Corrigendum to molecular genetics and emerging therapies for retinitis pigmentosa: Basic research and clinical perspective progress in retinal and eye research (2018) Vol 63,107-131

Dias, Marina França; Joo, Kwangsic; Kemp, Jessica A.; Cunha, Armando da Silva; Woo, Se Joon; Kwon, Young Jik

doi:10.1016/j.preteyeres.2018.08.001

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1 It is estimated that approximately 2.5 million patients suffer from this disorder worldwide. 2 With updated molecular tools, the genetics and molecular bases of RP have been identified in multiple studies, contributing to the development of gene therapies targeting several mutations for visual restoration. 3,4 Additionally, cell-based therapies are proposed to treat blinding retinal disorders, including RP and macular degeneration.…”

Section: Introductionmentioning

confidence: 99%

“…Retinitis pigmentosa (RP) is a retinopathy characterized by the death of rod photoreceptors induced by multiple mutations and slow degeneration of cone photoreceptors, leading to visual dysfunction and, eventually, blindness in bilateral eyes 1 . It is estimated that approximately 2.5 million patients suffer from this disorder worldwide 2 . With updated molecular tools, the genetics and molecular bases of RP have been identified in multiple studies, contributing to the development of gene therapies targeting several mutations for visual restoration 3,4 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Protective mechanism of TCF7L1 against retinal photoreceptor cell injury following retinitis pigmentosa based on the GEO database

Yin

Niu

et al. 2023

The FASEB Journal

View full text Add to dashboard Cite

Recent studies have reported the promising value of differential gene expression analysis and weighted gene coexpression network analysis (WGCNA) for identifying disease biomarkers. Based on this method, this study intends to characterize the hub genes and pathways related to retinal photoreceptor cell (PRC) injury in the context of retinitis pigmentosa (RP). A total of 53 coexpression modules were identified by WGCNA, among which lightpink4, darkolivegreen, tan4, blue2, skyblue2, and navajowhite2 ranked at the top. By analyzing the RP microarrays retrieved from the GEO database, 338 differentially expressed genes (DEGs) were identified in the RP samples. Forty-five candidate genes were selected from these DEGs by intersection with the genes in the coexpression modules. These intersection genes were subjected to GO and KEGG analyses. Furthermore, the genes and pathways involved in PRC damage were identified based on analyses utilizing GeneCards and STRING tools. Transcription factor 7-like 1 (TCF7L1, also called TCF3) was suggested to participate in the RP-associated PRC damage through the Wnt signaling pathway. It was validated in a blue light-irradiated cell model that TCF7L1 overexpression boosted PRC viability and repressed apoptosis. Inhibition of the Wnt signaling pathway also contributed to protective effects. Together, the data mentioned above supported the conclusion that either elevation of TCF7L1 or blockade of the Wnt signaling pathway could prevent RP progression by protecting PRCs from damage.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Protective mechanism of TCF7L1 against retinal photoreceptor cell injury following retinitis pigmentosa based on the GEO database

Yin

Niu

et al. 2023

The FASEB Journal

View full text Add to dashboard Cite

show abstract

Integrative Single‐Cell Transcriptomics and Epigenomics Mapping of the Fetal Retina Developmental Dynamics

Liu

et al. 2023

Advanced Science

View full text Add to dashboard Cite

The underlying mechanisms that determine gene expression and chromatin accessibility in retinogenesis are poorly understood. Herein, single-cell RNA sequencing and single-cell assay for transposase-accessible chromatin sequencing are performed on human embryonic eye samples obtained 9-26 weeks after conception to explore the heterogeneity of retinal progenitor cells (RPCs) and neurogenic RPCs. The differentiation trajectory from RPCs to 7 major types of retinal cells are verified. Subsequently, diverse lineage-determining transcription factors are identified and their gene regulatory networks are refined at the transcriptomic and epigenomic levels. Treatment of retinospheres, with the inhibitor of RE1 silencing transcription factor, X5050, induces more neurogenesis with the regular arrangement, and a decrease in Müller glial cells. The signatures of major retinal cells and their correlation with pathogenic genes associated with multiple ocular diseases, including uveitis and age-related macular degeneration are also described. A framework for the integrated exploration of single-cell developmental dynamics of the human primary retina is provided.

show abstract

Corrigendum to molecular genetics and emerging therapies for retinitis pigmentosa: Basic research and clinical perspective progress in retinal and eye research (2018) Vol 63,107-131

Cited by 2 publications

References 0 publications

Protective mechanism of TCF7L1 against retinal photoreceptor cell injury following retinitis pigmentosa based on the GEO database

Protective mechanism of TCF7L1 against retinal photoreceptor cell injury following retinitis pigmentosa based on the GEO database

Integrative Single‐Cell Transcriptomics and Epigenomics Mapping of the Fetal Retina Developmental Dynamics

Contact Info

Product

Resources

About