Corrigendum to “The novel mitochondrial iron chelator 5-((methylamino)methyl)-8-hydroxyquinoline protects against mitochondrial-induced oxidative damage and neuronal death” [Biochem. Biophys. Res. Commun. 463 (4) (2015) 787–792]

Mena, Natalia; García‐Beltrán, Olimpo; Lourido, Fernanda; Urrutia, Pamela J.; Mena, Raúl; Castro-Castillo, Vicente; Cassels, Bruce K.; Núñez, Marco T.

doi:10.1016/j.bbrc.2016.03.070

Cited by 2 publications

(3 citation statements)

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“…Therefore, preventing mitochondrial dysfunction could be an effective therapeutic strategy for cellular degenerative processes. [27][28][29] Melatonin (N-acetyl-5-methoxytryptamine), a major secretory product of the pineal gland, is a well-known antioxidant and therefore an effective protector of mitochondrial bioenergetic function. Melatonin is a conserved molecule derived from tryptophan found in all organisms, from unicellular organisms to vertebrates.…”

Section: Introductionmentioning

confidence: 99%

Melatonin loaded PLGA nanoparticles effectively ameliorate the in vitro maturation of deteriorated oocytes and the cryoprotective abilities during vitrification process

et al. 2023

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Section: Introductionmentioning

confidence: 99%

Melatonin loaded PLGA nanoparticles effectively ameliorate the in vitro maturation of deteriorated oocytes and the cryoprotective abilities during vitrification process

et al. 2023

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“…derivatives substituted with 5-methylamino (17) and 5-morpholinomethyl (18) groups were designed and reported for their neuroprotective potentials in both cellular and in vivo models of PD. 112 Both compounds effectively rescued dopaminergic neuronal cell line (SHSY-5Y) from oxidative-induced damage via acting as Fe chelators to decrease the levels of Fe in mitochondrial and cytoplasmic pools, thereby, suppressed ROS production. 112 Additionally, compound 19 (HLA-20A) was developed as a site-activated multifunctional chelators of the parent chelator, HLA-20.…”

Section: Hq-based Compounds As Fe Chelators and Zn Ionophoresmentioning

confidence: 99%

“…112 Both compounds effectively rescued dopaminergic neuronal cell line (SHSY-5Y) from oxidative-induced damage via acting as Fe chelators to decrease the levels of Fe in mitochondrial and cytoplasmic pools, thereby, suppressed ROS production. 112 Additionally, compound 19 (HLA-20A) was developed as a site-activated multifunctional chelators of the parent chelator, HLA-20. 113 The compound 19 was designed as a prochelator (inactive) by incorporating the crucial structure (a carbamate group) of two cholinesterase inhibitors (i.e., rivastigmine and donepezil).…”

Section: Hq-based Compounds As Fe Chelators and Zn Ionophoresmentioning

confidence: 99%

8-Hydroxyquinolines: A Promising Pharmacophore Potentially Developed as Disease-Modifying Agents for Neurodegenerative Diseases: A Review

Prachayasittikul,

Pingaew,

Prachayasittikul

et al. 2022

HETEROCYCLES

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8-Hydroxyquinoline (8HQ) is an attractive heterocyclic scaffold with well-known metal chelating property, broad-ranging pharmacological activities, and preferrable drug-likeness, thus, it had gained a continual attention in areas of drug development, especially, drug repurposing. Alzheimer's disease (AD) is one of globally health concern in an era of aging society and its management is considered challenging as effective disease-modifying drugs are still clinically unavailable. Loss of metal ion homeostasis is one of key factors contributing to pathogenesis and progression of AD in which its imbalance could trigger many related key factors and harmful events, especially, oxidative neuronal damages.Hence, restoration of homeostasis and distribution of brain's metal ions served to be a promising strategy for development of disease-modifying agents. In this review, essential key points relating to AD pathogenesis, roles of metal ions in AD, and pioneer 8HQ-based compounds are introduced. A series of recently reported 8HQbased neuroprotective compounds (i.e., derivatives, hybrids, conjugates, and metal complexes) focusing on compounds acting as metal chelators are reviewed. Related 8HQ-based neuroprotective compounds with other mechanisms of actions are also discussed. Additionally, summary of key contents is included to provide an 202

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Corrigendum to “The novel mitochondrial iron chelator 5-((methylamino)methyl)-8-hydroxyquinoline protects against mitochondrial-induced oxidative damage and neuronal death” [Biochem. Biophys. Res. Commun. 463 (4) (2015) 787–792]

Cited by 2 publications

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Melatonin loaded PLGA nanoparticles effectively ameliorate the in vitro maturation of deteriorated oocytes and the cryoprotective abilities during vitrification process

Melatonin loaded PLGA nanoparticles effectively ameliorate the in vitro maturation of deteriorated oocytes and the cryoprotective abilities during vitrification process

8-Hydroxyquinolines: A Promising Pharmacophore Potentially Developed as Disease-Modifying Agents for Neurodegenerative Diseases: A Review

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