Correlations of ER, PR, Her-2 and CK5/6 expression with histological characteristics features and prognosis of breast ductal carcinoma in situ

Abstract

This study aimed to investigate the correlations of Estrogen Receptor (ER), Progesterone Receptor (PR), human epidermal growth factor receptor 2 (Her-2) and cytokeratin 5/6 (CK5/6) protein expression with histological characteristics features and prognosis of breast Ductal Carcinoma in situ (DCIS). Fortyeight cases of breast DCIS specimen were enrolled in this study. The samples were histologically typed and graded. The immunohistochemical analysis was performed to determine the expression of ER, PR, Her-2 and CK5/6 protein. Results showed that, the positive rates of ER and PR protein expression in non-comedo type DCIS group were significantly higher than those in comedo type DCIS group, respectively (P<0.05), and the positive rate of Her-2 protein expression in non-comedo type group was significantly lower than that in comedo type group (P<0.05). There was no significant difference of CK5/6 protein expression between two groups (P>0.