Corrigendum: Reductive Power Generated by Mycobacterium leprae Through Cholesterol Oxidation Contributes to Lipid and ATP Synthesis

Rosa, Thabatta Leal Silveira Andrezo; Marques, Maria Angela M.; DeBoard, Zachary; Hutchins, Kelly; Silva, Carlos Adriano A.; Montague, Christine R; Yuan, Tianao; Amaral, Julio Jablonski; Atella, Geórgia C.; Rosa, Patrícia Sammarco; Mattos, Katherine Antunes de; VanderVen, Brian C.; Lahiri, Ramanuj; Sampson, Nicole S.; Brennan, Patrick J.; Belisle, John T.; Pessolani, Maria Cristina Vidal; Berrêdo-Pinho, Márcia

doi:10.3389/fcimb.2021.765326

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many molecules, metabolic and functional steps are common to pathologies involving chronic inflammation. So, the identification of common mechanisms may indicate points that could be targeted for development of new diagnostic and therapeutic tools ( Lobato et al, 2014 ; Rosa et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Modulation of the Response to Mycobacterium leprae and Pathogenesis of Leprosy

Cabral

Figueiredo²,

Gandini³

et al. 2022

Front. Microbiol.

View full text Add to dashboard Cite

The initial infection by the obligate intracellular bacillus Mycobacterium leprae evolves to leprosy in a small subset of the infected individuals. Transmission is believed to occur mainly by exposure to bacilli present in aerosols expelled by infected individuals with high bacillary load. Mycobacterium leprae-specific DNA has been detected in the blood of asymptomatic household contacts of leprosy patients years before active disease onset, suggesting that, following infection, the bacterium reaches the lymphatic drainage and the blood of at least some individuals. The lower temperature and availability of protected microenvironments may provide the initial conditions for the survival of the bacillus in the airways and skin. A subset of skin-resident macrophages and the Schwann cells of peripheral nerves, two M. leprae permissive cells, may protect M. leprae from effector cells in the initial phase of the infection. The interaction of M. leprae with these cells induces metabolic changes, including the formation of lipid droplets, that are associated with macrophage M2 phenotype and the production of mediators that facilitate the differentiation of specific T cells for M. leprae-expressed antigens to a memory regulatory phenotype. Here, we discuss the possible initials steps of M. leprae infection that may lead to active disease onset, mainly focusing on events prior to the manifestation of the established clinical forms of leprosy. We hypothesize that the progressive differentiation of T cells to the Tregs phenotype inhibits effector function against the bacillus, allowing an increase in the bacillary load and evolution of the infection to active disease. Epigenetic and metabolic mechanisms described in other chronic inflammatory diseases are evaluated for potential application to the understanding of leprosy pathogenesis. A potential role for post-exposure prophylaxis of leprosy in reducing M. leprae-induced anti-inflammatory mediators and, in consequence, Treg/T effector ratios is proposed.

show abstract

Section: Discussionmentioning

confidence: 99%

Modulation of the Response to Mycobacterium leprae and Pathogenesis of Leprosy

Cabral

Figueiredo²,

Gandini³

et al. 2022

Front. Microbiol.

View full text Add to dashboard Cite

show abstract

Prediction of the risk of recurrence of the leprosy process

Genatullina,

Yasenyavskaya,

Tsibizova

et al. 2024

jour

View full text Add to dashboard Cite

The aim of the study was to study the degree of neutrophil granulocyte myeloperoxidase activity in peripheral blood of patients with leprosy in order to predict the possible recurrence of the infectious process.Materials and methods. Electron grams of biopsies of the affected skin and blood smears of 8 (5 women and 3 men) patients with borderline (BB), 9 (6 women and 3 men) patients with subpolar lepromatous (LLs) and 7 (4 women and 3 men) patients with polar lepromatous (LLr) were used as the object of the study forms of leprosy. At the ultramicroscopic level, the degree of MP activity detected by the electron-cytochemical method in the Mf of biopsies of the affected skin, both first registered before the start of therapy and with the activation of the process during treatment, was taken into account. The percentage of mitochondria with MP Mf activity relative to the MP of inactive cells was calculated. In peripheral blood smears, the activity of neutrophilic granulocytes (NG) MP was evaluated by the mean cytochemical coefficient (SCC).Results. It was found that in patients with the highest percentage of peroxidase-active mitochondria (79-92%), the presence of MP activity on the membranes of phagosomes and in the electron-transparent zone (around M. leprae) correlated with rapid and persistent regression of the leprosy process and long periods of relapse-free period, which was determined by comparing the data of medical histories with the results obtained in during our research. It was found that in patients without relapse with forms of BB and LLs leprosy, the activity of MP in neutrophils was 1.3 times higher (p<0.05), and the percentage of peroxidase-active mitochondria was 3 times higher (p<0.01) compared with these indicators of patients with relapse of the disease. When comparing the studied markers of groups of patients without relapse with the form of leprosy LLp, the degree of MP NG activity increased by 1.4 times (p<0.05), the percentage of mitochondria with MP Mf activity increased by 3 times (p<0.01) relative to patients with relapses.Conclusion. Thus, the determination of myeloperoxidase activity of neutrophil granulocytes of peripheral blood can act as a prognostic marker for determining the effectiveness of anti-leprosy therapy and the risk of relapses of the disease during and after treatment.

show abstract

Corrigendum: Reductive Power Generated by Mycobacterium leprae Through Cholesterol Oxidation Contributes to Lipid and ATP Synthesis

Cited by 2 publications

References 0 publications

Modulation of the Response to Mycobacterium leprae and Pathogenesis of Leprosy

Modulation of the Response to Mycobacterium leprae and Pathogenesis of Leprosy

Prediction of the risk of recurrence of the leprosy process

Contact Info

Product

Resources

About