Correlations of Vibrio fischeri Bacteria Test Data with Bioassay Data for Other Organisms

Abstract

Linear relationships of the median lethal concentrations of several hundreds of chemicals for a variety of organisms with Vibrio fischeri median effective concentrations are investigated. Significant correlations can be developed for many aquatic species including the fishes fathead minnow, bluegill, catfish, goldfish, goldorfe, guppy, killifish, rainbow trout, sheepshead minnow, and zebrafish; the water flea Daphnia sp.; such crustaceans as Artemia sp. and Crangon sp.; the ciliate Tetrahymena pyriformis; and algae, such as Chlorella sp. These interspecies relationships can be used to estimate order-of-magnitude type toxic effects of many substances for these aquatic organisms. Highly significant relationships can be obtained when selecting compounds on a chemical basis, such as alcohols, ketones, aromatics, etc., which allow the calculation of the compounds' toxicities to the corresponding aquatic species with increased accuracy and confidence. Analogous correlations with mammalian (rat and mouse) oral, intraperitoneal, and intravenous median lethal dose (LD50) data are much weaker than those for most aquatic species.However, there are significant differences between these three routes of administration and the intravenous LD50 data show the best relationship with the Vibrio data. Environ Health Perspect 106(Suppl 2):583-591 (1998). http:/lehpnetl.niehs.nih.govldocs/1998/Suppl-2/583-591 kaiserlabstract.html

Toxicity of betulin derivatives and in vitro effect on promastigotes and amastigotes of Leishmania infantum and L. donovani

“…The V. fischeri bacteria test (Microtox) has been found to be correlated with other tests in higher organisms. 30 However, in our case, no relationship was found.…”

Assessment of the potential toxicity of herbicides and their degradation products to nontarget cells using two microorganisms, the bacteria Vibrio fischeri and the ciliate Tetrahymena pyriformis

“…This test is used to screen toxicity of pure chemicals, complex mixtures or natural samples, toward a sample of prokaryotic organisms, which fulfill critical roles in nutrient cycling within different environmental ecosystems. Significant interspecies relationships have been obtained between V. fischeri bacteria test data and bioassay data for other organisms (Kaiser, 1998).…”

A review on advantages of implementing luminescence inhibition test (Vibrio fischeri) for acute toxicity prediction of chemicals

“…The growing interest in these tests is due to the fact that, despite the existence of different toxicity mechanisms for various organisms of different species, a substance that is toxic for an organism often demonstrates similar toxic effects on other organisms (Kaiser, 1998). Thus, luminescence inhibition in a bacterium can effectively indicate toxic effects on higher organisms.…”