Corrigendum: The Emerging Role of Rho Guanine Nucleotide Exchange Factors in Cardiovascular Disorders: Insights Into Atherosclerosis: A Mini Review

Li, Mengqi; Jiao, Qingzheng; Xin, Wenqiang; Niu, Shulin; Liu, Mingming; Song, Yanxin; Wang, Zengguang; Yang, Xinyu; Liang, Degang

doi:10.3389/fcvm.2022.850258

Cited by 2 publications

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“…A key finding based on analysis of protein interactions in this network is that PDIA3 interactome ( Figure 6 ) plays a key role in atherosclerosis. For example, interactions of PDIA3 with AKT1 ( 126 ) and interactions of AKT1with TIAM1 regulate the expression of the multicellular protein osteopontin ( 127 , 128 ), which is involved in generating the atheromatous pathology of atherosclerosis ( 129 ). Furthermore, interactions of PDIA3 with brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2; a.k.a.…”

Section: Resultsmentioning

confidence: 99%

Effects of vitamin D signaling in cardiovascular disease: centrality of macrophage polarization

Fliri,

Kajiji

2024

Front. Cardiovasc. Med.

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Among the leading causes of natural death are cardiovascular diseases, cancer, and respiratory diseases. Factors causing illness include genetic predisposition, aging, stress, chronic inflammation, environmental factors, declining autophagy, and endocrine abnormalities including insufficient vitamin D levels. Inconclusive clinical outcomes of vitamin D supplements in cardiovascular diseases demonstrate the need to identify cause-effect relationships without bias. We employed a spectral clustering methodology capable of analyzing large diverse datasets for examining the role of vitamin D's genomic and non-genomic signaling in disease in this study. The results of this investigation showed the following: (1) vitamin D regulates multiple reciprocal feedback loops including p53, macrophage autophagy, nitric oxide, and redox-signaling; (2) these regulatory schemes are involved in over 2,000 diseases. Furthermore, the balance between genomic and non-genomic signaling by vitamin D affects autophagy regulation of macrophage polarization in tissue homeostasis. These findings provide a deeper understanding of how interactions between genomic and non-genomic signaling affect vitamin D pharmacology and offer opportunities for increasing the efficacy of vitamin D-centered treatment of cardiovascular disease and healthy lifespans.

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Section: Resultsmentioning

confidence: 99%

Effects of vitamin D signaling in cardiovascular disease: centrality of macrophage polarization

Fliri,

Kajiji

2024

Front. Cardiovasc. Med.

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show abstract

“…A key finding based on analysis of protein interactions in this network is that PDIA3 interactome (Figure 6) plays a key role in atherosclerosis. For example, interactions of PDIA3 with AKT1 (126) and interactions of AKT1with TIAM1 regulate the expression of the multicellular protein osteopontin (127, 128), which is involved in generating the atheromatous pathology of atherosclerosis (129). Furthermore, interactions of PDIA3 with brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2; a.k.a.…”

Section: Vitamin D Non-genomic Signalingmentioning

confidence: 99%

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Corrigendum: The Emerging Role of Rho Guanine Nucleotide Exchange Factors in Cardiovascular Disorders: Insights Into Atherosclerosis: A Mini Review

Cited by 2 publications

References 0 publications

Effects of vitamin D signaling in cardiovascular disease: centrality of macrophage polarization

Effects of vitamin D signaling in cardiovascular disease: centrality of macrophage polarization

Table1.xlsx

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