Correspondence

Najeeb, Bilal Haj; Deák, Gábor; Gerendas, Bianca S.; Schmidt–Erfurth, U.

doi:10.1097/iae.0000000000003365

Cited by 1 publication

(2 citation statements)

References 12 publications

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“…However, the actual effect of SRF on visual function in MNV3 remains questionable, as Su et al [25] reported that SRF occurs eccentrically at the border of the PED and only in eyes with pronounced IRF. With respect to the quantitative and topographic changes of the IRF in relation to the progression of the lesion in the study of Sharma et al [12], there is ongoing debate about a better visual prognosis of the isolated IRF in type 3 eyes [11,12].…”

Section: Therapymentioning

confidence: 99%

“…The exact characterization of this type is important as recent multimodal imaging studies have shown that the frequency of MNV3 lesions in nAMD appears to be significantly higher than previously thought. Moreover, for this macular neovascularization (MNV) type, the validity of established optical coherence tomography (OCT) biomarkers such as intraretinal (IRF) and subretinal (SRF) fluid needs to be re-evaluated [8][9][10][11][12]. The current pathophysiological understanding of MNV3 and its implications for current patient care and future clinical research directions are described in detail.…”

Section: Introductionmentioning

confidence: 99%

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Current Perspectives on Type 3 Macular Neovascularization due to Age-Related Macular Degeneration

Clemens,

Eter,

Alten

2024

Ophthalmologica

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Background: The aim of this review was to systematically summarize the current knowledge on type 3 macular neovascularization (MNV3) in age-related macular degeneration (AMD). Summary: Recent histopathologic and multimodal imaging findings led to the consensus definition of the new term “type 3 macular neovascularization” in AMD. MNV3 originates in the deep vascular plexus as a neovascular process without connection with the retinal pigment epithelium in the initial stages. This type has numerous clinical and pathomorphologic features that separate it from the other two types of MNV in AMD. Besides, its frequency appears to be higher than previously thought. In optical coherence tomography (OCT), MNV3 can be classified into stages 1–3. Hyperreflective foci in the outer retina possibly represent a precursor lesion. In addition, MNV3 is characterized by a strong association with reticular pseudodrusen, a high rate of bilaterality, close associations with advanced age and arterial hypertension, decreased choroidal thickness, and decreased choriocapillaris flow signals. Data from latest anti-vascular endothelial growth factor studies in MNV3 suggest that the OCT biomarkers in intraretinal and subretinal fluids should be interpreted differently than in the other types. Additionally, data from MNV3 eyes should be analyzed separately, allowing optimal type-specific treatment strategies in the future. Key Messages: This review highlights the need for accurate characterization of neovascular AMD lesions and an MNV type-specific approach, particularly for MNV3.

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