Corrigendum to “Chitosan/silk fibroin modified nanofibrous patches with mesenchymal stem cells prevent heart remodeling post-myocardial infarction in rats” [Acta Biomater. 80 (2018) 154–168]

Chen, Jiangwei; Zhan, Yingfei; Wang, Yabin; Han, Dongyi; Tao, Bo; Luo, Zhenli; Ma, Sai; Wang, Qun; Li, Xiang; Fan, Li; Li, Congye; Deng, Hongbing; Cao, Feng

doi:10.1016/j.actbio.2019.03.035

Cited by 17 publications

(23 citation statements)

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“…The MSCs-laden chitosan/silk fibroin modified nanofibrous patches lead to higher cell viability, less ventricular remodeling, enhanced left ventricular function, attenuated cardiac fibrosis and apoptosis, and promoted neovascularization [ 113] A gelatin-PCL nanofiber scaffold with flexible, freestanding electronics Electrospinning Ventricular cardiomyocytes of neonatal SD rat / Enable integration of cardiac cells, controllable release of biological factors, recording of cellular electrical activities and the electrical stimulation for synchronizing cell contraction [ 114] Polycaprolactone (PCL) Melt electrowriting Human iPSC-CMs, Porcine Enhance the beating rate, alignment, and maturation of hiPSC-CMs in vitro; allow further maturation of contractile myocytes after in vivo application on porcine heart without negative effects [ 115] CNT-incorporated methacrylated collagen (MeCol) and alginate Reproduced with permission. [109] Copyright 2018, American Association for the Advancement of Science (AAAS).…”

Section: Electrospinning Mouse Adipose Derived Mscsmentioning

confidence: 99%

Cardiomyocyte Induction and Regeneration for Myocardial Infarction Treatment: Cell Sources and Administration Strategies

Chen

2020

Adv Healthcare Materials

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Occlusion of coronary artery and subsequent damage or death of myocardium can lead to myocardial infarction (MI) and even heart failure-one of the leading causes of deaths world wide. Notably, myocardium has extremely limited regeneration potential due to the loss or death of cardiomyocytes (i.e., the cells of which the myocardium is comprised) upon MI. A variety of stem cells and stem cell-derived cardiovascular cells, in situ cardiac fibroblasts and endogenous proliferative epicardium, have been exploited to provide renewable cellular sources to treat injured myocardium. Also, different strategies, including direct injection of cell suspensions, bioactive molecules, or cell-incorporated biomaterials, and implantation of artificial cardiac scaffolds (e.g., cell sheets and cardiac patches), have been developed to deliver renewable cells and/or bioactive molecules to the MI site for the myocardium regeneration. This article briefly surveys cell sources and delivery strategies, along with biomaterials and their processing techniques, developed for MI treatment. Key issues and challenges, as well as recommendations for future research, are also discussed.

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Section: Electrospinning Mouse Adipose Derived Mscsmentioning

confidence: 99%

Cardiomyocyte Induction and Regeneration for Myocardial Infarction Treatment: Cell Sources and Administration Strategies

Chen

2020

Adv Healthcare Materials

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“…The fabrications of ideal hydrogel scaffolds could con rm the optimistic cellular activity to support cell proliferations, which is greatly favorable as a stem cell carrier. Additionally, the loading of nanomaterials into the hydrogel have been induce electric transmission, inter and intra-cellular communications and particularly metabolic activity at micro-environment of myocardial infarcted site [21][22][23]. In addition, the improving mechanical properties and micro-environment of hydrogel matrix provides favorable inhibitions ability against ventricular remodeling in MI [24,25].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the improving mechanical properties and micro-environment of hydrogel matrix provides favorable inhibitions ability against ventricular remodeling in MI [24,25]. Silk protein is a widely available natural bio-polymer derived from silk cocoons that has unique biological and mechanical abilities, which provides effective actions in regenerative medicine, drug delivery, bio-adhesives, etc., [3,6,23]. The biocompatibility, mechanical stability, biodegradability properties of silk protein hydrogels can be modulate for the required microenvironmental conditions [3,23].…”

