Corrigendum to “Injectable nanomaterials for drug delivery: Carriers, targeting moieties, and therapeutics” [Eur. J. Pharm. Biopharm. 84 (1) (May 2013) 1–20]

Webster, D. H.; Sundaram, Padma; Byrne, Mark E.

doi:10.1016/j.ejpb.2013.06.001

Cited by 7 publications

(6 citation statements)

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“…For instance, the covalent anchoring of such decaborate bearing silica precursors on silica matrices holds interest in the production of boron-silica based matrices (silica, glass, silicon substrate, silica nanoparticles, etc) ever since the latter gained notice in the field of medicine as drug carriers and probes. 16 Theoretically, the notion of incorporating the [B 10 H 10 ] 2− cluster into a biologically compatible luminescent silica-based drug carrier can facilitate the imaging process of tumours and their treatment with BNCT. 17 Since its emergence, BNCT has been plagued by the lack of suitable drug carriers.…”

Section: Introductionmentioning

confidence: 99%

New triethoxysilylated 10-vertex closo-decaborate clusters. Synthesis and controlled immobilization into mesoporous silica

et al. 2014

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Novel silylated hydroborate clusters comprising the closo-decaborate cage were prepared and characterized by (1)H, (13)C, (11)B, (29)Si NMR and mass spectroscopy ESI. The synthesis of such silylated clusters was achieved using reactive derivatives of [B10H10](2-), [1-B10H9N2](-) and [2-B10H9CO](-). These silylated decaborate clusters constitute a new class of precursors that can be covalently anchored onto various silica supports without any prior surface modification. As a proof of concept, the synthesized precursors were successfully anchored on mesoporous silica, SBA-15 type, in different percentages, where the mesoporous material retained its structure. All materials modified with closo-decaborate were characterized by (11)B and (29)Si solid state NMR, XRD, TEM and nitrogen sorption.

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Section: Introductionmentioning

confidence: 99%

New triethoxysilylated 10-vertex closo-decaborate clusters. Synthesis and controlled immobilization into mesoporous silica

et al. 2014

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“…Continuous work aimed at the search, development and introduction of new highly effective adjuvants has reduced the number of booster vaccines and the antigenic load on the body, significantly reducing the cost and simplifying the vaccination process. Despite the huge selection of adjuvants in experimental immunology, their use is limited [18][19][20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Veterinary sanitary assessment of chicken meat using squalene

et al. 2020

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One of the most promising sectors of agriculture is poultry farming. There are many unresolved problems, such as deaths of young birds during the first weeks of life due to the unstable immune system that develops by the end of the third week. The development and use of new immunomodulators (adjuvants) together with vaccines is a promising direction for enhancing and maintaining the natural resistance of birds and increasing their productive and economic indicators. The authors used a vaccine produced by VNIVIP – a branch of the Federal Scientific Center VNITIP RAS (St. Petersburg, Lomonosov). 45 chickens were divided into 3 groups. The control over the experimental birds was carried out until they are sixteen weeks old. An inactivated, emulsified vaccine with squalene in a dose of 0.5 cm3 was administered. Squalene is a natural unsaturated hydrocarbon which belongs to an extensive group of isoprenoids, which include Pcarotene, ubiquinone, and tocopherol. In its pure form, squalene is colorless oil, odorless and tasteless, characterized by physical and chemical stability and a high boiling point. 15 birds were vaccinated against the Newcastle disease without an adjuvant, and 15 remained intact. According to the results of organoleptic, physico-chemical and microscopic studies of chicken meat, it was found that the carcasses of experimental birds met the veterinary and sanitary requirements for high quality meat obtained from healthy birds and can be sold.

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“…All of these disadvantages have negative effect on the results of the treatment. To overcome this problem, a variety of drug delivery systems such as liposomes, polymer‐based carriers, micelles, graphene, carbon nanotubes, gold nanoparticles, super‐paramagnetic nanoparticles, and mesoporous silica nanoparticles have been developed to improve the therapeutic performance of individual drugs, endorsing site‐specific delivery. However, some critical issues such as toxic side effect, a low drug loading efficiency, costly and tedious material synthesis significantly limit the implementation of these carriers into clinical practice .…”

Section: Introductionmentioning

confidence: 99%

Intracellular Breakable and Ultrasound-Responsive Hybrid Microsized Containers for Selective Drug Release into Cancerous Cells

Timin

Muslimov

Lepik

et al. 2017

Part. Part. Syst. Charact.

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1 of 10) 1600417 This work reports an efficient and straightforward strategy to fabricate hybrid microsized containers with reduction-sensitive and ultrasound-responsive properties. The ultrasound and reductive sensitivity are visualized using scanning electron microscopy, with the results showing structural decomposition upon ultrasound irradiation and in the presence of reducing agent. The ultrasound-responsive functionalities of hybrid carriers can be used as external trigger for rapid controlled release, while prolonged drug release can be achieved in the presence of reducing agent. To evaluate the potential for targeted drug delivery, hybrid microsized containers are loaded with the anticancer drug doxorubicin (Dox). Such hybrid capsules can undergo structural intracellular degradation after cellular uptake by human cervical cancer cell line (HeLa), resulting in Dox release into cancer cells. In contrast, there is no Dox release when hybrid capsules are incubated with human mesenchymal stem cells (MSCs) as an example of normal human cells. The cell viability results indicate that Dox-loaded capsules effectively killed HeLa cells, while they have lower cytotoxicity against MSCs as an example of healthy cells. Thus, the newly developed intracellular-and ultrasound-responsive microcarriers obtained via sol-gel method and layer-by-layer technique provide a high therapeutic efficacy for cancer, while minimizing adverse side effect.

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Corrigendum to “Injectable nanomaterials for drug delivery: Carriers, targeting moieties, and therapeutics” [Eur. J. Pharm. Biopharm. 84 (1) (May 2013) 1–20]

Cited by 7 publications

References 0 publications

New triethoxysilylated 10-vertex closo-decaborate clusters. Synthesis and controlled immobilization into mesoporous silica

New triethoxysilylated 10-vertex closo-decaborate clusters. Synthesis and controlled immobilization into mesoporous silica

Veterinary sanitary assessment of chicken meat using squalene

Intracellular Breakable and Ultrasound-Responsive Hybrid Microsized Containers for Selective Drug Release into Cancerous Cells

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