Correspondence between bone mineral density and intervertebral disc degeneration across age and sex

Kaiser, Jarred; Allaire, Brett T.; Fein, Paul M.; Lu, Darlene; Jarraya, Mohamed; Guermazi, Ali; Demissie, Serkalem; Samelson, Elizabeth J.; Bouxsein, Mary L.; Morgan, Elise F.

doi:10.1007/s11657-018-0538-1

Cited by 30 publications

(33 citation statements)

References 46 publications

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“…IDD can have a large impact on the livelihood of patients and their economic development ( 1 ). IDD disrupts the distribution and density of the aged bone tissues in vertebrae ( 2 ). Nucleus pulposus (NP) mesenchymal stem cells (MSCs) can promote the regeneration of intervertebral discs due to their endogenous repair function ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Activation of SIRT1 promotes cartilage differentiation and reduces apoptosis of nucleus pulposus mesenchymal stem cells via the MCP1/CCR2 axis in subjects with intervertebral disc degeneration

Ying

Bai

et al. 2020

Int J Mol Med

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Intervertebral disc degeneration (Idd) is a condition involving disruption of the bone tissue distribution. Nucleus pulposus mesenchymal stem cells (NPMScs) and Sirtuin 1 (SIRT1) play important roles in bone diseases, therefore the aim of the present study was to evaluate the roles of SIRT1 and NPMScs in Idd. First, NPMScs were harvested from patients with Idd. Then, the NPMScs were treated with a SIRT activator, and monocyte chemoattractant protein 1 (McP1) and chemokine receptor 2 (ccR2) inhibitors. Indices related to NPMSc growth, proliferation, differentiation and apoptosis were measured. Subsequently, Idd rat models were established and were transfected with NPMScs overexpressing SIRT1. NPMSc apoptosis and cartilage differentiation were detected in the rat Idd model. SIRT1 expression was found to be decreased, and the expression of McP1 and ccR2 increased in NPMScs of patients with Idd. The upregulation of SIRT1 and the downregulation of the McP1/ccR2 axis promoted cartilage differentiation and reduced the number of apoptotic NPMScs. Furthermore, McP1 reversed the progression of the cartilage differentiation of NPMScs and the inhibition of NPMSc apoptosis induced by SIRT1 overexpression. Moreover, the transplantation of rat NPMScs overexpressing SIRT1 relieved Idd in rats. Therefore, SIRT1 overexpression improved cartilage differentiation and reduced the apoptosis of NPMScs by inactivating the McP1/ccR2 axis, thus attenuating Idd in rats.

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Section: Introductionmentioning

confidence: 99%

Activation of SIRT1 promotes cartilage differentiation and reduces apoptosis of nucleus pulposus mesenchymal stem cells via the MCP1/CCR2 axis in subjects with intervertebral disc degeneration

Ying

Bai

et al. 2020

Int J Mol Med

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“…Individuals with prevalent fractures generally present with lower integral and trabecular vBMD than controls, (9,38) a relationship that is anticipated given the relationship between declining vBMD (35,39,40) and increasing fracture rates with age. (41,42) In line with these findings, we observed that individuals with a prevalent fracture presented with approximately 20% lower integral (134 versus 165 mg/cm 3 ) and trabecular (96 versus 119 mg/cm 3 ) vBMD at the L 3 level (Table 1).…”

Section: Discussionmentioning

confidence: 91%

“…Additionally, although measures of areal BMD and trabecular bone score in this population would be beneficial to directly compare its association with prevalent fractures versus our QCT‐derived vBMD measures, DXA was not available within 1 year of the QCT scan for all participants in our study, making this direct comparison not possible for this manuscript. Our sample size was insufficient to adequately power subsequent delineation of the effect of sex, despite the known effects of sex on the age‐dependent decline of vBMD and fracture rates . Finally, the image processing steps in our approach are currently time consuming, limiting clinical utility at this time.…”

Section: Discussionmentioning

confidence: 99%

“…Regional values of volumetric BMD (rBMD) were calculated for 27 subregions of the trabecular centrum (three layers of nine subregions), and these subdivisions were combined to calculate the rBMD for each of the following regions: anterior, posterior, superior, mid‐transverse, inferior, central and outer (Fig. B ) . With the exception of the superior, mid‐transverse, and inferior regions, each region was continuous through the full height of the vertebra.…”

Section: Methodsmentioning

confidence: 99%

“…1B). (18,35) With the exception of the superior, mid-transverse, and inferior regions, each region was continuous through the full height of the vertebra. The four measures of spatial distribution in trabecular vBMD were then computed as the ratios of rBMD values (anterior/posterior, central/outer, superior/mid-transverse, and inferior/mid-transverse (Fig.…”

Section: Spatial Distribution In Trabecular Vbmdmentioning

confidence: 99%

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Heterogeneity and Spatial Distribution of Intravertebral Trabecular Bone Mineral Density in the Lumbar Spine Is Associated With Prevalent Vertebral Fracture

