Corrigendum to “Mind-body interactions in the regulation of airway inflammation in asthma: A PET study of acute and chronic stress” [Brain Behav. Immun. 58 (2016) 18–30]

Abstract

The authors regret that in this article, there was an error in the processing of the PET data for four participants, such that the order of the challenge conditions (stress or control) was incorrectly specified. As a consequence, the PET data were reprocessed. In reprocessing the data the general pipeline remained the same but FSL-and ANTS-based tools were used rather than SPM12. Only results pertaining to the PET data are affected by this error. The results from the corrected analysis are more straightforward and in better alignment with relationships between emotion and inflammation previously reported by our group and others. Some results from the original manuscript, however, were not present in the corrected analysis. In particular, results involving glucose metabolism in the anterior insula and its correlates, together with the conclusions drawn from these results, are invalid as a result of the challenge condition coding error. On the other hand, involvement of the anterior insula in the relationship between psychological stress and airway inflammation in asthma is still indicated by the corrected analyses. Several of the correlations between glucose metabolism in the insula and peripheral or behavioral measures change direction after the * Corresponding author. marosenk@wisc.edu (M.A. Rosenkranz).

Impact of asthma on the brain: evidence from diffusion MRI, CSF biomarkers and cognitive decline

“… 8–10 In asthma, a highly prevalent chronic inflammatory disease characterized by reversible airway hyper-responsiveness, 11 a growing body of evidence indicates bidirectional lung-brain communication. 12–17 Several epidemiological studies have found that asthma increases the risk of cognitive impairment and dementia 18–20 suggesting that the lung-brain axis might be involved. There are, however, some studies that have found mixed or no evidence of the deleterious impact of asthma on brain health, 21–23 which highlights multiple challenges in determining the contribution of a particular inflammatory condition to dementia risk, such as the presence of other co-morbid conditions that might accentuate risk 7 or the potential protective effect of anti-inflammatory medications.…”