Corrigendum to “Restoration of HCV-specific T cell functions by PD-1/PD-L1 blockade in HCV infection: Effect of viremia levels and antiviral treatment” [J Hepatol 48 (2008) 548–558]

Immunopathogenesis and Immunotherapy for Viral Hepatitis

“…Recently, HCV core protein was shown to induce PD-1 and PD-L1 on T cells from healthy donors (Yao et al, 2007), indicating that immunosuppressive ability of HCV core protein is mediated by the upregulation of inhibitory molecules on T cells. Increased PD-1 expression on HCV-specific CTLs was reported to be significantly associated with poor response to antiviral therapy (Golden-Mason et al, 2008), and PD-L1 expression on DCs is increased during IFN-a treatment (Urbani et al, 2008), suggesting that PD-1/PD-L1 is associated with the efficacy of antiviral treatment. PD-1 is also expressed on Tregs in the liver, and the signal from PD-1 ligation provides an overall inhibitory signal t o T r e g s .…”

Viral Hepatitis - Selected Issues of Pathogenesis and Diagnostics

“…Recently, HCV core protein was shown to induce PD-1 and PD-L1 on T cells from healthy donors (Yao et al, 2007), indicating that immunosuppressive ability of HCV core protein is mediated by the upregulation of inhibitory molecules on T cells. Increased PD-1 expression on HCV-specific CTLs was reported to be significantly associated with poor response to antiviral therapy , and PD-L1 expression on DCs is increased during IFN-a treatment (Urbani et al, 2008), suggesting that PD-1/PD-L1 is associated with the efficacy of antiviral treatment. PD-1 is also expressed on Tregs in the liver, and the signal from PD-1 ligation provides an overall inhibitory signal to Tregs.…”