Corrosion Mechanisms of a Biodegradable Zn-0.4Li Alloy in Simulated Gastrointestinal Environment

Wang, Manli; Yang, Lingbo; Zhu, Xinglong; Yang, Lijing; Shen, Jianwei; Lu, Ting; Liu, Huinan; Zhang, Song

doi:10.3390/coatings13030529

Cited by 3 publications

(1 citation statement)

References 75 publications

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“…Indeed, there is currently a limited range of systems being considered for the development of biodegradable medical devices. The most extensively studied alloying elements for biodegradable medical devices include Mg [16,19], Li [20,21], Mn [21], Cu [21,22], Ca [16], Ag [23], Fe [24], Sr [16,25], and Zr [26]. These elements have a good effect on the strength, corrosion resistance, and biocompatibility of Zn.…”

Section: Introductionmentioning

confidence: 99%

Improved Mechanical Properties of Biocompatible Zn-1.7%Mg and Zn1.7%Mg-0.2%Zr Alloys Deformed with High-Pressure Torsion

Martynenko,

Anisimova,

Tabachkova

et al. 2023

Metals

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The potential medical Zn-1.7%Mg and Zn-1.7%Mg-0.2%Zr alloys strengthened using high-pressure torsion (HPT) were investigated in this work. HPT led to a significant refinement of the microstructure of both alloys with the formation of an ultrafine-grained structure (UFG). The average grain size after HPT was ~700–800 nm for both alloys. The formation of the UFG structure led to an increase in the ultimate tensile strength of up to 401 ± 16 and 482 ± 12 MPa for the Zn-1.7%Mg and Zn-1.7%Mg-0.2%Zr alloys, respectively. Additionally, a variation in ductility of the Zn-1.7%Mg and Zn-1.7%Mg-0.2%Zr alloys of up to 56.3 ± 16.9% and 4.4 ± 0.6%, respectively, was also observed, apparently due to textural changes. HPT led to a small increase in the degradation rate of the alloys after 1 day of incubation in the medium. However, an increase in the incubation period of up to 30 days slowed down the degradation process and leveled the difference between the initial and HPT-treated state of the alloys. HPT did not affect the cytotoxicity of the Zn-1.7%Mg-0.2%Zr alloy and contributed to the reduction of hemolysis. Thus, the processing of the Zn-1.7%Mg and Zn-1.7%Mg-0.2%Zr alloys using HPT accelerated their biodegradation without compromising their biocompatibility.

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Section: Introductionmentioning

confidence: 99%

Improved Mechanical Properties of Biocompatible Zn-1.7%Mg and Zn1.7%Mg-0.2%Zr Alloys Deformed with High-Pressure Torsion

Martynenko,

Anisimova,

Tabachkova

et al. 2023

Metals

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In-vitro corrosion behavior and mechanical properties of biodegradable Zn alloys designed for gastrointestinal anastomosis

Wang,

Zhu

et al. 2024

Journal of Materials Research and Technology

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Coated Biodegradable Zinc Lithium Alloys: Development and Characterization of Co-Doped Strontium Copper Tricalcium Phosphate Coating for Antimicrobial Applications

Rau,

De Bonis,

Curcio

et al. 2024

Coatings

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Zinc biodegradable implants represent a revolutionary advancement in medical technology, offering a promising alternative to titanium and stainless-steel implants and avoiding the need for secondary surgeries for removal. In this study, we aimed to fulfil the clinical demand for biodegradable implant materials by applying a coating of double-doped strontium and copper resorbable tricalcium phosphate (SrCu-TCP) onto a zinc-lithium (Zn-Li) biodegradable alloy using the Pulsed Laser Deposition method. The coated surfaces were thoroughly characterized using X-ray Diffraction, Fourier Transform Infrared Spectroscopy, Atomic Force Microscopy, and Scanning Electron Microscopy coupled with Energy Dispersive X-ray. Microbiology experiments were conducted to assess the inhibitory effects on the growth of various bacteria strains, including gram-positive Staphylococcus aureus and Enterococcus faecalis, gram-negative Pseudomonas aeruginosa and Escherichia coli, as well as the fungus Candida albicans. The obtained results showed that the roughness of the Zn-Li alloy increased from 91.8 ± 29.4 to 651.0 ± 179.5 nm when coated with SrCu-TCP. The thickness of the coating ranged between 3–3.5 µm. The inhibition of growth for all four bacteria strains and the fungus was in the range of 24–35% when cultured on SrCu-TCP coated Zn-Li samples. These findings suggest that the developed coatings are promising candidates for applications requiring inhibition of microorganisms.

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Corrosion Mechanisms of a Biodegradable Zn-0.4Li Alloy in Simulated Gastrointestinal Environment

Cited by 3 publications

References 75 publications

Improved Mechanical Properties of Biocompatible Zn-1.7%Mg and Zn1.7%Mg-0.2%Zr Alloys Deformed with High-Pressure Torsion

Improved Mechanical Properties of Biocompatible Zn-1.7%Mg and Zn1.7%Mg-0.2%Zr Alloys Deformed with High-Pressure Torsion

In-vitro corrosion behavior and mechanical properties of biodegradable Zn alloys designed for gastrointestinal anastomosis

Coated Biodegradable Zinc Lithium Alloys: Development and Characterization of Co-Doped Strontium Copper Tricalcium Phosphate Coating for Antimicrobial Applications

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