The high prevalence of pathologies of the dental and tooth-jaw system both in Ukraine and abroad requires scientists to search for new, fundamental discoveries, in particular, to identify patterns of the relationship between cephalometric and odontometric indicators within certain ethnic populations. The purpose of the study is to establish the features of the correlations of computed tomography sizes of molars with cephalometric parameters of practically healthy men in the southern region of Ukraine. 33 practically healthy men of the first mature age, inhabitants of the southern region of Ukraine (from Mykolayiv, Kherson, Odesa, Zaporizhia regions and the Autonomous Republic of Crimea) underwent cephalometry and cone-beam computed tomography followed by odontometry of molars. The correlations between odonto- and cephalometric parameters were assessed in the license package “Statistica 6.1” using non-parametric Spearman statistics. In almost healthy men of the southern region of Ukraine in the qualitative analysis of multiple nature, mostly direct reliable and medium unreliable correlations, found only between most sizes of molars on the lower jaw and the length and height of the nose. Quantitative analysis revealed the most significant correlations between computed tomography sizes of molars and face sizes (7.4 % on the upper jaw, most of which are inverse, and 13.2 % on the lower jaw, almost evenly straight and inverse). With the indicators of the skull, the relative majority of reliable, mostly inverse correlations are observed with the height of the teeth, their crowns and the length of the roots (on the upper jaw 11.4 %, on the lower jaw 5.4 %); and with indicators of the facial skull – almost evenly with the height of the teeth, their crowns and the length of the roots (on the upper jaw 6.4 %, on the lower jaw 14.6 %, in both cases mostly reverse) and with vestibular-lingual and mesio-distal dimensions (on the upper jaw 8.7 %, mostly reverse, on the lower jaw 11.8 %, mostly straight). The obtained results of correlation analysis of computed tomography sizes of molars with cephalometric indicators and indices confirm the population specificity of the features of the dental system and are necessary for the correct construction of regression models.