Corrigendum to “M-CSF stimulated differentiation requires persistent MEK activity and MAPK phosporylation independent of Grb2–Sos association and phosphatidylinositol 3-kinase activity” [Cell. Signall. 17 (2005) 1352–1362]

E2a/Pbx1 oncogene inhibits terminal differentiation but not myeloid potential of pro-T cells

“…MEK inhibition converts M-CSF-R differentiation signal from macrophage to granulocyte pathway M-CSF-stimulated differentiation requires persistent mitogen-activated protein kinase (MAPK) kinase (MEK) activity (Gobert Gosse et al, 2005). M-CSF induced biphasic MAPK phosphorylation in EGERFms cells (Figure 5a), featuring the rapid and transient first wave, and late and persistent second wave, as previously described in a myeloid progenitor cell line (Bourgin et al, 2000).…”

“…Activation of the Ras to MAPK signaling pathway is essential for M-CSF-R differentiation signal (Gobert Gosse et al, 2005). In EGER-Fms cells, inhibition of MAPK activation not only prevented M-CSF-induced macrophage differentiation, but instead EGER-Fms cells differentiated into granulocytes, unveiling the latent granulocytic potential of EGER-Fms cells in addition to its macrophage potential.…”