Correspondence of Pubertal Neuroendocrine and Tanner Stage Changes in Boys and Associations With Substance Use

Marceau, Kristine; Kirisci, Levent; Tarter, Ralph E.

doi:10.1111/cdev.13101

Cited by 16 publications

(7 citation statements)

References 46 publications

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“…Specifically, in those with low pT exposure, pubertal testosterone increased or “masculinized” lateralization while it decreased or “de-masculinized” lateralization in those with high pT. While Beking and colleagues measured pubertal testosterone rather than pubertal timing (although they are likely correlated; Marceau et al, 2019 ; Shirtcliff et al, 2009 ), both our findings and those of Beking et al support the idea that the effects of pT may interact with pubertal factors to influence sexually differentiated traits. Peper et al (2009) found that putative effects of pT due to having a male twin in utero were seen in brain volumes in children aged 9 but not in adults, suggesting that the effect of pT on brain volume does not persist beyond adolescence.…”

Section: Discussionsupporting

confidence: 72%

Is there an association between prenatal testosterone and autistic traits in adolescents?

Dooley

Ruigrok

Holt

et al. 2022

Psychoneuroendocrinology

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Prenatal testosterone (pT) is a crucial component in physiological masculinization in humans. In line with the Prenatal Sex Steroid Theory of autism, some studies have found a positive correlation between pT and autistic traits in childhood. However, effects in adolescence have not been explored. Hormonal and environmental changes occurring during puberty may alter the strength or the nature of prenatal effects on autistic traits. The current study examines if pT relates to autistic traits in a non-clinical sample of adolescents and young adults ( N = 97, 170 observations; age 13–21 years old). It also explores pT interactions with pubertal stage and timing. PT concentrations were measured from amniotic fluid extracted in the 2nd trimester of gestation via amniocentesis conducted for clinical purposes. Autistic traits were measured by self- and parent-reports on the Autism Spectrum Quotient (AQ) which provides a total score and 5 sub-scores (social skills, communication, imagination, attention switching and attention to detail). Self-reported pubertal stage was regressed on age to provide a measure of relative timing. We found no statistical evidence for a direct association between pT and autistic traits in this adolescent sample (males, females or full sample). Exploratory analyses suggested that pT correlated positively with autistic traits in adolescents with earlier puberty-onset, but statistical robustness of this finding was limited. Further exploratory post-hoc tests suggested the pT-by-pubertal timing interaction was stronger in males relative to females, in self-reported compared to parent-reported AQ and specifically for social traits. These findings require replication in larger samples. Findings have implications for understanding the effects of pT on human behavior, specifically existence of effects in adolescence.

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Section: Discussionsupporting

confidence: 72%

Is there an association between prenatal testosterone and autistic traits in adolescents?

Dooley

Ruigrok

Holt

et al. 2022

Psychoneuroendocrinology

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“…For maturational stage, Tanner’s self-evaluation method of pubertal maturation was used [ 26 ], which consists of choosing the stage that best suited each child, based on one of the images on a card that ranged from grade one to five (1 = pre-puberty; 2–4 = puberty; 5 = post-puberty). This is a non-invasive, reliable, and valid indicator of biological maturation [ 27 , 28 ].…”

Section: Methodsmentioning

confidence: 99%

Physical Activity Practice and Optimal Development of Postural Control in School Children: Are They Related?

García-Soidán

García-Liñeira

Leirós‐Rodríguez

et al. 2020

JCM

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Background: This study aims to analyze the effect of physical activity practice on the postural control state of school children. If such an effect was detected, the second aim of the study was to identify which specific capacities of postural control benefited the most from physical activity. Methods: A cross-sectional study was performed using a convenience sample of 118 healthy children (54 girls) with a mean age of 10.3 ± 1.2 years. Their weight and height were measured. The accelerometric assessment of balance included four different tests in static balance and walking. Results: Physical activity habit prevalence was 38.9% in girls and 60.9% in boys, and its frequency was 2.3 days per week in girls and 2.8 days in boys. The active children obtained lower accelerations, but the active and sedentary girls showed lower accelerometric values than the active boys. The logistic regression analysis demonstrated the influence of sex on the accelerations of the body (p < 0.001), regardless of the habit of physical activity. Conclusions: Active children have better postural control than sedentary children, although sedentary girls have better balance than active boys. Therefore, physical activity practice seems to favor a more efficient development of postural control, but it cannot level or reverse the effect of the neurophysiological factors that are conditioned by sex.

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“…One particular robust finding, relevant to the adolescent treatment context, is that pubertal maturation, particularly increased testosterone, promotes structural and functional development of the striatum (Braams et al., ; Goddings et al., ; Herting et al., ; Op De Macks et al., ). This is salient, as hormonally mediated striatal development has been implicated as predictive of risk taking and substance use during adolescence (Braams et al., ; Marceau et al., ), above and beyond chronological age. This suggests that variability in gonadal hormones may play a crucial role in organizing striatal development and consequential reward‐seeking behavior during adolescence, factors relevant in the adolescent addiction treatment context.…”

Section: The Nature Of the Adolescent Brain: Characteristic Features mentioning

confidence: 99%

Hunting for What Works: Adolescents in Addiction Treatment

Silvers

Squeglia

Thomsen³

et al. 2019

Alcoholism Clin & Exp Res

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Although adolescents are developmentally distinct from adults, they often receive addiction treatment based on adult models. This is problematic because adolescents face significantly different conditions in addiction treatment, including distinct basic biological and neurodevelopmental stages, unique sociodevelopmental concerns, distinctive addiction trajectories, and, in turn, disparate treatment goals and outcomes. In sum, it can be difficult for even savvy clinicians to know how to approach addiction treatment with this important age group. In an effort to help clinicians and researchers consider substance use via a neurodevelopmental lens, we approached this review with 4 goals: (i) characterize the prevalence, and related health and safety implications of substance use within this age group; (ii) identify the nature of the adolescent brain, including characteristic features of this phase of neurodevelopment relevant to adolescent substance use treatment; (iii) provide an overview of current adolescent addiction interventions and avenues to improve clinical treatment and clinical research efforts for adolescents; and (iv) examine the intersection between the nature of the developing brain and adolescent substance use, and utilize that information to inform alternative routes and directions for substance use treatment in this critical age group. This review concludes by offering a novel neurodevelopmental model and framework to examine substance use interventions, along with a series of recommendations to optimize adolescent substance use treatment and clinical research.

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Correspondence of Pubertal Neuroendocrine and Tanner Stage Changes in Boys and Associations With Substance Use

Cited by 16 publications

References 46 publications

Is there an association between prenatal testosterone and autistic traits in adolescents?

Is there an association between prenatal testosterone and autistic traits in adolescents?

Physical Activity Practice and Optimal Development of Postural Control in School Children: Are They Related?

Hunting for What Works: Adolescents in Addiction Treatment

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