Correlations of maternal neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) with birth weight

Akgün, Nilüfer; Kalem, Müberra Namlı; Yüce, Ebru; Kalem, Ziya; Aktas, Hatice

doi:10.1080/14767058.2016.1237497

Cited by 35 publications

(43 citation statements)

References 24 publications

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“…However, there are few studies showing the effect of hematological parameters and obtained values. Increased WBC values are also associated with poor obstetric outcomes and low birth weight [6,30]. Similarly, in the present study, WBC values were found to be higher in the group with FGR.…”

Section: Discussionsupporting

confidence: 84%

“…A power analysis was conducted using the G * Power version 3.1.7 software and based on findings of comparable studies [6,17]. An effect size of 0.462 was used with power set at 0.80 and alpha at 0.05 to determine that a sample size of n = 59 was required in each group to conduct Student's t-test.…”

Section: Methodsmentioning

confidence: 99%

“…Idiopathic FGR has been usually associated with placental insufficiency [5]. Therefore, studies on the etiology mostly focus on changes in uteroplacental hemodynamics [6]. Especially early-onset FGR is more closely associated with preeclampsia pathophysiology and develops as a result of the changes in the placental bed.…”

Section: Introductionmentioning

confidence: 99%

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Can Inflammatory Hematological Parameters be a Guide to Late-onset Fetal Growth Restriction?

Kırmızı

Başer

Onat

et al. 2020

Z Geburtshilfe Neonatol

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Purpose To compare the rates obtained from hematological parameters in cases of late-onset idiopathic fetal growth restriction (FGR) with healthy pregnancies and to evaluate the effect on neonatal outcomes. Methods The study group consisted of 63 pregnant women with late-onset idiopathic FGR and the control group consisted of 91 healthy pregnant women. The determined rates were calculated from the control hemograms of patients at 28 weeks. Both groups were compared for neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and other parameters. Results NLR, leukocyte and neutrophil levels were significantly higher in the FGR group (p<0.05). There was no significant difference in PLR, platelet and lymphocyte levels between the groups (p>0.05). To predict FGR, the best cut-off value of NLR was determined to be 4.11 with 56% sensitivity and 88% specificity values. Conclusion Neutrophil, lymphocyte and platelet interactions have an important role in FGR development. Inflammation can be involved in the etiopathogenesis in late-onset FGR.

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Section: Discussionsupporting

confidence: 84%

Section: Methodsmentioning

confidence: 99%

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Can Inflammatory Hematological Parameters be a Guide to Late-onset Fetal Growth Restriction?

Kırmızı

Başer

Onat

et al. 2020

Z Geburtshilfe Neonatol

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“…47,48 Previous studies have also shown that maternal inflammation affects birth weight either directly or via preterm labour. [49][50][51] In light of these findings, an increased NLR and PLR can be a result of preterm labour or insufficiency of the maternal-placental-foetal unit. A study that investigated the NLR and PLR in preeclamptic patients found a correlation between the PLR, but not the NLR, and the severity of preeclampsia.…”

Section: Discussionmentioning

confidence: 99%

Importance of haemogram parameters for prediction of the time of birth in women diagnosed with threatened preterm labour

Tolunay

Elçi

2020

J Int Med Res

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Objective: This study aimed to estimate the importance of complete blood count parameters for predicting the timing of birth in threatened preterm labour cases. Methods: We performed a retrospective study of 92 patients who were diagnosed with threatened preterm labour (24-34 gestational weeks). The patients were divided into two groups according to the time of birth (group 1: delivered within the first week after diagnosis; group 2: delivered later than 1 week). We compared characteristics and complete blood count parameters between these two groups.Results: There were no significant differences in maternal age, body mass index, gravida, parity, haemoglobin levels, and gestational weeks between the two groups. The mean cervical length was 24.24 AE 3.60 mm in group 1 and 30.70 AE 5.32 mm in group 2. There were significant differences in the neutrophil to lymphocyte ratio, white blood cell count, red cell distribution width (RDW), absolute lymphocyte cell count, and absolute neutrophil cell count between the two groups. Conclusion: Maternal serum RDW, the neutrophil to lymphocyte ratio, white blood cell count, absolute lymphocyte cell count, and the absolute neutrophil cell count profile could guide clinicians in predicting the time of birth in threatened preterm labour cases. KeywordsRed cell distribution width (RDW), neutrophil to lymphocyte ratio (NLR), mean platelet volume (MPV), preterm birth, delivery, cervical length, white blood cells Date

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“…Similarly, inflammation has been implicated in the etiology of early membrane rupture cases (3) . In the literature, the results studies evaluating the effect of PLR on neonatal outcomes vary (4,5) . The variable results can be attributed to maternal obstetric conditions (such as preterm labor, pre-eclampsia) and the different source of the blood sample (maternal/ fetal).…”

Section: To the Editormentioning

confidence: 99%

Letter to Editor

Kırmızı¹,

Onat²,

Başer³

et al. 2020

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Correlations of maternal neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) with birth weight

Abstract: This prospective study is the first in the literature which investigates the correlation of NLR and PLR with the week of birth and birth weight of the infant. Our study suggested that the maternal NLR and PLR are negatively correlated with the week of birth and birth weight of the infant.

Cited by 35 publications

References 24 publications

Can Inflammatory Hematological Parameters be a Guide to Late-onset Fetal Growth Restriction?

Can Inflammatory Hematological Parameters be a Guide to Late-onset Fetal Growth Restriction?

Importance of haemogram parameters for prediction of the time of birth in women diagnosed with threatened preterm labour

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