Corrigendum to “Toxic Effects of Trazodone on Male Reproductive System via Disrupting Hypothalamic‐Pituitary‐Testicular Axis and Inducing Testicular Oxidative Stress”

Ilgın, Sinem; Kılıç, Gözde; Baysal, Merve; Kılıç, Volkan; Ardıç, Mina; Uçarcan, Şeyda; Atlı, Özlem

doi:10.1155/2018/8294061

Cited by 1 publication

(2 citation statements)

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“…A study found that TRZ administration reduced sperm concentration in male rats, motility, and normal morphology while increasing sperm DNA damage and testicular degeneration. Elevated serum levels of FSH, LH, and testosterone, along with oxidative stress in testicular tissue, were also observed ( Ilgın et al, 2018 ). These hormonal changes were associated with decreased sperm quality and testicular degeneration.…”

Section: Neurotherapeutic Drugs and Reproductive Healthmentioning

confidence: 99%

“…These hormonal changes were associated with decreased sperm quality and testicular degeneration. Additionally, trazodone exposure led to oxidative stress, as indicated by elevated levels of malondialdehyde (MDA) in testicular tissue, reflecting lipid peroxidation ( Rahal et al, 2014 ; Sabeti et al, 2016 ; Ilgın et al, 2018 ). Clinical research on patients undergoing TRZ treatment is crucial for identifying potential reproductive toxicity, emphasizing the importance of monitoring sperm parameters before, during, and after TRZ therapy.…”

Section: Neurotherapeutic Drugs and Reproductive Healthmentioning

confidence: 99%

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The reprotoxic adverse side effects of neurogenic and neuroprotective drugs: current use of human organoid modeling as a potential alternative to preclinical models

Abady,

Jeong,

Kwon

et al. 2024

Front. Pharmacol.

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The management of neurological disorders heavily relies on neurotherapeutic drugs, but notable concerns exist regarding their possible negative effects on reproductive health. Traditional preclinical models often fail to accurately predict reprotoxicity, highlighting the need for more physiologically relevant systems. Organoid models represent a promising approach for concurrently studying neurotoxicity and reprotoxicity, providing insights into the complex interplay between neurotherapeutic drugs and reproductive systems. Herein, we have examined the molecular mechanisms underlying neurotherapeutic drug-induced reprotoxicity and discussed experimental findings from case studies. Additionally, we explore the utility of organoid models in elucidating the reproductive complications of neurodrug exposure. Have discussed the principles of organoid models, highlighting their ability to recapitulate neurodevelopmental processes and simulate drug-induced toxicity in a controlled environment. Challenges and future perspectives in the field have been addressed with a focus on advancing organoid technologies to improve reprotoxicity assessment and enhance drug safety screening. This review underscores the importance of organoid models in unraveling the complex relationship between neurotherapeutic drugs and reproductive health.

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Section: Neurotherapeutic Drugs and Reproductive Healthmentioning

confidence: 99%