Correlations of Gene Variants LEP &lt;i&gt;rs2167270&lt;/i&gt;, LEPR &lt;i&gt;rs1137100&lt;/i&gt;, GHRL &lt;i&gt;rs696217&lt;/i&gt;, &lt;i&gt;rs27647&lt;/i&gt;, and NPY &lt;i&gt;rs16147&lt;/i&gt; with Obesity and Adolescent Eating Behavior: Case-Control Study

Кочетова, О. В.; Shangareeva, Z. A.; Викторова, Т. В.; Korytina, G. F.; Викторов, В. В.

doi:10.15690/vsp.v21i3.2428

Cited by 3 publications

(1 citation statement)

References 37 publications

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“…Кочетовой и соавт. (2022) показано, что варианты rs2167270 гена лептина (р=0,015), rs696217 гена грелина (р=0,040) и rs16147 гена нейропептида Y (р=0,020) ассоциированы с ПП детей и подростков, предрасполагающим к развитию ожирения [24]. В доступной литературе нами не найдено публикаций, посвященных изучению вклада носительства полиморфных локусов генов, контролирующих энергетический обмен, в особенности ПП детей первых лет жизни.…”

Section: рис 1 механизмы контроля аппетита [2] Fig 1 Appetite Control...unclassified

Associations of Leptin, Leptin Receptor, Insulin, and Interleukin-6 Gene Variants with Anthropometric Status and Eating Behavior in Young Children

Прилуцкая¹,

Павлович²

2023

Педиатрия. Восточная Европа

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Цель. Оценить ассоциации вариантов (генотипов и аллелей) генов лептина, рецептора лептина, инсулина и интерлейкина-6 с антропометрическим статусом и пищевым поведением (ПП) детей раннего возраста. Материалы и методы. Обследовано 106 детей раннего возраста. Выделены группы детей с учетом МТ при анкетировании (с избыточной и нормальной массой) и при рождении (крупновесные к сроку гестации, маловесные к сроку гестации и соответствующие сроку). Расчет и оценка показателей физического развития проведены с использованием программы ВОЗ Anthro. Определяли варианты (генотипы и аллели) генов лептина (LEP), рецептора лептина (LEPR), инсулина (INS) и интерлейкина-6 (IL-6). ПП оценивали с помощью опросника для родителей CEBQ. Результаты. Анализ распределения вариантов генов у 37 детей с избыточной массой тела и 69 младенцев группы сравнения выявил ассоциацию с избыточным весом варианта rs2167270 гена LEP (р=0,022). Ассоциации с МТ при рождении установлены для генотипа GG гена IL-6 в группах маловесных и нормовесных к сроку гестации (р=0,050 и р=0,039). Анализ шкал опросника пищевого поведения показал значимые различия по показателям, способствующим развитию ожирения. Носители генотипа AA гена INS имели более высокие баллы по критерию «желание пить» (р=0,033). Параметр «ощущение сытости» у детей, имеющих генотип GC гена IL-6, составил 3 (3–4) балла, GG – 3 (3–4), CC – 4 (3–4) балла (р=0,046). Показатель «эмоциональное недоедание» у обладателей генотипа GC гена IL-6 – 3 (2–4), GG – 3 (3–4), CC – 4 (3–4) балла (р=0,007). Значимые различия установлены по критерию «эмоциональное переедание» для гена LEPR (р=0,045). Заключение. Полученные результаты свидетельствуют о роли наследственных факторов в поддержании физического статуса и формировании пищевого поведения детей раннего возраста. Purpose. To analyze associations of leptin, leptin receptor, insulin, and interleukin-6 genes variants (genotypes and alleles) with anthropometric status and eating behavior (EB) in young children. Materials and methods. A total of 106 infants were examined. Groups of children were distinguished taking into account the body weight (BW) during the survey (overweight and normal weight) and at birth (large weight by gestational age, low weight by gestational age, and appropriate weight by gestational age). Calculations and assessment of physical development indicators were performed using the WHO Anthro program. Leptin (LEP), leptin receptor (LEPR), insulin (INS), and interleukin-6 (IL-6) genes variants (genotypes and alleles) were determined. EB was assessed using the Children’s Eating Behavior Questionnaire (CEBQ) for parents. Results. The analysis of genes’ variant distribution in 37 overweight children and 69 infants of the comparison group revealed an association of rs2167270 variant of LEP gene with overweight (p=0.022). Associations with birth weight were found for GG genotype of IL-6 gene in the underweight and appropriate weight groups by gestational age (p=0.050 and p=0.039). CEBQ scores analysis showed significant differences in indicators contributing to obesity. AA genotype carriers of INS gene had significantly higher "desire to drink" criterion scores (p=0.033). The The "satiety responsiveness" parameter in children with GC genotype of IL-6 gene scored 3 (3–4), with GG genotype scored 3 (3–4), and with CC genotype scored 4 (3–4) (p=0.046). The "emotional undereating" indicator in IL-6 gene GC genotype carriers was 3 (2–4) points, in those of GG 3 (3–4), and in those of CC 4 (3–4) points (p=0.007). Statistically significant differences were established in "emotional overeating" criterion for the LEPR gene (p=0.045). Conclusion. The results obtained suggest the role of hereditary factors in the maintenance of physical status and formation of eating behavior in early childhood.

