Corrigendum to ‘Balasubramide derivative 3C modulates microglia activation via CaMKKβ-dependent AMPK/PGC-1α pathway in neuroinflammatory conditions’ [Brain Behav. Immun. 67 (2018) 101–117]

Ruan, Wenchen; Mi, Junru; Xu, Jingfen; Wang, Haojie; Cao, Zhengyu; Saavedra, Juan M.; Zhang, Luyong; Lin, Hansen; Pang, Tao

doi:10.1016/j.bbi.2019.12.015

Cited by 2 publications

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“…The compound 3C , which is a derivative of Balasubramide , is an e ight-member lactam compound that has been isolated from Clausena lansium. Skeels, Multiple studies have demonstrated that the administration of balasubramide Derivative 3C leads to a significant upregulation of AMPK and its upstream target calmodulin-dependent protein kinase β (CaMKKβ), thereby activating the M2 polarization of microglia ( WANG et al, 2018a ). This activation subsequently results in a reduction in the release of proinflammatory factors such as TNF-α, IL-1β, IL-6, iNOS, and COX-2.…”

Section: The Mechanism Of Tcmhs Intervention In Microglia and Its Rel...mentioning

confidence: 99%

“…This activation subsequently results in a reduction in the release of proinflammatory factors such as TNF-α, IL-1β, IL-6, iNOS, and COX-2. Consequently, in a rat model of tMCAO, the infarct area was reduced, while in BV2 cells, the production of proinflammatory cytokines induced by LPS was improved and the administration of balasubramide Derivative 3C promoted sensorimotor recovery and inhibited the infiltration of inflammatory cells ( WANG et al, 2018a ; WANG et al, 2018b ). Sinomenine (SION) , an alkaloid was found to inhibit the inflammatory body NLRP3 through the regulation of the AMPK signaling pathway in both the MCAO mouse model and OGD mixed glial cell model, It downregulated the expression of IL-1β, IL-6, IL-18, and TNF-α, and mitigated the excessive activation of microglia following cerebral ischemic injury, which shown in Figure 2 ( QIU et al, 2016 ).…”

Section: The Mechanism Of Tcmhs Intervention In Microglia and Its Rel...mentioning

confidence: 99%

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Exploring Chinese herbal medicine for ischemic stroke: insights into microglia and signaling pathways

Zhang,

Xu,

et al. 2024

Front. Pharmacol.

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Ischemic stroke is a prevalent clinical condition affecting the central nervous system, characterized by a high mortality and disability rate. Its incidence is progressively rising, particularly among younger individuals, posing a significant threat to human well-being. The activation and polarization of microglia, leading to pro-inflammatory and anti-inflammatory responses, are widely recognized as pivotal factors in the pathogenesis of cerebral ischemia and reperfusion injury. Traditional Chinese herbal medicines (TCHMs) boasts a rich historical background, notable efficacy, and minimal adverse effects. It exerts its effects by modulating microglia activation and polarization, suppressing inflammatory responses, and ameliorating nerve injury through the mediation of microglia and various associated pathways (such as NF-κB signaling pathway, Toll-like signaling pathway, Notch signaling pathway, AMPK signaling pathway, MAPK signaling pathway, among others). Consequently, this article focuses on microglia as a therapeutic target, reviewing relevant pathway of literature on TCHMs to mitigate neuroinflammation and mediate IS injury, while also exploring research on drug delivery of TCHMs. The ultimate goal is to provide new insights that can contribute to the clinical management of IS using TCHMs.

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Section: The Mechanism Of Tcmhs Intervention In Microglia and Its Rel...mentioning

confidence: 99%

Section: The Mechanism Of Tcmhs Intervention In Microglia and Its Rel...mentioning

confidence: 99%

Exploring Chinese herbal medicine for ischemic stroke: insights into microglia and signaling pathways

Zhang,

Xu,

et al. 2024

Front. Pharmacol.

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“…[9,10] DNase I, which cleaves single-and double-stranded DNA, is often used to degrade NETs to suppress immunopathology, [11] but it cannot inhibit the NET generation at the source. Moreover, promoting anti-inflammatory activation of microglia, the brain's innate immune cells, [12][13][14] is an effective way to treat ischemic stroke, [13,15] however, the feasibility of delivering targeted drugs to microglia in the central nervous system (CNS) remains elusive.…”

Section: Introductionmentioning

confidence: 99%

A Neutrophil Hijacking Nanoplatform Reprograming NETosis for Targeted Microglia Polarizing Mediated Ischemic Stroke Treatment

Yin,

Wang,

Pei

et al. 2024

Advanced Science

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Precise and efficient regulation of microglia is vital for ischemic stroke therapy and prognosis. The infiltration of neutrophils into the brain provides opportunities for regulatory drugs across the blood–brain barrier, while hindered by neutrophil extracellular traps (NETs) and targeted delivery of intracerebral drugs to microglia. This study reports an efficient neutrophil hijacking nanoplatform (referred to as APTS) for targeted A151 (a telomerase repeat sequence) delivery to microglia without the generation of NETs. In the middle cerebral artery occlusion (MCAO) mouse model, the delivery efficiency to ischemic stroke tissues increases by fourfold. APTS dramatically reduces the formation of NETs by 2.2‐fold via reprogramming NETosis to apoptosis in neutrophils via a reactive oxygen species scavenging‐mediated citrullinated histone 3 inhibition pathway. Noteworthy, A151 within neutrophils is repackaged into apoptotic bodies following the death pattern reprogramming, which, when engulfed by microglia, polarizes microglia to an anti‐inflammatory M2 phenotype. After four times treatment, the cerebral infarction area in the APTS group decreases by 5.1‐fold. Thus, APTS provides a feasible, efficient, and practical drug delivery approach for reshaping the immune microenvironment and treating brain disorders in the central nervous system.

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Corrigendum to ‘Balasubramide derivative 3C modulates microglia activation via CaMKKβ-dependent AMPK/PGC-1α pathway in neuroinflammatory conditions’ [Brain Behav. Immun. 67 (2018) 101–117]

Cited by 2 publications

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Exploring Chinese herbal medicine for ischemic stroke: insights into microglia and signaling pathways

Exploring Chinese herbal medicine for ischemic stroke: insights into microglia and signaling pathways

A Neutrophil Hijacking Nanoplatform Reprograming NETosis for Targeted Microglia Polarizing Mediated Ischemic Stroke Treatment

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