longitudinal study

Galler¹,

Gelbrich²,

Kratzsch³

et al. 2007

eur j endocrinol

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show abstract

“…Obez insanlarda da adiponektin seviyelerinde düşüş izlenir. İnsülin direnci ve yüksek duyarlıklı CRP arttıkça adiponektin düzeyleri azalmaktadır (37). Literatürde yüksek adiponektin seviyesi olan bireylerde tip 2 diyabet gelişme riskinin adiponektin seviyeleri düşük olan kişilerden daha az olduğu bildirilmektedir (38).…”

Section: Adiponektinunclassified

New adipokines: Leptin, adiponectin and omentin

Aktaş¹,

Şit²,

Tekçe³

2013

Turk J Bioch

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“…Plasma adiponectin levels have been shown to closely correlate with the level of insulin sensitivity. 48,49 Not surprisingly, patients with NASH show decreased levels of circulating adiponectin. 50 It is possible that an antiinflammatory effect mediated by adiponectin may influence the regression of local hepatic inflammation and necrosis.…”

Section: Adiponectinmentioning

confidence: 99%

Non-alcoholic Steatohepatitis—An Endocrine Disorder

Balas¹,

Ali²,

Cusi³

2007

US Endocrinology

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Correlations of adiponectin level with insulin resistance and atherosclerosis in Japanese male populations

Abstract: The results suggest that adiponectin plays a role in lipid metabolism and correlates with atherosclerosis either directly or through insulin resistance.

Cited by 59 publications

References 42 publications

Elevated serum levels of adiponectin in children, adolescents and young adults with type 1 diabetes and the impact of age, gender, body mass index and metabolic control: a longitudinal study

Elevated serum levels of adiponectin in children, adolescents and young adults with type 1 diabetes and the impact of age, gender, body mass index and metabolic control: a longitudinal study

New adipokines: Leptin, adiponectin and omentin

Non-alcoholic Steatohepatitis—An Endocrine Disorder

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