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Section: рис 1 механизмы контроля аппетита [2] Fig 1 Appetite Control...unclassified

Associations of Leptin, Leptin Receptor, Insulin, and Interleukin-6 Gene Variants with Anthropometric Status and Eating Behavior in Young Children

Прилуцкая¹,

Павлович²

2023

Педиатрия. Восточная Европа

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Targeted Sequencing of the LEP Gene in Various Ethnic Groups of Obese Adolescents

Belyaeva,

Bairova,

Ershova

et al. 2024

Russ J Genet

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Association of polymorphic variants of the leptin gene with anthropometric and biochemical parameters in adolescents with different weight status

Ershova,

Bairova,

Sambyalova

et al. 2024

Acta biomedica scientifica

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The leptin gene (LEP) is considered as a potential candidate gene affecting metabolic disorders associated with predisposition to overweight and obesity.The aim of the study. To search for single nucleotide polymorphisms (SNP) of the leptin gene and to assess their relationship with anthropometric and biochemical parameters in Russian and Buryat adolescents with different weight status.Materials and methods. The study included adolescents of two ethnic groups – Caucasoid (Russians) and Mongoloids (Buryats) – aged 11–17 years (mean age 14.8 ± 0.45 years) with different weight status. We assessed anthropometric parameters, determined biochemical parameters and leptin level in the blood plasma, and sequenced the leptin gene fragment localized in the 128253475–128255334 region (1859 bp) of this gene using the Sanger method.Results. The sequencing of the leptin gene fragment identified 10 single nucleotide substitutions (rs28954118, rs3828942, rs759854910, rs199893150, rs7788818, rs144755411, rs917105894, chr7:128255051, chr7:128255092, chr7:128254681), two of them (rs28954118, rs144755411) had a correlation with biochemical and anthropometric parameters. In the group of Russian adolescents with overweight and/or obesity, the carriers of the AT variant of rs28954118 had statistically significantly higher levels of triglycerides (TG), very low density lipoprotein (VLDL) cholesterol, skin fold thickness on the abdomen and fat mass percentage compared with carriers of the AA genotype. In the control group of Buryat adolescents, the parameters of waist width, skin fold thickness on the hip and waist width/height ratio are statistically significantly lower in carriers of the CT variant of rs144755411 compared with carriers of the CC genotype.Conclusion. AT genotype of rs28954118 was identified only in Russian adolescents with overweight and/or obesity, and was accompanied with statistically significantly high values of TG, VLDL cholesterol, skin fold thickness on the abdomen and fat mass percentage. The SNPs we identified do not affect the concentration of leptin.

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Correlations of Gene Variants LEP <i>rs2167270</i>, LEPR <i>rs1137100</i>, GHRL <i>rs696217</i>, <i>rs27647</i>, and NPY <i>rs16147</i> with Obesity and Adolescent Eating Behavior: Case-Control Study

Cited by 3 publications

References 37 publications

Associations of Leptin, Leptin Receptor, Insulin, and Interleukin-6 Gene Variants with Anthropometric Status and Eating Behavior in Young Children

Associations of Leptin, Leptin Receptor, Insulin, and Interleukin-6 Gene Variants with Anthropometric Status and Eating Behavior in Young Children

Targeted Sequencing of the LEP Gene in Various Ethnic Groups of Obese Adolescents

Association of polymorphic variants of the leptin gene with anthropometric and biochemical parameters in adolescents with different weight status

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