Corrigendum to “Endothelial dysfunction mediated by interleukin-18 in patients with ischemic heart disease undergoing coronary artery bypass grafting surgery” [Med. Hypotheses 104 (2017) 20–24]

Sokolić, J; Tokmadžić, Vlatka Sotošek; Knežević, Danijel; Medved, Igor; Damjani, N. Vukelic; Balen, Sanja; Rakić, Marijana; Bastiančić, Ana Lanča; Laškarin, Gordana

doi:10.1016/j.mehy.2017.12.023

Cited by 1 publication

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“…In patients with MI who undergo coronary artery bypass grafting (CABG), elevated levels of IL-18 in the systemic circulation have been reported to activate lymphocytes, which may subsequently lead to EC cytotoxicity [ 99 ]. I/R injury triggers the activation of the NLRP3/IL-18 signaling pathway, which in turn induces the transcription of CXCL16 in cardiac vascular endothelial cells (VECs).…”

Section: Endothelial Cells (Ecs)mentioning

confidence: 99%

“…For instance, IL-18 reduces the severity of viral myocarditis by inducing the cardiac expression of IFN-γ mRNA and increasing the activity of natural killer cells in the spleen [ 115 ]. In addition, in MI patients undergoing coronary artery bypass grafting (CABG), IL-18 in systemic circulation leads to the activation of lymphocyte cytotoxicity, then enhancing circulating lymphocyte activity [ 99 ].…”

Section: Immune Cellsmentioning

confidence: 99%

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Pathophysiological Effects of Various Interleukins on Primary Cell Types in Common Heart Disease

Liu

Zhang

Yin

2023

IJMS

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Myocardial infarction (MI), heart failure, cardiomyopathy, myocarditis, and myocardial ischemia-reperfusion injury (I/R) are the most common heart diseases, yet there is currently no effective therapy due to their complex pathogenesis. Cardiomyocytes (CMs), fibroblasts (FBs), endothelial cells (ECs), and immune cells are the primary cell types involved in heart disorders, and, thus, targeting a specific cell type for the treatment of heart disease may be more effective. The same interleukin may have various effects on different kinds of cell types in heart disease, yet the exact role of interleukins and their pathophysiological pathways on primary cell types remain largely unexplored. This review will focus on the pathophysiological effects of various interleukins including the IL-1 family (IL-1, IL-18, IL-33, IL-37), IL-2, IL-4, the IL-6 family (IL-6 and IL-11), IL-8, IL-10, IL-17 on primary cell types in common heart disease, which may contribute to the more precise and effective treatment of heart disease.

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Section: Endothelial Cells (Ecs)mentioning

confidence: 99%

Section: Immune Cellsmentioning

confidence: 99%