Corrigendum to “EF24 Suppresses Invasion and Migration of Hepatocellular Carcinoma Cells <i>In Vitro</i> via Inhibiting the Phosphorylation of Src”

Zhao, Ruihua; Tin, Lamtin; Zhang, Yuhua; Wu, Yiqi; Jin, Yinji; Jin, Xiaoming; Zhang, Fengmin; Li, Xiaobo

doi:10.1155/2021/9839618

Cited by 3 publications

(9 citation statements)

References 1 publication

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“…EF-24 possesses numerous pharmacological properties, such as anti-oxidant, anti-inflammatory, and anti-cancer effects. [12][13][14][15][16][17][18]52 The suppression of reactive oxygen species generation was shown in the effect of EF-24 on ovarian carcinoma cells. 17 Selvendiran et al, desmonstrated that EF-24 induces apoptosis and G2/M arrest in human ovarian cancer cells through the activation of PTEN.…”

Section: Discussionmentioning

confidence: 99%

“…18 In additional, recent studies have shown that EF-24 exerts anti-migration ability in various cancers. 23,52,53 For example, EF-24 significantly inhibited migration and reduced the invasion of cholangiocarcinoma cell by regulating cytoskeletal structure and focal adhesion formation. 23 Therapeutic role of EF-24 in ovarian cancer cells was revealed to targeting GT1-mediated metabolism and cell migration ability.…”

Section: Discussionmentioning

confidence: 99%

“…Anticancer effects of EF‐24 were also investigated in HCT‐116 colon cancer xenografts 18 . In additional, recent studies have shown that EF‐24 exerts anti‐migration ability in various cancers 23,52,53 . For example, EF‐24 significantly inhibited migration and reduced the invasion of cholangiocarcinoma cell by regulating cytoskeletal structure and focal adhesion formation 23 .…”

Section: Discussionmentioning

confidence: 99%

“…EF‐24 possesses numerous pharmacological properties, such as anti‐oxidant, anti‐inflammatory, and anti‐cancer effects 12–18,52 . The suppression of reactive oxygen species generation was shown in the effect of EF‐24 on ovarian carcinoma cells 17 .…”

Section: Discussionmentioning

confidence: 99%

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EF‐24 inhibits TPA‐induced cellular migration and MMP‐9 expression through the p38 signaling pathway in cervical cancer cells

Lee

Lin

et al. 2022

Environmental Toxicology

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Diphenyl difluoroketone (EF-24), a synthetic curcumin analog, has enhanced bioavailability over curcumin. EF-24 acts more powerful bioactivity for anti-inflammatory and anti-cancer activity. However, the effects and mechanism of EF-24 on cervical cancer has not been fully investigated. Herein, this study evaluated the effects of EF-24 on TPA-induced cellular migration of cervical cancer. The results showed that EF-24 substantially reduced the cellular migration and cellular invasion of the HeLa and SiHa cells. Moreover, gelatin zymography, western blotting analyses and real-time PCR revealed that EF-24 suppressed Matrix metalloproteinase-9 (MMP-9) activity, protein expression and mRNA levels. Mechanistically, EF-24 inhibited the phosphorylation of the p38 signaling pathway. In conclusion, EF-24 inhibited TPA-induced cellular migration and cellular invasion of cervical cancer cell lines through modulating MMP-9 expression via downregulating signaling p38 pathway and EF-24 may have potential to serve as a chemopreventive agent of cervical cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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EF‐24 inhibits TPA‐induced cellular migration and MMP‐9 expression through the p38 signaling pathway in cervical cancer cells

Lee

Lin

et al. 2022

Environmental Toxicology

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“…Its elevated expression level is associated with poor prognostic outcomes [93,94]. Src is highly expressed in LC cells and tumors, and its targeting can repress anoikis resistance, metastasis, treatment resistance, growth, stemness, invasion, tumorigenesis, migration, and mobility [95][96][97][98][99][100][101].…”

Section: Discussionmentioning

confidence: 99%

Investigation of Anti-Liver Cancer Activity of the Herbal Drug FDY003 Using Network Pharmacology

Lee

Park³

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Globally, liver cancer (LC) is the sixth-most frequently occurring and the second-most fatal malignancy, responsible for 0.83 million deaths annually. Although the application of herbal drugs in cancer therapies has increased, their anti-LC activity and relevant mechanisms have not been fully studied from a systems perspective. To address these issues, we conducted a system-perspective network pharmacological investigation into the activity and mechanisms underlying the action of the herbal drug. FDY003 reduced the viability of human LC treatment. FDY003 reduced the viability of human LC cells and elevated their chemosensitivity. There were a total of 16 potential bioactive chemical components in FDY003 and they had 91 corresponding targets responsible for the pathological processes in LC. These FDY003 targets were functionally involved in regulating the survival, proliferation, apoptosis, and cell cycle of LC cells. Additionally, we found that FDY003 may target key signaling cascades connected to diverse LC pathological mechanisms, namely, PI3K-Akt, focal adhesion, IL-17, FoxO, MAPK, and TNF pathways. Overall, this study contributed to integrative mechanistic insights into the anti-LC potential of FDY003.

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Anticarcinogenic Potency of EF24: An Overview of Its Pharmacokinetics, Efficacy, Mechanism of Action, and Nanoformulation for Drug Delivery

Sazdova,

Keremidarska-Markova,

Dimitrova

et al. 2023

Cancers

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EF24, a synthetic monocarbonyl analog of curcumin, shows significant potential as an anticancer agent with both chemopreventive and chemotherapeutic properties. It exhibits rapid absorption, extensive tissue distribution, and efficient metabolism, ensuring optimal bioavailability and sustained exposure of the target tissues. The ability of EF24 to penetrate biological barriers and accumulate at tumor sites makes it advantageous for effective cancer treatment. Studies have demonstrated EF24’s remarkable efficacy against various cancers, including breast, lung, prostate, colon, and pancreatic cancer. The unique mechanism of action of EF24 involves modulation of the nuclear factor-kappa B (NF-κB) and nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways, disrupting cancer-promoting inflammation and oxidative stress. EF24 inhibits tumor growth by inducing cell cycle arrest and apoptosis, mainly through inhibiting the NF-κB pathway and by regulating key genes by modulating microRNA (miRNA) expression or the proteasomal pathway. In summary, EF24 is a promising anticancer compound with a unique mechanism of action that makes it effective against various cancers. Its ability to enhance the effects of conventional therapies, coupled with improvements in drug delivery systems, could make it a valuable asset in cancer treatment. However, addressing its solubility and stability challenges will be crucial for its successful clinical application.

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Corrigendum to “EF24 Suppresses Invasion and Migration of Hepatocellular Carcinoma Cells In Vitro via Inhibiting the Phosphorylation of Src”

Cited by 3 publications

References 1 publication

EF‐24 inhibits TPA‐induced cellular migration and MMP‐9 expression through the p38 signaling pathway in cervical cancer cells

EF‐24 inhibits TPA‐induced cellular migration and MMP‐9 expression through the p38 signaling pathway in cervical cancer cells

Investigation of Anti-Liver Cancer Activity of the Herbal Drug FDY003 Using Network Pharmacology

Anticarcinogenic Potency of EF24: An Overview of Its Pharmacokinetics, Efficacy, Mechanism of Action, and Nanoformulation for Drug Delivery

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