Corrigendum to “The neoglycolipid (NGL)-based oligosaccharide microarray system poised to decipher the meta-glycome” [Curr Opin Chem Biol 18 (2014) 87–94]

Electrochemistry of Nonconjugated Proteins and Glycoproteins. Toward Sensors for Biomedicine and Glycomics

“…Although antibodies raised against glycan moieties can detect glycans on glycoproteins with higher affinity and specificity as compared to lectins, ,, their application in direct glycoprofiling of proteins is questionable due to their limited commercial availability . However, when available, they can be effective in early cancer detection. ,, Most importantly, carbohydrate arrays can assist in finding novel glycan specificities of already utilized antibodies and lectins. ,− Because lectins are almost exclusively applied in direct glycoprofiling of glycoproteins, details about their integration into EC formats of detection will be discussed in the forthcoming sections.…”

Multivalent glycan arrays

“…The neoglycolipids were prepared by reductive amination of the sugar compound and an amino-conjugated lipid. [59][60][61][62][63][64][65][66][67][68] A similar attachment strategy used uorous tagged glycans for immobilization on a Teon/ epoxy coated glass slide. [69][70][71] The peruorinated alkyl chain allows for easy puri-cation and permits strong binding to the surface that survives extensive washing steps.…”

Rapid Identification of the Receptor‐Binding Specificity of Influenza A Viruses by Fluorogenic Glycofoldamers

“…Conventional approaches to meet this goal rely on the hemagglutination/hemagglutinin inhibition assay, which requires strict quality control, long detection times, and is rather expensive. New elegant strategies, including the glyco‐microarray and other surface‐based and nanoparticle‐based analytical methods, have been developed for virus detection. However, several problems still exist.…”

“…The pyrene‐naphthalimide dyad was synthesized by coupling pyrene ( p ) to a naphthalimide derivative ( n ) with a flexible alkyl chain (Scheme S1). Then, an aminoxy handle was installed at the naphthalimide moiety by a click reaction, offering a reaction site for glycans . The desired glycofoldamers TO26 , TN26 , P26 , TO23 , TN23 , P23 , and 1 (control) were produced in good yields through oxime ligation (Scheme S2 and Figure ).…”