Corrigendum to “A dual inhibitor of matrix metalloproteinases and a disintegrin and metalloproteinases, [18F]FB-ML5, as a molecular probe for non-invasive MMP/ADAM-targeted imaging” [Bioorg. Med. Chem. 23 (2014) 192–202]

Matusiak, Nathalie; Castelli, Riccardo; Tuin, Adriaan W.; Overkleeft, Herman S.; Wisastra, Rosalina; Dekker, Frank J.; Prely, Laurette M.; Bischoff, Rainer; Waarde, Aren van; Dierckx, Rudi; Elsinga, Philip H.

doi:10.1016/j.bmc.2015.02.025

Cited by 1 publication

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These characteristics are of less importance for the labelling of small molecules, as these generally are more stable and selectivity is not a big issue because a protective group strategy can be applied easily. For the labelling of small molecules, [ 18 84,93,[322][323][324][325][326][327][328][329][330][331][332][333][334][335][336] The main reason is the fact that at various PET imaging centres, the method to synthesise [ 18 F]SFB is readily available and automated for its use in the labelling of peptides. From a practical point of view, it is thus a small step to also use [ 18 F]SFB for the labelling of small molecules.…”

Section: -[ 18 F]mentioning

confidence: 99%

“…The [327][328][329] This method is however not recommended, as it only results in longer synthesis times and lower radiochemical yields, without having any advantages over the onepot procedure.…”

Section: -[ 18 F]mentioning

confidence: 99%

“…As a building block for the synthesis of low molecular weight PET tracers, [ 18 F]SFB is used solely in the base catalysed acylation of primary amine precursors, as shown in Scheme 117. 84,93,[322][323][324][325][326][327][328][329][331][332][333][334][335][336] The main advantages of labelling amine precursors with [ 18 (Table 2). As a consequence, the precursors are easier to synthesise and no removal of the protecting groups is necessary afterwards.…”

Section: -[ 18 F]mentioning

confidence: 99%

“…These conditions are used when the precursor is highly water soluble. 93,323,325,[327][328][329]331,335 (2) Reactions in organic solvents (DMSO, DMF, MeCN), using bases which readily dissolve in these solvents (DIPEA, NEt 3 ). These conditions are used when the precursor is insoluble in water.…”

Section: -[ 18 F]mentioning

confidence: 99%

“…a Includes removal of acetyl protecting groups. 84,93,[322][323][324][325][326][327][328][329][331][332][333][334][335][336] , which can be easily introduced in peptides (Scheme 123). 340 The radiochemical yields towards the mixtures of endo and exo bicyclic isoxazolidines 540a-c, as measured by HPLC, were 87% for 540a, 91% for 540b and 91% for 540c.…”

Section: Synthesis and Application Of 6-mentioning

confidence: 99%

See 4 more Smart Citations

Fluorine-18 labelled building blocks for PET tracer synthesis

et al. 2017

View full text Add to dashboard Cite

Positron emission tomography (PET) is an important driver for present day healthcare. Fluorine-18 is the most widely used radioisotope for PET imaging and a thorough overview of the available radiochemistry methodology is a prerequisite for selection of a synthetic approach for new fluorine-18 labelled PET tracers. These PET tracers can be synthesised either by late-stage radiofluorination, introducing fluorine-18 in the last step of the synthesis, or by a building block approach (also called modular build-up approach), introducing fluorine-18 in a fast and efficient manner in a building block, which is reacted further in one or multiple reaction steps to form the PET tracer. This review presents a comprehensive overview of the synthesis and application of fluorine-18 labelled building blocks since 2010.

show abstract