Correlative Study on Sex Differences in Pituitary Luteinizing Hormone Content and the Number of Immunoreactive Luteinizing Hormone Cells in Perinatal Rats

Watanabe, Yuichi

doi:10.1159/000242549

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…A sex difference was also evident, in that pituitaries of older females revealed more granules per cell and more immunoreactive cells than those of males of comparable ages, However, they did not observe the a-subunit alone as seen by several groups (Baker and Jaffe, 1975;Bugnon et al, 1977a;Dubois and Dubois, 1974;Dubois et al, 1978) by light microscopy immunohistochemistry or by radioimmunoassays (Hagen and McNeilly, 1975;Kaplan et al, 1976). In the rat, p-subunit of LH is detected at first (Tougard et al, 1977) but sex differences concerning gonadotrophs became pronounced during the first and fourth postnatal days (Watanabe, 1986).…”

Section: Ultrastructural Aspect Ofmentioning

confidence: 90%

Fetal development and regulation of pituitary cell types

Dubois

Hemming

1991

J. Elec. Microsc. Tech.

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The ontogenesis of the pituitary gland is considered from anatomical and functional points of view. Embryogenesis of the hypothalamo-pituitary unit involving development of the hypothalamo-hypophyseal portal system is complete during early life as shown in several mammalian species. The ultrastructural characteristics of the different cell types during development are described according to observations made by using immunochemical techniques. The patterns of differentiation of the cell types are reviewed according to studies of pituitary glands from human anencephalic fetuses and encephalectomized rat fetuses as well as in vitro studies of cultured pituitary primordia in synthetic media. The maturation of the neuroendocrine mechanisms controlling the secretion of fetal hormones is also analyzed. During fetal life, the factors implicated in the regulation of pituitary hormone secretion are generally the same as in adults, but the intensity of the response of pituitary cells to their action is variable according to the species, thus reflecting an immaturity in the functioning of certain cell types.

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Section: Ultrastructural Aspect Ofmentioning

confidence: 90%

Fetal development and regulation of pituitary cell types

Dubois

Hemming

1991

J. Elec. Microsc. Tech.

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An immunohistochemical study of adenohypophyseal cells containing follicle-stimulating hormone and luteinizing hormone during the phase of selective follicle-stimulating hormone release in postnatal female rats

et al. 1987

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Serum concentration of follicle-stimulating hormone (FSH) in the juvenile female rat increases independently from that of luteinizing hormone (LH). The objective of this study was to determine whether this increase in serum FSH is accompanied by a proliferation of FSH-cells greater than the proliferation of LH-cells. Thus, we measured circulating FSH and LH in female rats on days 3, 10, 13, 17, and 20, calculated the percentages of adenohypophyseal cells that contained FSH or LH on days 3, 10, and 20, and determined whether cells containing only FSH existed on day 10. Serum FSH concentrations on days 10 and 13 were significantly greater than those on days 3, 17, or 20. No differences existed in serum LH concentrations. Cells containing FSH or LH were distributed throughout the entire adenohypophyses of 3, 10, and 20-day-old females. Clusters of these cells were observed in the ventral regions of adenohypophyses of 3-day-old females. The percentages of adenohypophyseal cells containing FSH increased significantly from approximately 9% in 3-day-old rats to approximately 17% in 10-day-old rats and then decreased to approximately 14% in 20-day-old animals. At all ages the percentages of adenohypophyseal cells containing FSH were similar to the percentages of cells containing LH. At 10 days of age, all cells containing FSH also contained LH and all cells containing LH also contained FSH. These data suggest that the increase in serum FSH in the juvenile female rat is associated with an increase in the percentage of adenohypophyseal cells containing FSH and that at this time all cells containing FSH also contain LH.

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Sexual dimorphism of pituitary gonadotropes during postnatal development in the rat

Chen¹

1988

Molecular and Cellular Endocrinology

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Correlative Study on Sex Differences in Pituitary Luteinizing Hormone Content and the Number of Immunoreactive Luteinizing Hormone Cells in Perinatal Rats

Cited by 3 publications

References 28 publications

Fetal development and regulation of pituitary cell types

Fetal development and regulation of pituitary cell types

An immunohistochemical study of adenohypophyseal cells containing follicle-stimulating hormone and luteinizing hormone during the phase of selective follicle-stimulating hormone release in postnatal female rats

Sexual dimorphism of pituitary gonadotropes during postnatal development in the rat

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