Purpose:
The aim of the present study is to determine the amount of titanium ions
released into the artificial salivary medium by modified glass ionomer cement (GIC) doped with 3% and 5%
(w/w) titanium dioxide nanoparticles (TiO2-NPs), and to evaluate their antibacterial properties.
Materials and methods:
120 cylindrical discs with a diameter of 4 mm and a height
of 6 mm were made with 3% and 5% w/w modified GIC containing TiO2 NPs, divided into two groups of 60,
and immersed in a chemically synthesized salivary medium. The samples were quantified over four-time
periods: 24 hours, two months, four months, and six months, using inductively coupled plasma mass
spectroscopy (ICP-MS), antibacterial properties were evaluated by means of colony forming count (CFU) method.
Results:
The amount of titanium ions released from the discs that received 3%(w/w)
TiO2 was highest in the first two months, with no significant release at successive intervals. Also,
the second group, which included 5% (w/w) TiO2, saw a considerable ion release at every interval,
with the second month seeing the maximum release. The levels in the 5% (w/w) group were consistently
higher when the two concentrations were compared at each of the four time points, indicating a
considerable increase in titanium release and antibacterial property with a concentration increase from
3% to 5%.
Conclusion:
3% and 5% (w/w) concentrations may be considered safe and exhibit
significant antimicrobial effect, titanium ions were discharged at higher rates in 5% (w/w) modified
GIC containing TiO2-NPs than in 3% (w/w) modified GIC containing TiO2-NPs.