Corrigendum to “Biological effects of imidazolium ionic liquids with varying chain lengths in acute Vibrio fischeri and WST-1 cell viability assays” [Ecotoxicol. Environ. Safety 58 (2004) 396–404]

Ranke, Johannes; Mölter, Kerstin; Stock, Frauke; Bottin‐Weber, Ulrike; Poczobutt, Joanna M.; Hoffmann, J. A.; Ondruschka, Bernd; Filser, Juliane; Jastorff, Bernd

doi:10.1016/j.ecoenv.2004.09.004

Cited by 83 publications

(157 citation statements)

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“…The toxicity of ILs has been investigated and a number of ILs have been proven to be biocompatible [12,13]. It was shown that the addition of some hydrophilic alkylammonium-based ILs did not significantly reduce the lysozyme activity compared to pure aqueous solutions [14].…”

Section: Introductionmentioning

confidence: 99%

Crystalline Proteins as an Alternative to Standard Formulations

2008

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Crystalline proteins may offer superior properties for drug delivery compared to standard protein formulations such as aqueous solutions or amorphous precipitated lyophilisates. In this study, a new approach using biocompatible, hydrophilic, substituted alkylammonium-based ionic liquids (ILs) as additives for the advanced crystallization of two exemplary proteins, lysozyme and lipase, was investigated. Sitting-drop vapor diffusion crystallization experiments revealed that the addition of some of the ILs resulted in less crystal polymorphism and precipitation was consistently avoided, even at larger concentrations of the conventional crystallization agent. The kinetics of lysozyme crystallization were significantly enhanced by a factor of up to 5.5 using ILs with strongly hydrated anions, i.e., formate or glycolate. In contrast, ILs with weakly hydrated anions, i.e., nitrate, led to undesirable spontaneous precipitation. In addition, lipase was crystallized preferentially using an IL with a strongly hydrated anion, i.e. dihydrogenphosphate. Large, sturdy crystals were formed at rates which were enhanced by a factor of up to 4.

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Section: Introductionmentioning

confidence: 99%

Crystalline Proteins as an Alternative to Standard Formulations

2008

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“…Although the negligible volatility of ILs is one appealing point in the use of ILs in place of volatile organic solvents, the finite solubility of ILs in water has raised concern in wastewater treatments and other circumstances. [169][170][171][172][173][174][175][176][177][178][179][180][181][182][183][184][185][186][187] Since ILs are salts having certain solubility in water, the interface between an IL and water is inevitably electrified. There are a number of systems in which the phase-boundary potential across the IL|W interface plays a crucial role in determining the physicochemical characteristics of the systems.…”

Section: Introductionmentioning

confidence: 99%

Mutual Solubility of Hydrophobic Ionic Liquids and Water in Liquid-Liquid Two-phase Systems for Analytical Chemistry

Kakiuchi

2008

ANAL. SCI.

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Liquid-liquid two-phase systems formed by a hydrophobic ionic liquid and water find several useful ways of application in analytical chemistry. One of the most important properties of such two-phase systems is the mutual solubility of the IL and water. Recent advancements on this subject have been reviewed. The solubility of ionic liquids in water is related to the standard Gibbs energies of the transfer of ions constituting the ionic liquid from the ionic liquid phase to water. Although this single ionic property cannot be measured thermodynamically and also varies from one ionic liquid to another, the standard Gibbs energy of the ion transfer from a polar aprotic solvent, such as nitrobenzene and 1,2-dichloroethane, to water is a convenient measure for it. The solubility of an ionic liquid in water and the electrochemical properties at the interface between the two phases are intimately related with each other.

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“…(2) 1-alkyl chain [21]. Though the reason why this difference of cytotoxicity of the ILs to the cell occurred is not clarified, it might be caused by the cell type and the solubilized condition of the ILs.…”

Section: Resultsmentioning

confidence: 99%