Corrigendum: Evaluation of Glymphatic System Using Diffusion MR Technique in T2DM Cases

Yang, Guangwei; Deng, Nan; Liu, Yi; Gu, Yingjiang; Yao, Xiang

doi:10.3389/fnhum.2020.616400

Front. Hum. Neurosci.

2021

DOI: 10.3389/fnhum.2020.616400

|View full text |Cite

Corrigendum: Evaluation of Glymphatic System Using Diffusion MR Technique in T2DM Cases

Guangwei Yang

Nan Deng²,

Yi Liu

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The glymphatic system is a highly organized fluid-clearance pathway 1,2 involving the movement of cerebrospinal fluid (CSF) alongside the perivascular space. 3 This glymphatic system allows the clearance of extracellular proteins such as amyloid β and tau, while deletion of the AQP4 gene suppresses this clearance capability. The glymphatic system has been visualized in vivo using two-photon imaging with a fluorescent tracer and laser-scanning microscope.…”

mentioning

confidence: 99%

Gray matter reserve determines glymphatic system function in young‐onset Alzheimer's disease: Evidenced by DTI‐ALPS and compared with age‐matched controls

Chang

Huang

Hsu

et al. 2023

Psychiatry Clin Neurosci

View full text Add to dashboard Cite

Background The diffusion tensor imaging analysis along the perivascular space (ALPS)‐index can be used to model the glymphatic system in vivo. Aim This study explores putative mechanisms between prediction of ALPS‐index and cognitive outcomes in young‐onset Alzheimer's disease (YOAD) and age‐matched controls (CTLs) and analyzes whether the link was mediated by the integrity of ALPS‐index‐anchored cerebral gray matter (GM). Methods We enrolled 130 patients with YOAD and 137 CTLs. All participants underwent three‐dimensional T1‐weighted MRI, diffusion tensor imaging and cognitive tests. We constructed GM regions correlated with the ALPS‐index in the YOAD and CTL groups. For the GM regions significantly correlated with the ALPS‐index and cognitive measures, we extracted a 4‐mm radius sphere. In the YOAD and CTL groups, we used mediator analysis to explore the ALPS‐index as predictor, GM partitions as mediators, and significant cognitive test scores as outcomes. Results Patient group had significantly lower ALPS‐index. The ALPS‐index was associated with GM volume in the cerebellar gray, dorsolateral prefrontal, thalamus, superior frontal, amygdala and hippocampus, and these coherent regions coincided with those showing GM atrophy in the YOAD group. Mediation analysis of the YOAD group suggested that the relationships between the ALPS‐index and cognitive performance were fully mediated by the integrity of ALPS‐index coherent GM areas. Discussion Reserved GM mediates the link between the glymphatic system and cognition. Our findings suggest that GM integrity rather than the glymphatic system could serve as a direct cognitive test scores predictor in patients with YOAD.

show abstract

mentioning

confidence: 99%

Gray matter reserve determines glymphatic system function in young‐onset Alzheimer's disease: Evidenced by DTI‐ALPS and compared with age‐matched controls

Chang

Huang

Hsu

et al. 2023

Psychiatry Clin Neurosci

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Corrigendum: Evaluation of Glymphatic System Using Diffusion MR Technique in T2DM Cases

Cited by 1 publication

References 1 publication

Gray matter reserve determines glymphatic system function in young‐onset Alzheimer's disease: Evidenced by DTI‐ALPS and compared with age‐matched controls

Gray matter reserve determines glymphatic system function in young‐onset Alzheimer's disease: Evidenced by DTI‐ALPS and compared with age‐matched controls

Contact Info

Product

Resources

About