Correlative study of blood coagulation and serum lipids in diabetics without clinically recognizable complications

Ghanem, M. H.; Tawfik, Shady H.; Guirgis, F. K.; El-Sawy, M.

doi:10.1016/0021-9150(71)90056-6

Atherosclerosis

1971

DOI: 10.1016/0021-9150(71)90056-6

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Correlative study of blood coagulation and serum lipids in diabetics without clinically recognizable complications

M. H. Ghanem

Shady H. Tawfik

F. K. Guirgis

et al.

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1976

1979

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Cited by 4 publications

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“…Some recent reports are available on individual lipid fractions in diabetes. Ghanem et al (1971) have correlated phospholipid and non-esterified fatty acid levels with increased blood coagulation in diabetes: Walaas et al (1971) have also studied serum phospholipids in diabetic patients. Lloyd (1970) has reported serum lipid studies in diabetic children and Shapiro et al (1973) have compared serum cholesterol and triglyceride concentrations in White and Bantu diabetics (1973).…”

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confidence: 98%

A Lipid and Lipoprotein Profile of Treated and Untreated Diabetics

1976

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A group of 149 diabetics and 98 healthy subjects without evidence of diabetes or ischaemic heart disease were studied. Untreated diabetics under 40 years old and 40 years of age and over showed statistically raised fasting serum turbidity, triglycerides, and raised beta and pre-beta lipoprotein levels but not raised cholesterol levels over the age and sex matched normal subjects. Further, some 63% of all diabetics showed a distinct split pre-beta lipoprotein pattern as seen on polyacrylamide disc electrolphoresis as compared with 17% in the control group. Raised lecithin and phosphatidylethanolamine (PE) levels were found in male diabetics and raised PE levels in young diabetic women. In patients under treatment with insulin, chlorpropamide, or phenformin the diabetes was well controlled in most cases, but these patients did not have significantly lower lipid levels. Diabetics on a low carbohydrate diet showed improvement in triglycerides and pre-beta lipoprotein levels, but beta lipoproteins were not lowered. It is suggested that diabetics may benefit by the inclusion of clofibrate in the treatment.

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A Lipid and Lipoprotein Profile of Treated and Untreated Diabetics

1976

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Coagulation abnormalities in diabetic coma before and 24 hours after treatment

1979

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Smnmary. A coagulation screen consisting of measurement of the prothrombin time, thrombin time, kaolin cephalin dotting time, platelet count, plasma fibrinogen level, fibrin degradation products and ethanol gelation test was performed on 24 patients with impairment of consciousness due to acute diabetic metabolic decompensation at the start of treatment and 24 hours later. 22 out of 24 patients showed at least one coagulation abnormality on admission of which the commonest were a prolonged prothrombin time, shortened kaolin cephalin clotting time and raised plasma fibrinogen level. After 24 hours of treatment these values were more normal but 20 out of 22 patients still displayed some abnormality. 15 patients had two or more coagulation abnormalities on admission including 3 patients with haematological abnormalities suggestive of disseminated intravascular coagulation. This group was older and had higher blood ureas than those with fewer abnormalities, but plasma glucose, sodium, potassium and bicarbonate levels were similar in both groups of patients. All 5 patients with hyperosmolar non-ketotic coma and all 3 patients who died without recovering consciousness had two or more coagulation abnormalities on admission.

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The automated determination of serum phospholipids

Taylor

Watts

1976

Clinica Chimica Acta

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Correlative study of blood coagulation and serum lipids in diabetics without clinically recognizable complications

Cited by 4 publications

References 12 publications

A Lipid and Lipoprotein Profile of Treated and Untreated Diabetics

A Lipid and Lipoprotein Profile of Treated and Untreated Diabetics

Coagulation abnormalities in diabetic coma before and 24 hours after treatment

The automated determination of serum phospholipids

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