Correlations of CTLA‐4 exon‐1 49 A/G and promoter region 318C/T polymorphisms with the therapeutic efficacy of ¹³¹I radionuclide in graves’ disease in Chinese Han population

Abstract

Graves' disease is an autoimmune process in which the thyroid gland is triggered by autoantibodies, resulting in hyperthyroidism. The purpose of the present study is to elucidate whether exon-1 49 A/G and promoter region 318C/T polymorphisms in the CTLA-4 gene. This study consisted of 653 eligible patients with Graves' disease. After receiving 131I radionuclide therapy, these patients were classified into the remission and non-remission groups. A logistic regression-based model was used to analyze independent factors affecting the patient response to 131I radionuclide therapy. The results showed that CTLA-4 49 A/G was closely related to the efficacy of I treatment for Graves' disease (AG + GG vs. AA: OR = 6.543, 95%CI = 2.611 ∼ 16.40, P< 0.001; G vs. A: OR = 3.482, 95%CI = 2.457 ∼ 4.934, P < 0.001). Moreover, the findings revealed that haplotype A-C (P < 0.001, OR = 3.592, 95%CI: 2.451 ∼ 5.262) and G-C (P < 0.001, OR = 0.282, 95%CI: 0.204 ∼ 0.391) were associated with the efficacy of I therapy in treating Graves' disease. Logistic regression analysis indicated that thyroid weight (OR = 0.963, 95%CI = 0.944 ∼ 0.982, P< 0.001) and CTLA-4 exon-1 49 A/G polymorphism (OR = 0.334, 95%CI = 0.233 ∼ 0.478, P < 0.001) independently affect the efficacy of I therapy in Graves' disease. These data indicated that CTLA-4 exon-1 49 A/G polymorphism may be associated with patient response to radionuclide I therapy in Graves' disease.

Association of Polygenetic Risk Scores Related to Immunity and Inflammation with Hyperthyroidism Risk and Interactions between the Polygenetic Scores and Dietary Factors in a Large Cohort

“…Hyperthyroidism is a condition that involves excessive productions of tetraiodothyronine (T4) and/or triiodothyronine (T3) by the thyroid gland and low serum levels of thyroid-stimulating hormone (0–0.4 mU/L; TSH) [ 1 ]. Graves' disease (an autoimmune disorder), Plummer's disease, and thyroiditis (thyroid gland inflammation) accompany hyperthyroidism [ 2 ]. The prevalence of Graves's disease and thyroid inflammation is linked to ethnicity [ 3 ].…”