2023
DOI: 10.1002/rmb2.12527
|View full text |Cite
|
Sign up to set email alerts
|

Corroborating evidence for aberrant expression of histone deacetylase 8 in endometriosis

Abstract: PurposeThe aim of this study was to evaluate the dynamic change in staining of Class I HDACs and Hdac6 in lesions harvested serially from different time points in mice with induced endometriosis. In addition, the effect of Hdac8 activation as well as Hdac8 and Hdac6 inhibition on lesional progression and fibrogenesis was evaluated.MethodsImmunohistochemistry analysis of Class I HDACs and Hdac6 in serially harvested lesion samples in mouse. Hdac8 activation, as well as Hdac6/8 inhibition, was evaluated in mice … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

2
5
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
4
1

Relationship

1
4

Authors

Journals

citations
Cited by 7 publications
(7 citation statements)
references
References 89 publications
2
5
0
Order By: Relevance
“…In addition, the extent of lesional fibrosis correlated positively with the lesional staining of HDAC8 and HDAC6 in both the epithelial and stromal components (r = 0.64, p = 2.7 × 10 −10 , r = 0.75, p = 2.3 × 10 −15 , r = 0.59, p = 2.0 × 10 −8 , r = 0.41, p = 2.3 × 10 −4 , respectively; Figure3E-H). Of note, these correlations were consistent with what we observed in serially harvested lesions from mice with induced endometriosis 72.…”
supporting
confidence: 90%
See 4 more Smart Citations
“…In addition, the extent of lesional fibrosis correlated positively with the lesional staining of HDAC8 and HDAC6 in both the epithelial and stromal components (r = 0.64, p = 2.7 × 10 −10 , r = 0.75, p = 2.3 × 10 −15 , r = 0.59, p = 2.0 × 10 −8 , r = 0.41, p = 2.3 × 10 −4 , respectively; Figure3E-H). Of note, these correlations were consistent with what we observed in serially harvested lesions from mice with induced endometriosis 72.…”
supporting
confidence: 90%
“…Given the results of the above ex vivo experiments and in view of the in vivo results that HDAC8 activation accelerated, while HDAC8 inhibition decelerated lesional progression and fibrogenesis, 72 we speculated that inhibition of HDAC8 may have a therapeutic effect. Consequently, we next evaluated the potential therapeutic effect of PCI‐34051 (PCI), an HDAC8‐specific inhibitor, on mice with induced deep endometriosis.…”
Section: Resultsmentioning
confidence: 96%
See 3 more Smart Citations