Section: Introductionmentioning

confidence: 99%

“…Silk protein is a widely available natural bio-polymer derived from silk cocoons that has unique biological and mechanical abilities, which provides effective actions in regenerative medicine, drug delivery, bio-adhesives, etc., [3,6,23]. The biocompatibility, mechanical stability, biodegradability properties of silk protein hydrogels can be modulate for the required microenvironmental conditions [3,23]. Speci cally, the cardiovascular disease therapies and myocardial regenerations are greatly depended on the electrical conductivity of the implanted materials for cellular functions co-ordinations and signal transductions of electroactive tissues [5,26].…”

Section: Introductionmentioning

confidence: 99%

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Development and novel design of clustery Graphene Oxide formed Conductive Silk hydrogel cell vesicle to Repair Myocardial Infarction: Investigation of its biological activity for cell delivery applications

Duan²,

Guo

2020

Preprint

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Cell delivery therapy is a talented and hopeful strategic approach to repair the damaged cardiac tissues after myocardial infarction. The biocompatible injectable hydrogel with bioactive nanomaterials with effective self-healing capability has been highly required for the cell delivery and regeneration therapy. In the present study, we have developed the biopolymeric and biocompatible self-healing silk protein hydrogel matrix with graphene oxide nanoformulations as cell delivery vehicles for the treatment of myocardial infarction regeneration. The materials combinations, structural interactions, thermal stability and morphology of the designed hydrogel were investigated and elaborated. To improve therapeutic potential of the hydrogel matrix, growth factor was loaded and investigated its biological activity such as cell survival and cell proliferations properties by using endothelial progenitor cells. Collected, these developed materials are excellent vesicle for cell therapy in myocardial infarction.

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“…Scaffolds derived from Bombyx mori silk fibroin (referred to as “silk” throughout) have been used to engineer a number of tissues including heart, bone, cartilage, arteriovenous grafts, esophagous, nerve, urethra, and liver . Silk‐based biomaterials show great promise in regenerative medicine applications, but rapid vascularization of large, 3D silk constructs remains challenging.…”

Section: Introductionmentioning

confidence: 99%

Vascular Pedicle and Microchannels: Simple Methods Toward Effective In Vivo Vascularization of 3D Scaffolds

Rnjak‐Kovacina

Gerrand

Wray

et al. 2019

Adv Healthcare Materials

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Poor vascularization remains a key limiting factor in translating advances in tissue engineering to clinical applications. Vascular pedicles (large arteries and veins) isolated in plastic chambers are known to sprout an extensive capillary network. This study examined the effect vascular pedicles and scaffold architecture have on vascularization and tissue integration of implanted silk scaffolds. Porous silk scaffolds with or without microchannels are manufactured to support implantation of a central vascular pedicle, without a chamber, implanted in the groin of Sprague Dawley rats, and assessed morphologically and morphometrically at 2 and 6 weeks. At both time points, blood vessels, connective tissue, and an inflammatory response infiltrate all scaffold pores externally, and centrally when a vascular pedicle is implanted. At week 2, vascular pedicles significantly increase the degree of scaffold tissue infiltration, and both the pedicle and the scaffold microchannels significantly increase vascular volume and vascular density. Interestingly, microchannels contribute to increased scaffold vascularity without affecting overall tissue infiltration, suggesting a direct effect of biomaterial architecture on vascularization. The inclusion of pedicles and microchannels are simple and effective proangiogenic techniques for engineering thick tissue constructs as both increase the speed of construct vascularization in the early weeks post in vivo implantation.

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Corrigendum to “Chitosan/silk fibroin modified nanofibrous patches with mesenchymal stem cells prevent heart remodeling post-myocardial infarction in rats” [Acta Biomater. 80 (2018) 154–168]

Cited by 17 publications

References 0 publications

Cardiomyocyte Induction and Regeneration for Myocardial Infarction Treatment: Cell Sources and Administration Strategies

Cardiomyocyte Induction and Regeneration for Myocardial Infarction Treatment: Cell Sources and Administration Strategies

Development and novel design of clustery Graphene Oxide formed Conductive Silk hydrogel cell vesicle to Repair Myocardial Infarction: Investigation of its biological activity for cell delivery applications

Vascular Pedicle and Microchannels: Simple Methods Toward Effective In Vivo Vascularization of 3D Scaffolds

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