Corrosion Resistance and Biocompatibility Assessment of a Biodegradable Hydrothermal-Coated Mg–Zn–Ca Alloy: An in Vitro and in Vivo Study

Xi, Zheng; Wu, Yunfeng; Xiang, Shou-Yang; Sun, Changfu; Wang, Yongxuan; Yu, Haiming; Fu, Yu; Wang, Xintao; Yan, Jinglong; Zhao, Dewei; Wang, Yaming; Zhang, Nan

doi:10.1021/acsomega.9b03889

Cited by 27 publications

(9 citation statements)

References 47 publications

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“…In one study that used pure Mg, contamination around the bone by corrosion products was observed [3], and in a study where the author used an alloy of Mg-4Li-3.6Al-2.4REE (wt.%), REE contamination around the implanted alloy and in vital organs was reported [12]. The use of pure Mg metal did not significantly increase the level of Mg in the blood or surrounding organs [11,[26][27][28]. The rate of corrosion and resorption of the experimental metal was faster for pure magnesium [3] compared to magnesium alloys with the addition of Sr [25].…”

Section: Introductionmentioning

confidence: 99%

“…Payr also described an intramedullary stabilising rod for the treatment of non-union fractures [7]. Magnesium-based materials with absorbable properties have been extensively studied since the turn of 20th century and have been used for the treatment of (i) vessel stenting [9], (ii) intestinal anastomoses [7], and (iii) bone implants [1,7,10], both in experimental animals [2,3,11,12] and also in humans [1,10]. Even though Mg-based materials are now readily used in surgical practice [10,13,14], they still possess some drawbacks-preventing their wide use in surgery.…”

Section: Introductionmentioning

confidence: 99%

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Zn–0.8Mg–0.2Sr (wt.%) Absorbable Screws—An In-Vivo Biocompatibility and Degradation Pilot Study on a Rabbit Model

et al. 2021

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In this pilot study, we investigated the biocompatibility and degradation rate of an extruded Zn–0.8Mg–0.2Sr (wt.%) alloy on a rabbit model. An alloy screw was implanted into one of the tibiae of New Zealand White rabbits. After 120 days, the animals were euthanized. Evaluation included clinical assessment, microCT, histological examination of implants, analyses of the adjacent bone, and assessment of zinc, magnesium, and strontium in vital organs (liver, kidneys, brain). The bone sections with the implanted screw were examined via scanning electron microscopy and energy dispersive spectroscopy (SEM-EDS). This method showed that the implant was covered by a thin layer of phosphate-based solid corrosion products with a thickness ranging between 4 and 5 µm. Only negligible changes of the implant volume and area were observed. The degradation was not connected with gas evolution. The screws were fibrointegrated, partially osseointegrated histologically. We observed no inflammatory reaction or bone resorption. Periosteal apposition and formation of new bone with a regular structure were frequently observed near the implant surface. The histological evaluation of the liver, kidneys, and brain showed no toxic changes. The levels of Zn, Mg, and Sr after 120 days in the liver, kidneys, and brain did not exceed the reference values for these elements. The alloy was safe, biocompatible, and well-tolerated.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Zn–0.8Mg–0.2Sr (wt.%) Absorbable Screws—An In-Vivo Biocompatibility and Degradation Pilot Study on a Rabbit Model

et al. 2021

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“…The low surface energy inhibited the adhesion and growth of E. coli and S. aureus by entrapping the air layer in the nanostructured coating to reduce the contact between the surface and bacteria when exposed to the bacterial culture medium. The hydrothermal treatment was also reported as a pretreatment to improve the adhesion of other surface coatings (Dilshad et al, 2019;Xi et al, 2020).…”

Section: Hydrothermal Treatmentmentioning

confidence: 99%

Recent Progress in Surface Modification of Mg Alloys for Biodegradable Orthopedic Applications

et al. 2022

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The combination of light weight, strength, biodegradability, and biocompatibility of magnesium (Mg) alloys can soon break the paradigm for temporary orthopedic implants. As the fulfillment of Mg-based implants inside the physiological environment depends on the interaction at the tissue–implant interface, surface modification appears to be a more practical approach to control the rapid degradation rate. This article reviews recent progress on surface modification of Mg-based materials to tailor the degradation rate and biocompatibility for orthopedic applications. A critical analysis of the advantages and limitations of the various surface modification techniques employed are also included for easy reference of the readers.

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“…The most significant advantage is the Mg alloy is able to be adjusted to resorb after the bone-healing procedure. This could further decline the appeal to carry out a later surgery to delete it [5]. Mg alloys have been widely used in numerous usages like porous scaffolds for bone repair, bone fixation materials, and stents of cardiovascular [6].…”

Section: Introductionmentioning

confidence: 99%

Effect of ZnO nanoparticles addition to PEO coatings on AZ31B Mg alloy: antibacterial effect and corrosion behavior of coatings in Ringer’s physiological solution

Seyfi

Fattah‐alhosseini

Pajohi‐Alamoti

et al. 2021

Journal of Asian Ceramic Societies

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In this paper, the plasma electrolyte oxidation (PEO) technique was applied to modify the AZ31B Mg alloy surface. Effects of various concentrations of ZnO nanoparticles into an electrolyte with nanoparticles of hydroxyapatite (HAp) on the antibacterial and corrosion behavior of coatings were studied. Potentiodynamic polarization tests were done in Ringer's electrolyte to study the coatings corrosion behavior. Results of XRD indicated that the provided PEO films mostly have phases of HAp, MgO, and Mg 3 (PO 4 ) 2 and ZnO. The results indicated that increasing the concentration of ZnO nanoparticles raised the thickness, roughness, and wetting angle and also enhanced the coatings antibacterial activity. The inhibition percentage of bacterial growth for the specimen with the highest concentration of nanoparticles (4 g/L) after 6 h against E. coli and S. aureus was 23.5% and 45.5%, respectively. The concentration of nanoparticles had no major effect on the porosity size of the ceramic coating. Moreover, adding ZnO nanoparticles declined the corrosion current density and raised the corrosion potential with regard to the metal substrate. The formed coating in the solution containing 1 g/ L ZnO nanoparticles had the highest corrosion behavior among all of specimens that led to a 970 multiplication corrosion resistance of AZ31B Mg alloy.

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Corrosion Resistance and Biocompatibility Assessment of a Biodegradable Hydrothermal-Coated Mg–Zn–Ca Alloy: An in Vitro and in Vivo Study

Cited by 27 publications

References 47 publications

Zn–0.8Mg–0.2Sr (wt.%) Absorbable Screws—An In-Vivo Biocompatibility and Degradation Pilot Study on a Rabbit Model

Zn–0.8Mg–0.2Sr (wt.%) Absorbable Screws—An In-Vivo Biocompatibility and Degradation Pilot Study on a Rabbit Model

Recent Progress in Surface Modification of Mg Alloys for Biodegradable Orthopedic Applications

Effect of ZnO nanoparticles addition to PEO coatings on AZ31B Mg alloy: antibacterial effect and corrosion behavior of coatings in Ringer’s physiological solution

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