Correlative Study of Human Papillomavirus DNA, Histopathology, and Morphometry in Cervical Condyloma and Intraepithelial Neoplasia

Fu, Yao; Huang, Irene; Beaudenon, Sylvie; Ionesco, M; Barrasso, R; Brux, J. De; Orth, Gérard

doi:10.1097/00004347-198812000-00001

Cited by 31 publications

(9 citation statements)

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“…5 The degree of intraepithelial neoplasia (grades I to III/in situ carcinoma) was judged on the degree of atypical cellular aspects and their topography within the epithelium as for cervical intraepithelial neoplasia. 6 …”

Section: Histological Examinationmentioning

confidence: 99%

Comparison of clinical, histological, and virological symptoms of HPV in HIV-1 infected men and immunocompetent subjects

Aynaud¹,

Piron²,

Barrasso³

et al. 1998

Sexually Transmitted Infections

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Objective:We assessed the clinical, histological, and virological features of anogenital human papillomavirus (HPV) infection, according to their immune status in HIV-1 infected men, referred for an anogenital examination or treatment, in comparison with immunocompetent patients. Methods: The study population comprised 33 HIV-1 infected heterosexual or homosexual men and 38 HIV negative men seen in a screening and treatment centre for anogenital HPV infections. All patients were examined with a colposcope. Biopsies were carried out on all subjects with anogenital lesions for histological studies and HPV detection by Southern blot. Results: The HIV infected patients had a balanopreputial HPV infection in 70%, anal in 30%, and urethral in 37%, while HIV negative patients had balanopreputial lesion in 72%, anal in 26%, and urethral in 16%. DiVuse anogenital lesions were present in 33% of the HIV infected cases and in 10.5% of HIV negative cases (p<0.02). Among the HIV infected patients, the genital HPV lesions were condylomatous in 67.5% of the cases and dysplastic in 57%. HIV negative patients had condylomatous lesions in 86% of the cases and dysplasic in 14%. The condylomatous lesions of HIV infected patients had a low grade malignant histological aspect in 36% of the cases and high grade histological criteria were found in 22% of the dysplasias. Oncogenic HPVs were detected more frequently in HIV infected patients (35% v 12%) and more than one HPV type was found in 21.5% of cases. Neither the anogenital diVusion of the HPV lesions nor their morphological, histological, and virological features diVered significantly in patient with CD4 cell counts > or < 200 × 10 6 /l. In contrast, patients with CD4 cell counts < 50 × 10 6 /l had a higher risk of several types of HPVs and of developing a diVuse anogenital infection. Conclusion: HIV-1 infected patients had an increased frequency of high grade anogenital dysplastic lesions and a higher frequency of HPV infection with multiple and diVuse sites of involvement. These characteristics of HPV infection were independent of the patients' immune status up to CD4 cell counts > 50 × 10 6 /l but showed an increased risk when the CD4 cell count was < 50 × 10 6 /l. The higher frequency of diVuse anogenital infections among HIV infected men calls for rapid treatment, laser or surgery, given the association of histological features of intraepithelial neoplasia and the presence of multiple HPV infection sites which may be the consequence of immune disturbances, most of which are transmissible potentially oncogenic HPVs. (Sex Transm Inf 1998;74:32-34)

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Section: Histological Examinationmentioning

confidence: 99%

Comparison of clinical, histological, and virological symptoms of HPV in HIV-1 infected men and immunocompetent subjects

Aynaud¹,

Piron²,

Barrasso³

et al. 1998

Sexually Transmitted Infections

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“…The association between condyloma acuminata caused by HPV types 16, 18, 31, and 33 and the development of squamous-cell carcinoma of the uterine cervix is established now beyond doubt. 67,68 Lesions of the cervix designated currently ''low grade squamous intraepithelial lesion (mild dysplasia/CIN I)'' and that show hyperchromatic nuclei in the lower third of surface epithelium but that do not show cytopathologic attributes of infection by HPV, in reality, are very superficial squamous-cell carcinomas and should be diagnosed as that. Those lesions are analogous morphologically to the solar keratotic type of very superficial squamous-cell carcinoma (solar keratosis) of the skin.…”

Section: Resultsmentioning

confidence: 99%

Nomenclature for Very Superficial Squamous Cell Carcinoma of the Skin and of the Cervix: A Critique in Historical Perspective

Kessler

Ackerman²

2006

The American Journal of Dermatopathology

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Squamous-cell carcinoma is the most common of all cancers and it develops in diverse organs of the body, among those being the skin, lung, gastrointestinal tract, and genitourinary tract, the latter including the cervix. Unfortunately, no unanimity exists for naming very superficial squamous-cell carcinoma; it has not been designated in consistent fashion in a single organ, let alone in all of them, thereby resulting in confusion, not only in regard to terminology per se, but concerning matters conceptual, not the least of those being what appellation to apply to that condition when it is encountered histopathologically. This vexing situation is illustrated graphically in the skin by diagnoses for very superficial squamous-cell carcinoma as disparate as solar keratosis (actinic keratosis, senile keratosis), arsenical keratosis, radiation keratosis, Bowen disease, bowenoid papulosis, squamous-cell carcinoma in situ, as well as variations on the theme of "keratinocytic intraepidermal neoplasia" and "dysplasia," and in the cervix by squamous-cell carcinoma in situ, leukoplakia, cervical intraepithelial neoplasia I-III, as well as variations on the theme of "squamous dysplasia ()." What follows now is a recounting of the history of the subject under consideration here, a critique of dizzying, opaque terms and phrases given to that subject, and a proposal for rectifying what currently is a thoroughly untenable situation because the language, and the ideas expressed by it, are impenetrable to physicians and, thereby, are decidedly disadvantageous to patients. There is a need urgently for a single term for very superficial squamous-cell carcinoma in every organ of the body in which it develops, to wit, one that conveys diagnosis in such logical, lucid, comprehensible fashion that it is understandable, readily and immediately, to clinicians. In that way, physicians charged with management of patients can plan therapy rationally.

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“…The adoption of this two-tier classification over the previous three-or four-tier systems was based largely on the desire to increase uniformity in reporting and to reduce the pervasive interobserver variability in cytologic diagnoses. [42][43][44] This is of particular relevance because ploidy has been a good predictor of clinical behavior in both prospective and retrospective studies; the majority of CINs that progress or persist are aneuploid, whereas the majority of those that regress are diploid or polyploid. 18 Consensus is lacking when reporting cervical cancer precursor lesions identified in histologic sections.…”

Section: Terminologymentioning

confidence: 99%

Cervix

Felix¹,

Amezcua²

2009

Modern Surgical Pathology

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Correlative Study of Human Papillomavirus DNA, Histopathology, and Morphometry in Cervical Condyloma and Intraepithelial Neoplasia

Cited by 31 publications

References 0 publications

Comparison of clinical, histological, and virological symptoms of HPV in HIV-1 infected men and immunocompetent subjects

Comparison of clinical, histological, and virological symptoms of HPV in HIV-1 infected men and immunocompetent subjects

Nomenclature for Very Superficial Squamous Cell Carcinoma of the Skin and of the Cervix: A Critique in Historical Perspective

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