Corrigendum to “Ginsenoside Rd contributes the attenuation of cardiac hypertrophy in vivo and in vitro” [Biomed. Pharmacother. 109 (2019) 1016–1023]

Zhang, Ningning; An, Xiangbo; Lang, Ping-Ping; Wang, Feng; Xie, Yuanfang

doi:10.1016/j.biopha.2020.110720

Cited by 2 publications

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“…MicroRNAs (miRNAs), non‐coding endogenous single strand RNAs with an average 22 nucleotides in length, [8–10] are one of the major gene expressions regulating agents [11,12] . Any changes in intracellular amounts of miRNA lead to severe diseases, abnormalities, and cancers such as breast, glioblastoma, liver, ovary, prostate, lung, gastric, colon, and endocrine pancreatic tumors.…”

Section: Introductionmentioning

confidence: 99%

Graphene Quantum Dot‐PEI‐Cyclodextrin Nanocarrier for Simultaneous miR21a Delivery and Cell Imaging in Cancer Therapy

et al. 2023

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Over‐expression of miR21 plays an important role in several cancers by promoting cancer cell proliferation, migration, invasion, and metastasis. Here, we attempted to prepare a beta cyclodextrin‐polyethyleneimine‐graphene quantum dot (βCD‐PEI‐GQD) nanocarrier for cellular delivery of miR21a. For this purpose, tosylated‐βCD and GQD were conjugated to branched PEI. The product was characterized by FTIR, 1H‐NMR, and fluorescence spectroscopy. The morphology, particle size distribution, and ζ‐potential of miR21a were examined by TEM and DLS following overnight incubation with βCD‐PEI‐GQD in aqueous media. The miR21 silencing was measured by stem‐loop RT‐PCR in HepG2 human hepatoma cell line. Cellular uptake and cell toxicity assays were determined by fluorescence microscopy and Trypan blue staining method, respectively. The formation of miR21a/CD‐PEI‐GQD Nanoplex with a decreased average size of 114 nm and a ζ‐potential (+36.1 mV) lower than CD‐PEI‐GQD nanocarrier by adding miR21a was confirmed at optimum C/P ratio =8.7. RT‐PCR revealed that miR21a/βCD‐PEI‐GQD Nanoplex significantly downregulated miR21 expression levels effectively. Overall, miR21a delivery using CD‐PEI‐GQD is presented as a novel trackable nanocarrier for cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Graphene Quantum Dot‐PEI‐Cyclodextrin Nanocarrier for Simultaneous miR21a Delivery and Cell Imaging in Cancer Therapy

et al. 2023

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Cardioprotective Effects and Mechanisms of Saponins on Cardiovascular Disease

Lü

et al. 2022

Natural Product Communications

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Cardiovascular disease (CVD), a leading cause of morbidity and mortality, is among the most prevalent health problems worldwide and effective strategies for its prevention and treatment are urgently required. In this regard, increasing research has demonstrated that natural drugs offer antihypertensive, antiatherosclerotic, and cardioprotective activities, and many are applied widely for the treatment of CVD and its manifestations such as myocardial infarction, peripheral vascular diseases, and coronary heart disease. Natural drugs have significant advantages in the treatment of CVD due to their efficacy and safety profiles. Saponins are an important class of active components of plant natural products and play an important role in the treatment of CVD. This review covers the most up-to-date information on saponins concerning their cardioprotective effects and mechanisms of action.

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Corrigendum to “Ginsenoside Rd contributes the attenuation of cardiac hypertrophy in vivo and in vitro” [Biomed. Pharmacother. 109 (2019) 1016–1023]

Cited by 2 publications

References 0 publications

Graphene Quantum Dot‐PEI‐Cyclodextrin Nanocarrier for Simultaneous miR21a Delivery and Cell Imaging in Cancer Therapy

Graphene Quantum Dot‐PEI‐Cyclodextrin Nanocarrier for Simultaneous miR21a Delivery and Cell Imaging in Cancer Therapy

Cardioprotective Effects and Mechanisms of Saponins on Cardiovascular Disease

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