Corrigendum to “Sesamin suppresses NSCLC cell proliferation through cyclin D1 inhibition-dependent cell cycle arrest via Akt/p53 pathway” [Toxicology and applied pharmacology, 387 (2020) 114848]

Chen, Yueming; Li, Huachao; Zhang, Weinan; Qi, Wanchen; Lu, Changpeng; Huang, Huiliang; Yang, Zhicheng; Liu, Bing; Zhang, Luyong

doi:10.1016/j.taap.2020.115048

Cited by 1 publication

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“… 38 - 41 Sesamin modulates the AKT/P53 signaling pathway, mainly inhibits AKT activity, and downregulates cyclin D1 and CDK2 in A549 and H1792 lung cancer cells. 42 In a previous study, sesamin suppressed AKT/PI3K signaling by downregulating cyclooxygenase 2, leading to G 1 phase cell arrest, and down-regulating Bcl-2, Bax and cyclin E1 gene expression. 43 Yang et al 44 showed that sesamin causes an increase in the production of ROS in A549 cells and loss of the mitochondrial membrane potential.…”

Section: Herbal Medicine Extracts Commonly Used In Nsclc Treatmentmentioning

confidence: 90%

Traditional Herbal Medicine: A Potential Therapeutic Approach for Adjuvant Treatment of Non-small Cell Lung Cancer in the Future

Huang

et al. 2022

Integr Cancer Ther

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Lung carcinoma is the primary reason for cancer-associated mortality, and it exhibits the highest mortality and incidence in developed and developing countries. Non-small cell lung cancer (NSCLC) and SCLC are the 2 main types of lung cancer, with NSCLC contributing to 85% of all lung carcinoma cases. Conventional treatment mainly involves surgery, chemoradiotherapy, and immunotherapy, but has a dismal prognosis for many patients. Therefore, identifying an effective adjuvant therapy is urgent. Historically, traditional herbal medicine has been an essential part of complementary and alternative medicine, due to its numerous targets, few side effects and substantial therapeutic benefits. In China and other East Asian countries, traditional herbal medicine is increasingly popular, and is highly accepted by patients as a clinical adjuvant therapy. Numerous studies have reported that herbal extracts and prescription medications are effective at combating tumors. It emphasizes that, by mainly regulating the P13K/AKT signaling pathway, the Wnt signaling pathway, and the NF-κB signaling pathway, herbal medicine induces apoptosis and inhibits the proliferation and migration of tumor cells. The present review discusses the anti-NSCLC mechanisms of herbal medicines and provides options for future adjuvant therapy in patients with NSCLC.

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Section: Herbal Medicine Extracts Commonly Used In Nsclc Treatmentmentioning

confidence: 90%

Traditional Herbal Medicine: A Potential Therapeutic Approach for Adjuvant Treatment of Non-small Cell Lung Cancer in the Future

Huang

et al. 2022

Integr Cancer Ther

View full text Add to dashboard Cite

show abstract

Corrigendum to “Sesamin suppresses NSCLC cell proliferation through cyclin D1 inhibition-dependent cell cycle arrest via Akt/p53 pathway” [Toxicology and applied pharmacology, 387 (2020) 114848]

Cited by 1 publication

References 0 publications

Traditional Herbal Medicine: A Potential Therapeutic Approach for Adjuvant Treatment of Non-small Cell Lung Cancer in the Future

Traditional Herbal Medicine: A Potential Therapeutic Approach for Adjuvant Treatment of Non-small Cell Lung Cancer in the Future

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