Corrigenda: Hybrid surgery–radiosurgery therapy for metastatic epidural spinal cord compression: A prospective evaluation using patient-reported outcomes

Barzilai, Ori; Amato, Mary-Kate; McLaughlin, Lily; Reiner, Anne S.; Ogilvie, Shahiba Q.; Lis, Eric; Yamada, Yoshiya; Bilsky, Mark H.; Laufer, Ilya

doi:10.1093/nop/npx024

Cited by 1 publication

(2 citation statements)

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“…Spine SRS delivers high doses of radiation accurately to tumors and spares adjacent healthy tissues, such as the spinal cord and nerve roots, and lastly improves pain and neurological symptoms caused by spinal cord compression in patients with spinal metastases [23] . HT has achieved good results in the treatment of spinal metastatic tumor with the advantages of durable local control, effective palliation of pain, and improvement of neurological symptoms while minimizing operative morbidity [23][24][25] . The results of this study showed that the operative time and blood loss in the HT group were signi cantly less than that in the TES group, but the same local control, pain improvement, and overall survival could be achieved.…”

Section: Discussionmentioning

confidence: 99%

“…Firstly, separation surgery provides circumferential decompression of the spinal cord, and then, SRS is added to decrease local recurrence. Studies have shown that the local control rate of HT could reach up to 90% [24] . However, such studies were highly heterogeneous, and the current results did not truly re ect the treatment effect for solitary high-grade ESCC spinal metastases.…”

Section: Introductionmentioning

confidence: 99%

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Hybrid therapy versus Total En Bloc Spondyectomy in the treatment of Solitary Radioresistant Spinal Metastases：A propensity score-matched analysis

Zheng

Shi

et al. 2021

Preprint

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Background Both hybrid therapy (HT) and total en bloc spondylectomy (TES)can lead to good results for solitary radioresistant metastatic spinal tumors with high-grade epidural spinal cord compression (ESCC). However, there is still a lack of comparative studies on the treatment efficacy of these two methods. Methods We retrospectively reviewed patients with the above-mentioned tumors between January 2012 and May 2019. A total of 157 patients underwent surgery, among whom 64 received HT, and 93 were treated with TES. Propensity score matching allowed the generation of best-matched pairs for the 2 categories (1:1 ratio). Local control rates and survival rates were estimated using the Kaplan–Meier method. Results All patients received a minimum of 2-year follow-up. The longest follow-up time was 88 months. The survival rates and local progression-free survival rates after HT were comparable with TES at 1 year (84.6% vs. 83.1%; 90.2% vs. 90%), 2 year (60.8% vs. 64.3%; 64.1% vs. 62.1%), and 5 year (18.8% vs. 24.1%; 24.4% vs. 28.4%). There were no significant differences in pain control, improvement of neurological status, spine stabilization restoration, and improvement in quality of life between groups. However, HT showed more advantages in shortening operative time and reducing intraoperative blood loss than TES. Conclusion Our results suggest that HT can obtain satisfactory results comparable to TES for solitary radioresistant metastatic spinal tumors with high-grade ESCC. In addition, compared with TES, HT has the advantages of shortening operative time and reducing perioperative complications. For solitary radioresistant metastatic spinal tumors with a high degree of ESCC, HT may be a promising treatment in the future.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%