Corrigendum: Diversity of resistant determinants, virulence factors, and mobile genetic elements in Acinetobacter baumannii from India: A comprehensive in silico genome analysis

Kumkar, Shital N.; Kamble, Ekta E.; Chavan, Nikeeta S.; Dhotre, Dhiraj; Pardesi, Karishma

doi:10.3389/fcimb.2022.1130394

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar to our observations, high prevalence of sul2 and tetB among A. baumannii has been reported in previous studies from India [32, 45], Pakistan [46] and Algeria [47]. Besides conferring resistance to tetracycline and doxycycline, the tetB gene mediates resistance to minocycline, a widely employed drug for CRAB infections with the ability to overcome most of the resistance mechanisms affecting other tetracyclines including tigecycline [48].…”

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

Genotyping of Acinetobacter baumannii isolates from a tertiary care hospital in Cochin, South India

Rajan,

Vijayan,

Puthiyottu Methal

et al. 2023

Access Microbiology

View full text Add to dashboard Cite

Acinetobacter baumannii poses a significant challenge in healthcare settings across the globe, with isolates exhibiting carbapenem resistance at unprecedented rates. Here, we characterized a collection of A. baumannii isolates (n=64) recovered during the period September 2020 – November 2021 at a teaching hospital in Cochin, South India. The species identity of the isolates was confirmed with bla OXA-51-like PCR. The major carbapenemase determinants identified were bla OXA-23-like (45, 70.3 %) and bla NDM-1 (31, 48.4 %); co-occurrence of these genes was also observed in 27 (42.2 %) isolates. Other resistance genes identified included bla PER (34, 53.1 %), aac(6')-Ib-cr (42, 65.6 %), qnrS (25, 39.1 %), sul1 (32, 50 %), sul2 (33, 51.6 %), strA/strB (36, 56.3 %), aphA1-Iab (35, 54.7 %) and tetB (32, 50 %). Mapping PCR revealed the insertion element, ISAbaI upstream of bla OXA-23-like in all isolates possessing this gene. Concerning disinfectant resistance, all isolates carried the quaternary ammonium compound (QAC) resistance gene, qacEΔ1. Minimal inhibitory concentration (MIC) of benzalkonium chloride was high among the isolates and ranged from 8 to 128 µg ml−1. However, low MICs were observed for chlorhexidine and triclosan, with the majority (54, 80.6 %) of isolates showing an MIC of 2 µg ml−1 for chlorhexidine and all isolates exhibiting MICs of ≤0.125 µg ml−1 for triclosan. Further, all isolates were strong biofilm-producers, as assessed by the crystal violet-based microtitre plate assay. The ApaI-pulsed-field gel electrophoresis (PFGE) revealed the multi-clonal nature of the isolates, with 16 clusters and 16 unique pulsotypes identified at a cut-off of 80 %. In short, this study provides useful data on the molecular features of A. baumannii from this region, which could be helpful to assess the local epidemiology of this pathogen and also to devise infection control strategies.

show abstract

Section: Discussionsupporting

confidence: 90%

“…A recent whole genome-based study on A. baumannii isolates ( n =47) from India revealed the presence of as many as 79 types of ARGs of intrinsic and acquired nature [45]. Similar to our observations, high prevalence of sul2 and tetB among A.…”

Section: Discussionsupporting

confidence: 90%

Genotyping of Acinetobacter baumannii isolates from a tertiary care hospital in Cochin, South India

Rajan,

Vijayan,

Puthiyottu Methal

et al. 2023

Access Microbiology

View full text Add to dashboard Cite

show abstract

Corrigendum: Diversity of resistant determinants, virulence factors, and mobile genetic elements in Acinetobacter baumannii from India: A comprehensive in silico genome analysis

Abstract: In the published article, there was an error in the Funding statement. We did not acknowledge the Director, NCCS, Pune for providing financial support for article processing charges. The correct Funding statement appears below.

Cited by 1 publication

References 0 publications

Genotyping of Acinetobacter baumannii isolates from a tertiary care hospital in Cochin, South India

Genotyping of Acinetobacter baumannii isolates from a tertiary care hospital in Cochin, South India

Contact Info

Product

Resources

About