Corrosion degradation and prevention by surface modification of biometallic materials

Singh, Raghuvir; Dahotre, Narendra B.

doi:10.1007/s10856-006-0016-y

Cited by 226 publications

(155 citation statements)

References 256 publications

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“…[18][19][20] To date, surgical stainless steel 316L (SS) is one of the most frequently used biomaterials because of a favorable combination of strength, good fabrication properties, low inherent toxicity, minimal reactivity with biomolecules, and cost efficiency when compared with other metallic implant materials. 1,21 The aims of this study were firstly, to investigate whether human monocytes are able to grow on SS implants and differentiate into mature OC. Secondly, to test the hypothesis that mature OC are able to directly corrode SS and release corresponding metal ions into the peri-implant environment, which may subsequently induce inflammatory reactions.…”

mentioning

confidence: 99%

Bio‐corrosion of stainless steel by osteoclasts—in vitro evidence

Cadosch

Chan

Gautschi

et al. 2008

Journal Orthopaedic Research

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Most metals in contact with biological systems undergo corrosion by an electrochemical process. This study investigated whether human osteoclasts (OC) are able to grow on stainless steel (SS) and directly corrode the metal alloy leading to the formation of corresponding metal ions, which may cause inflammatory reactions and activate the immune system. Scanning electron microscopy analysis demonstrated long-term viable OC cultures and evident resorption features on the surface of SS discs on which OC were cultured for 21 days. The findings were confirmed by atomic emission spectrometry investigations showing significantly increased levels of chromium, nickel, and manganese in the supernatant of OC cultures. Furthermore, significant levels of pro-inflammatory cytokines IL-1b, IL-6, and TNF-a, which are considered to be major mediators of osteolysis, were revealed in the same cultures by cytometric bead array analysis. Within the present study, it was shown that human osteoclast precursors are able to grow and differentiate towards mature OC on SS. The mature cells are able to directly corrode the metal surface and release corresponding metal ions, which induce the secretion of pro-inflammatory cytokines that are known to enhance osteoclast differentiation, activation, and survival. Enhanced corrosion and the subsequently released metal ions may therefore result in enhanced osteolytic lesions in the peri-prosthetic bone, contributing to the aseptic loosening of the implant. Keywords: osteoclast; bio-corrosion; stainless steel; osteolysis; TNF-a Over the last decades, significant developments have been taking place to provide suitable metal alloys for implants with optimal mechanical characteristics and good biocompatibility with minimal adverse host tissue reactions. 1 However, their permanent tendency to corrode when exposed to a physiological environment remains a serious concern. 2-4 Elevated concentrations of metal ions have been measured in clinically retrieved peri-prosthetic tissues, distal organs, and body fluids in total hip arthroplasty patients. [5][6][7] The biology behind corrosion inside the human body and the distribution of the metal ions throughout the organism is not fully understood. It has been suggested that extracellular body fluids have corrosive proprieties and contain metal binding proteins. 2,3 Furthermore, it has been debated whether osteoclasts (OC) are able to corrode pure metal when entering into contact with metal surfaces. However, direct evidence of metal corrosion by OC has been missing to date.Osteoclasts are highly specialized multinucleated cells, which are capable of bone resorption. They are formed by the fusion of marrow-derived mononuclear precursors, which circulate in the peripheral blood. Osteoclastic differentiation from hematopoietic and circulating monocytes occurs in the presence of macrophage-colony stimulating factor (M-CSF) and the receptor activator of NF-kB ligand (RANK-L) which are expressed on osteoblastic cells. 8 Mature OC display distinct morpholog...

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mentioning

confidence: 99%

Bio‐corrosion of stainless steel by osteoclasts—in vitro evidence

Cadosch

Chan

Gautschi

et al. 2008

Journal Orthopaedic Research

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“…Hardy & Kendall (2005) have reported that particle diameters ranging from 25 to 100 mm are expected to follow the extracellular route, as their momentum is insufficient to breach the target barrier, due to the combination of relatively low density and small size. It has been recommended that stainless steel or polymer micro-particles should be used for extracellular routes, due to their biocompatibility and low cost (Disegi & Eschbach, 2000;Binyamin et al, 2006;Singh & Dahotre, 2007;Soliman, 2011;Sung et al, 2011).…”

Section: Micro-particle Materials and Sizementioning

confidence: 99%

Potential of microneedle-assisted micro-particle delivery by gene guns: a review

2013

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“…Porous metals that are commonly used for biomedical applications are titanium and titanium alloys, Cobalt Chrome and nitinol shape memory alloys and stainless steel 316L [1]. Amongst all, stainless steel 316L is the longest being applied in the biomedical implant which is since 1920's [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…Amongst all, stainless steel 316L is the longest being applied in the biomedical implant which is since 1920's [1,2]. Stainless steel 316L are low cost, easy availability and processing, good workability, high fatigue life and fracture toughness [1,3,4].…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Porous Stainless Steel 316L for Biomedical Applications

2017

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Abstract. Porous metals are very attractive materials for biomedical application as the physical and mechanical properties of these materials can be tailored similarly to the natural bone. In this work, porous stainless steel 316L has been fabricated by foam replication method. This method offers a lot of advantages including of easy processing technique, very economic, does not involve the use of toxic chemical and capable of producing porous structure that almost similar to natural bone. The porous stainless steel 316L (SS316L) samples were prepared by varying the SS316L composition from 40 wt% to 60 wt%. Sintering process was carried out at 1250C in a vacuum furnace. The microstructure and pore size were observed and determined through Scanning Electron Microscope (SEM). Archimedes method was used to measure the samples density, while compression test was carried out to determine the compressive strength and elastic modulus. The average pore size for samples with 50 wt% and 60 wt% SS316L are 268µm and 299µm respectively. Samples with 40 wt% SS316L experienced the largest shrinkage which is 33% while the sample with 60 wt% SS316L experienced the smallest shrinkage which is 21%. The density and porosity of the porous SS316L with 50 wt% SS316L are 0.43g/cm3 and 93.6% respectively, and for porous SS316L with 60 wt% SS316L are 0.69 g/cm3 and 89.2% respectively. The modulus of elasticity and compressive strength for porous SS316L with 60 wt% SS316L are 0.46 GPa and 56 MPa respectively. All these properties are in the range of the natural bone properties. Besides, the cytotoxicity test showed that this porous SS316L does not have a cytotoxic potential for biomedical implant.

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Corrosion degradation and prevention by surface modification of biometallic materials

Cited by 226 publications

References 256 publications

Bio‐corrosion of stainless steel by osteoclasts—in vitro evidence

Bio‐corrosion of stainless steel by osteoclasts—in vitro evidence

Potential of microneedle-assisted micro-particle delivery by gene guns: a review

Fabrication of Porous Stainless Steel 316L for Biomedical Applications

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