Kaiser

Allaire

Fein

et al. 2019

Journal of Bone and Mineral Research

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The spatial heterogeneity in trabecular bone density within the vertebral centrum is associated with vertebral strength and could explain why volumetric bone mineral density (vBMD) exhibits low sensitivity in identifying fracture risk. This study evaluated whether the heterogeneity and spatial distribution of trabecular vBMD are associated with prevalent vertebral fracture. We examined the volumetric quantitative computed tomography (QCT) scans of the L3 vertebra in 148 participants in the Framingham Heart Study Multidetector CT study. Of these individuals, 37 were identified as cases of prevalent fracture, and 111 were controls, matched on sex and age with three controls per case. vBMD was calculated within 5‐mm contiguous cubic regions of the centrum. Two measures of heterogeneity were calculated: (i) interquartile range (IQR); and (ii) quartile coefficient of variation (QCV). Ratios in the spatial distributions of the trabecular vBMD were also calculated: anterior/posterior, central/outer, superior/mid‐transverse, and inferior/mid‐transverse. Heterogeneity and spatial distributions were compared between cases and controls using Wilcoxon rank sum tests and t tests and tested for association with prevalent fractures with conditional logistic regressions independent of integral vBMD. Prevalent fracture cases had lower mean ± SD integral vBMD (134 ± 38 versus165 ± 42 mg/cm3, p < .001), higher QCV (0.22 ± 0.13 versus 0.17 ± 0.09, p = .003), and lower anterior/posterior rBMD (0.65 ± 0.13 versus 0.78 ± 0.16, p < .001) than controls. QCV was positively associated with increased odds of prevalent fracture (OR 1.61; 95% CI, 1.04 to 2.49; p = .034), but this association was not independent of integral vBMD (p = .598). Increased anterior/posterior trabecular vBMD ratio was associated with decreased odds of prevalent fracture independent of integral vBMD (OR 0.38; 95% CI, 0.20 to 0.71; p = .003). In conclusion, increased trabecular vBMD in the anterior versus posterior centrum, but not trabecular vBMD heterogeneity, was associated with decreased risk of prevalent fracture independent of integral vBMD. Regional measurements of trabecular vBMD could aid in determining the risk and underlying mechanisms of vertebral fracture. © 2019 American Society for Bone and Mineral Research.

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Changes in Vertebral Bone Density and Paraspinal Muscle Morphology Following Spaceflight and 1 Year Readaptation on Earth

Coulombe,

Johannesdottir,

Burkhart

et al. 2023

JBMR Plus

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Astronauts have an increased risk of back pain and disc herniation upon returning to Earth. Thus, it is imperative to understand the effects of spaceflight and readaptation to gravity on the musculoskeletal tissues of the spine. Here we investigated whether ~6 months of spaceflight led to regional differences in bone loss within the vertebral body. Additionally, we evaluated the relationships between vertebral bone density and paraspinal muscle morphology before flight, after flight, and after readaptation on Earth. We measured vertebral trabecular bone mineral density (Tb.BMD), paraspinal muscle cross‐sectional area (CSA), and muscle density in 17 astronauts using computed tomography (CT) images of the lumbar spine obtained before flight (before flight, n = 17), after flight (spaceflight, n = 17), and ~12 months of readaptation to gravitational loading on Earth (follow‐up, n = 15). Spaceflight‐induced declines in Tb.BMD were greater in the superior region of the vertebral body (−6.7%) than the inferior (−3.1%, p = 0.052 versus superior region) and transverse regions (−4.3%, p = 0.057 versus superior region). After a year of readaptation to Earth's gravity, Tb.BMD in the transverse region remained significantly below preflight levels (−4.66%, p = 0.0094). Paraspinal muscle CSA and muscle density declined −1.0% (p = 0.005) and −0.83% (p = 0.001) per month of spaceflight, respectively. Ultimately, bone loss in the superior vertebral body, along with fatty infiltration of paraspinal muscles and incomplete recovery even after a year of readaptation on Earth, may contribute to spinal pathology in long‐duration astronauts. © 2023 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.

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Correspondence between bone mineral density and intervertebral disc degeneration across age and sex

Cited by 30 publications

References 46 publications

Activation of SIRT1 promotes cartilage differentiation and reduces apoptosis of nucleus pulposus mesenchymal stem cells via the MCP1/CCR2 axis in subjects with intervertebral disc degeneration

Activation of SIRT1 promotes cartilage differentiation and reduces apoptosis of nucleus pulposus mesenchymal stem cells via the MCP1/CCR2 axis in subjects with intervertebral disc degeneration

Heterogeneity and Spatial Distribution of Intravertebral Trabecular Bone Mineral Density in the Lumbar Spine Is Associated With Prevalent Vertebral Fracture

Changes in Vertebral Bone Density and Paraspinal Muscle Morphology Following Spaceflight and 1 Year Readaptation on Earth

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