Corrigendum: Considerations for Studying Sex as a Biological Variable in Spinal Cord Injury

Stewart, Andrew N.; MacLean, Steven M.; Stromberg, Arnold J.; Whelan, Jessica P.; Bailey, William M.; Gensel, John C.; Wilson, Melinda E.

doi:10.3389/fneur.2020.597689

Cited by 5 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While the prevalence of SCI is higher among males, the incidence of SCI in females is increasing ( 10 ). Sex appears to be a significant factor affecting outcomes following SCI, but its extent remains unclear because the inclusion of females in clinical studies is often underpowered and the vast majority of animal studies use a single sex ( 11 , 12 ). However, some indications of sexual dimorphism have emerged; improved outcomes have been observed for females 1-year post-SCI using American Spinal Injury Association (ASIA) metrics ( 13 ).…”

Section: Introductionmentioning

confidence: 99%

Sexual Dimorphism in Lesion Size and Sensorimotor Responses Following Spinal Cord Injury

et al. 2022

View full text Add to dashboard Cite

Spinal cord injury (SCI) is a devastating disorder, which impacts the lives of millions of people worldwide with no clinically standardized treatment. Both pro-recovery and anti-recovery factors contribute to the overall outcome after the initial SCI. Sex is emerging as an important variable, which can affect recovery post-SCI. Contusion SCI at T10 was generated in male and female rats. Open-field Basso, Beattie, Bresnahan (BBB) behavioral test, Von Frey test, and CatWalk gate analysis were performed. Histological analysis was performed at the 45-day post-SCI end point. Male/female differences in sensorimotor function recovery, lesion size, and the recruitment of immune cells to the lesion area were measured. A group of males with less severe injuries was included to compare the outcomes for severity. Our results show that both sexes with the same injury level plateaued at a similar final score for locomotor function. Males in the less severe injury group recovered faster and plateaued at a higher BBB score compared to the more severe injury group. Von Frey tests show faster recovery of sensory function in females compared to both male groups. All three groups exhibited reduced mechanical response thresholds after SCI. The lesion area was significantly larger in the male group with severe injury than in females, as well as in males of less severe injury. No significant differences in immune cell recruitment were identified when comparing the three groups. The faster sensorimotor recovery and significantly smaller lesion area in females potentially indicate that neuroprotection against the secondary injury is a likely reason for sex-dependent differences in functional outcomes after SCI.

show abstract

Section: Introductionmentioning

confidence: 99%

Sexual Dimorphism in Lesion Size and Sensorimotor Responses Following Spinal Cord Injury

et al. 2022

View full text Add to dashboard Cite

show abstract

“…A GR of 0.25 was used as a threshold based on the epidemiological occurrence of 0.25 for female:male in the United States for SCI. 4 A GR greater than 0.25 suggests increased gender diversity. Because of unreported data, only 53 trials were included in our analysis on race.…”

mentioning

confidence: 99%

Letter: Charting a Path Forward: Factors Influencing Gender and Racial Disparities in Spinal Cord Injury Trials

et al. 2023

View full text Add to dashboard Cite

Sex-specific alterations in functional connectivity and network topology in patients with degenerative cervical myelopathy

Oughourlian,

Rizvi,

Wang

et al. 2024

Sci Rep

View full text Add to dashboard Cite

Patients with degenerative cervical myelopathy (DCM) experience structural and functional brain reorganization. However, few studies have investigated the influence of sex on cerebral alterations. The present study investigates the role of sex on brain functional connectivity (FC) and global network topology in DCM and healthy controls (HCs). The resting-state functional MRI data was acquired for 100 patients (58 males vs. 42 females). ROI-to-ROI FC and network topological features were characterized for each patient and HC. Group differences in FC and network topological features were examined. Compared to healthy counterparts, DCM males exhibited higher FC between vision-related brain regions, and cerebellum, brainstem, and thalamus, but lower FC between the intracalcarine cortex and frontal and somatosensory cortices, while DCM females demonstrated higher FC between the thalamus and cerebellar and sensorimotor regions, but lower FC between sensorimotor and visual regions. DCM males displayed higher FC within the cerebellum and between the posterior cingulate cortex (PCC) and vision-related regions, while DCM females displayed higher FC between frontal regions and the PCC, cerebellum, and visual regions. Additionally, DCM males displayed significantly greater intra-network connectivity and efficiency compared to healthy counterparts. Results from the present study imply sex-specific supraspinal functional alterations occur in patients with DCM.

show abstract

Corrigendum: Considerations for Studying Sex as a Biological Variable in Spinal Cord Injury

Cited by 5 publications

References 0 publications

Sexual Dimorphism in Lesion Size and Sensorimotor Responses Following Spinal Cord Injury

Sexual Dimorphism in Lesion Size and Sensorimotor Responses Following Spinal Cord Injury

Letter: Charting a Path Forward: Factors Influencing Gender and Racial Disparities in Spinal Cord Injury Trials

Sex-specific alterations in functional connectivity and network topology in patients with degenerative cervical myelopathy

Contact Info

Product

Resources

About